| 1. |
|
|
| 2. |
- Johansson, Annica, 1969, et al.
(författare)
-
Variants of CYP46A1 may interact with age and APOE to influence CSF Abeta42 levels in Alzheimer's disease.
- 2004
-
Ingår i: Human genetics. - : Springer Science and Business Media LLC. - 0340-6717 .- 1432-1203. ; 114:6, s. 581-7
-
Tidskriftsartikel (refereegranskat)abstract
- Recent studies have suggested that variants of CYP46A1, encoding cholesterol 24-hydroxylase (CYP46), confer risk for Alzheimer's disease (AD), a prospect substantiated by evidence of genetic association from several quantitative traits related to AD pathology, including cerebrospinal fluid (CSF) levels of the 42 amino-acid cleavage product of beta-amyloid (Abeta42) and the tau protein. In the present study, these claims have been explored by the genotyping of previously associated markers in CYP46A1 in three independent northern European case-control series encompassing 1323 individuals and including approximately 400 patients with measurements of CSF Abeta42 and phospho-tau protein levels. Tests of association in case-control models revealed limited evidence that CYP46A1 variants contributed to AD risk across these samples. However, models testing for potential effects upon CSF measures suggested a possible interaction of an intronic marker (rs754203) with age and APOE genotype. In stratified analyses, significant effects were evident that were restricted to elderly APOE epsilon4 carriers for both CSF Abeta42 ( P=0.0009) and phospho-tau ( P=0.046). Computational analyses indicate that the rs754203 marker probably does not impact the binding of regulatory factors, suggesting that other polymorphic sites underlie the observed associations. Our results provide an important independent replication of previous findings, supporting the existence of CYP46A1 sequence variants that contribute to variability in beta-amyloid metabolism.
|
|
| 3. |
|
|
| 4. |
- Olofsson, Henrik, 1972, et al.
(författare)
-
Odin water mapping in the Orion KL region
- 2003
-
Ingår i: Astronomy and Astrophysics. - : EDP Sciences. - 0004-6361 .- 1432-0746. ; 402, s. L47-L54
-
Tidskriftsartikel (refereegranskat)abstract
- New results from water mapping observations of the Orion KL region using the submm/mm wave satellite Odin (2.1\arcmin beam size at 557 GHz), are presented. The ortho-H2O \jkktrans{1}{1}{0}{1}{0}{1} ground state transition was observed in a 7arcminx 7arcmin rectangular grid with a spacing of 1\arcmin, while the same line of H218O was measured in two positions, Orion KL itself and 2\arcmin south of Orion KL. In the main water species, the KL molecular outflow is largely resolved from the ambient cloud and it is found to have an extension of 60\arcsec-110\arcsec. The H2O outflow profile exhibits a rather striking absorption-like asymmetry at the line centre. Self-absorption in the near (or ``blue'') part of the outflow (and possibly in foreground quiescent halo gas) is tentatively suggested to play a role here. We argue that the dominant part of the KL H218O outflow emission emanates from the compact (size ~ 15\arcsec) low-velocity flow and here estimate an H2O abundance of circa 10-5 compared to all H2 in the flow - an order of magnitude below earlier estimates of the H2O abundance in the shocked gas of the high-velocity flow. The narrow ambient cloud lines show weak velocity trends, both in the N-S and E-W directions. H218O is detected for the first time in the southern position at a level of ~ 0.15 K and we here estimate an H2O abundance of (1-8) x 10-8. Odin is a Swedish-led satellite project funded jointly by the Swedish National Space Board (SNSB), the Canadian Space Agency (CSA), the National Technology Agency of Finland (Tekes), and the Centre National d'Études Spatiales (CNES, France). The Swedish Space Corporation (SSC) was the industrial prime contractor and is also responsible for the satellite operation.
|
|
| 5. |
- Johansson, Annica, 1969, et al.
(författare)
-
Increased frequency of a new polymorphism in the cell division cycle 2 (cdc2) gene in patients with Alzheimer's disease and frontotemporal dementia.
- 2003
-
Ingår i: Neuroscience letters. - : Elsevier BV. - 0304-3940. ; 340:1, s. 69-73
-
Tidskriftsartikel (refereegranskat)abstract
- Recent studies show linkage between Alzheimer's disease (AD) and two loci on chromosome 10. The cell division cycle 2 (cdc2) gene is located close to one of the chromosome 10 markers, and is a candidate gene for AD since it is involved in the pathogenesis of AD. We sequenced coding exons and flanking intronic sequences and the promoter region on the cdc2 gene and found three new single nucleotide polymorphisms (SNPs). We analyzed 272 Caucasian AD cases, 160 controls and 70 cases with frontotemporal dementia (FTD) for these SNPs. Homozygosity for one of the SNPs (Ex6+7I/D) was more frequent in both AD and FTD cases than in controls. In the combined tauopathy (AD and FTD) group the odds ratio (OR) was 1.77 (95% CI 1.19-2.63) for the Ex6+7II genotype. Our findings suggest that the Ex6+7I allele is associated with tauopathies, both AD and FTD.
|
|
| 6. |
- Johansson, Sveneric, et al.
(författare)
-
New forbidden and fluorescence Fe III lines identified in HST spectra of eta Carinae
- 2001
-
Ingår i: Astronomy and Astrophysics. - 1432-0746. ; 361, s. 977-977
-
Tidskriftsartikel (refereegranskat)abstract
- We discuss the origin of eight emission lines in the spectra of gas blobs close to the central star of eta Carinae. The spectra have been obtained with the Goddard High Resolution Spectrograph (GHRS) and the Space Telescope Imaging Spectrograph (STIS) onboard the Hubble Space Telescope. Between 2400 and 2500 Å five narrow lines are identified as new forbidden lines of doubly ionized iron, [Fe III]. We present gA-value data for the corresponding transitions, which combine two different metastable configurations of Fe III. An anomalous intensity of the narrow Fe III line (UV 34) at 1914 Å is explained as fluorescence due to HLyalpha pumping. A level mixing of about 1% increases the f-value of the pumped excitation channel by more than two orders of magnitude, which makes the pumping efficient and the fluorescence significant. We introduce a new designation for fluorescence lines photoexcited by an accidental resonance, eg. < Fe III> in the case of doubly ionized iron. Based on observations with the NASA/ESA Hubble Space Telescope, and supported by grant numbers GO-6501 and GO-7302 from the Space Telescope Science Institute. The STScI is operated by the Association of Universities for Research in Astronomy, Inc., under NASA contract NAS5-26555.
|
|
| 7. |
- Johansson, Sveneric, et al.
(författare)
-
The FERRUM Project: New f-value Data for Fe II and Astrophysical Applications
- 2002
-
Ingår i: Physica Scripta. - : Institute of Physics Publishing (IOPP). - 0281-1847 .- 0031-8949 .- 1402-4896. ; T100, s. 71-80
-
Konferensbidrag (refereegranskat)abstract
- We present the FERRUM Project, an international collaboration aiming at a production and evaluation of oscillator strengths (transition probabilities) of selected spectral lines of singly ionized iron group elements, that are of astrophysical relevance. The results obtained include measurements and calculations of permitted and forbidden lines of Fe II. The data have been applied to both emission and absorption lines in astrophysical spectra. We make comparisons between experimental, theoretical and astrophysical f-values. We give a general review of the various measurements, and discuss the UV8 multiplet of Fe II around 1610 Šin detail.
|
|
| 8. |
- Simić, S. N., et al.
(författare)
-
Structural stability of hybrid systems1
- 2001
-
Ingår i: 2001 European Control Conference, ECC 2001. - : IEEE conference proceedings. - 9783952417362 ; , s. 3858-3863
-
Konferensbidrag (refereegranskat)abstract
- We study hybrid systems from a global geometric perspective as piecewise smooth dynamical systems. Based on an earlier work, we define the notion of the hybrifold as a single piece-wise smooth state space reflecting the dynamics of the original system. Structural stability for hybrid systems is introduced and analyzed in this framework. In particular, it is shown that a Zeno state is locally structurally stable and that a standard equilibrium on the boundary of a domain implies structural instability.
|
|
| 9. |
- Simic, Slobodan, et al.
(författare)
-
Towards a geometric theory of hybrid systems
- 2000
-
Ingår i: Lecture Notes in Computer Science. - : Springer-Verlag New York. - 0302-9743 .- 1611-3349. ; 1790, s. 421-436
-
Tidskriftsartikel (refereegranskat)
|
|
