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Träfflista för sökning "WFRF:(Jarvinen H) srt2:(2015-2019)"

Sökning: WFRF:(Jarvinen H) > (2015-2019)

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  • Overview of the JET results
  • 2015
  • Ingår i: Nuclear Fusion. - : IOP Publishing. - 0029-5515 .- 1741-4326. ; 55:10
  • Tidskriftsartikel (refereegranskat)
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  • Tabassum, R, et al. (författare)
  • Genetic architecture of human plasma lipidome and its link to cardiovascular disease
  • 2019
  • Ingår i: Nature communications. - : Springer Science and Business Media LLC. - 2041-1723. ; 10:1, s. 4329-
  • Tidskriftsartikel (refereegranskat)abstract
    • Understanding genetic architecture of plasma lipidome could provide better insights into lipid metabolism and its link to cardiovascular diseases (CVDs). Here, we perform genome-wide association analyses of 141 lipid species (n = 2,181 individuals), followed by phenome-wide scans with 25 CVD related phenotypes (n = 511,700 individuals). We identify 35 lipid-species-associated loci (P <5 ×10−8), 10 of which associate with CVD risk including five new loci-COL5A1, GLTPD2, SPTLC3, MBOAT7 and GALNT16 (false discovery rate<0.05). We identify loci for lipid species that are shown to predict CVD e.g., SPTLC3 for CER(d18:1/24:1). We show that lipoprotein lipase (LPL) may more efficiently hydrolyze medium length triacylglycerides (TAGs) than others. Polyunsaturated lipids have highest heritability and genetic correlations, suggesting considerable genetic regulation at fatty acids levels. We find low genetic correlations between traditional lipids and lipid species. Our results show that lipidomic profiles capture information beyond traditional lipids and identify genetic variants modifying lipid levels and risk of CVD.
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  • Joffrin, E., et al. (författare)
  • Impact of divertor geometry on H-mode confinement in the JET metallic wall
  • 2017
  • Ingår i: Nuclear Fusion. - : Institute of Physics Publishing (IOPP). - 0029-5515 .- 1741-4326. ; 57:8
  • Tidskriftsartikel (refereegranskat)abstract
    • Recent experiments with the ITER-like wall have demonstrated that changes in divertor strike point position are correlated with strong modification of the global energy confinement. The impact on energy confinement is observable both on the pedestal confinement and core normalised gradients. The corner configuration shows an increased core density gradient length and ion pressure indicating a better ion confinement. The study of neutral re-circulation indicates the neutral pressure in the main chamber varies inversely with the energy confinement and a correlation between the pedestal total pressure and the neutral pressure in the main chamber can be established. It does not appear that charge exchange losses nor momentum losses could explain this effect, but it may be that changes in edge electric potential are playing a role at the plasma edge. This study emphasizes the importance of the scrape-off layer (SOL) conditions on the pedestal and core confinement.
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  • Resultat 1-10 av 34

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