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- Christiansson, Marie-Therese, et al.
(författare)
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En inter-organisatorisk förändringsanalys : utveckling av kund-/leverantörsprocessen
- 1997
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Konferensbidrag (refereegranskat)abstract
- Dagens sätt att göra affärer innebär ett ökat partnerskap och ett ökat datautbyte mellan organisationer i sökandet efter effektivitet och konkurrensfördelar. Affärsrelationer mellan leverantörer och kunder är beroende av att informationen flödar på ett strukturerat sätt mellan deras organisationer för att tillgodose respektive parts informationsbehov, dvs inter-organisatoriska informationssystem (IOIS). En metodutveckling pågår inom VINST-projektet där målet är att utveckla kunskap om och utforma en användbar metod som stöd vid verksamhetsutveckling av inter-organisatorisk karaktär. Denna rapport bygger på en metodprövande aktionsforskning vid en gemensam förändringsanalys som PartnerTech AB och en av deras kunder bedrivit med stöd av FA/SIMMetoden. Den metodtillämpning och metodutveckling som skett analyseras och diskuteras utifrån frågorna; hur en leverantör tillsammans med kunden kan utveckla den gemensamma kund-leverantörsprocessen och hur verksamhetsutvecklare kan använda FA/SIMM för att kartlägga och driva förbättring av inter-organisatoriska processer. Rapporten pekar bl a på behov av anpassade projektstrategier, arbetsformer och notation samt metodkomponenter för interaktionsanalys och uppföljning av åtgärder.
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- Johansson, Mikael
(författare)
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Scanning Tunnelling Microscopy and Spectroscopy of Adsorbates on Aluminium and Silicon
- 1997
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Doktorsavhandling (övrigt vetenskapligt/konstnärligt)abstract
- The main topic of this thesis is the investigation of atomic andmolecular adsorbates on single crystal surfaces of silicon and aluminiumusing the techniques of scanning tunnelling microscopy (STM) andspectroscopy (STS). The emphasis has been to use atomic-resolutionspectroscopy and imaging to determine the relationship between thesurfaces' geometric and electronic structures. The STM results have beenprofitably compared with synchrotron-based valence band and core levelphotoelectron spectroscopy (PES) data to provide a more complete picturethan any single technique could provide. On Si(001) a peak seen in valence band PES at Li coverages up to 0.4 MLwas explained by STM images showing a local perturbation of theSi(001)-2x1 reconstruction by the Li atoms. STM also showed that Liadsorption on p-type substrates created localised electron traps whichinduced negative differential resistance in tunnel spectra. The formation of 3D islands of metallic MoSi2 was shown to be a generalfeature of annealing 0.1 - 10 ML Mo films on Si(001) and Si(111) at 800 C.STM and STS showing the growth of the silicide islands at the expense ofatomic-scale features formed at lower temperatures was correlated withPES data showing the changes in the Si bonding on the surface. STS of Rb on Al(111) revealed that the (Root(3)xRoot(3))R30 overlayer formedat room temperature confined electrons to a 2D quantum well state. STM ofthe growing layer supported existing models for the (Root(3)xRoot(3))R30reconstruction and a complex structure formed at lower coverages, as well asdemonstrating the existence of kinetic barriers to atomic motion on thesurface. STM of C60 on Al(111) showed details of the growth of a (2Root(3)x2Root(3))R30ordered overlayer at room temperature. Spectroscopy of an annealedsurface proved that inequivalent molecules in its (6x6) unit cell havedifferent molecular energy levels and bonding to the substrate.
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- Johansson, Mikael, et al.
(författare)
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Tumor blood flow and the cytotoxic effects of estramustine and its constituents in a rat glioma model
- 1997
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Ingår i: Neurosurgery. - : Oxford University Press. - 0148-396X .- 1524-4040. ; 41:1, s. 237-244
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Tidskriftsartikel (refereegranskat)abstract
- OBJECTIVE: Estramustine (EaM) is a conjugate of nor-nitrogen mustard (NNM) and 17 beta-estradiol (E2) that has cytotoxic and radiosensitizing effects on experimental malignant glioma. Its mechanism of action is only partly understood. To further investigate the mechanism in vivo, the effects on tumor blood flow (TBF) and tumor growth were analyzed.METHODS: TBF was measured by radioactive microspheres, and tumor growth was measured by weight. Apoptosis was evaluated by in situ end labeling and gel electrophoresis. The effects of the constituents NNM and E2 were also evaluated.RESULTS: EaM increased TBF to 153.8 ml/100 g/min after 3 days and to 153.9 ml/100 g/min after 10 days of treatment, compared with 94.0 ml/100 g/min in untreated controls. Cerebral blood flow did not change after EaM treatment. NNM increased TBF but also showed a tendency to increase cerebral blood flow. E2 increased TBF, whereas cerebral blood flow was unchanged. EaM resulted in a rapid reduction in tumor weight from 230 mg in untreated animals to 146 mg after 3 days of treatment. EaM induced an early transient fragmentation of deoxyribonucleic acid in glioma but not in the normal brain. Neither NNM nor E2 affected tumor weight.CONCLUSION: EaM increases TBF in the BT4C rat glioma model with a concomitant rapid antitumoral effect. The increase in TBF could partially be induced by an estrogen-like action of EaM, but the rapid cytotoxic effect of the drug is obviously attributed to the intact EaM compound. This cytotoxic effect might be attributable to the induction of programmed cell death.
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- Möller, Mikael, et al.
(författare)
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New analytical model of inelastic local flange buckling
- 1997
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Ingår i: Journal of constructional steel research. - 0143-974X .- 1873-5983. ; 43:1-3, s. 43-63
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Tidskriftsartikel (refereegranskat)abstract
- This paper deals with analytical modelling of inelastic local flange buckling of compressed I-beam flanges. A short discussion of the relevance of different constitutive models for the inelastic material behaviour is carried out. It is claimed that what is known as the `plastic buckling paradox' is not at all a paradox but a result of improper use of plasticity theory. An analytical model for the inelastic local buckling of an I-beam flange is proposed. The model considers the buckling process as being composed of two pans. The first is associated with inelastic torsional buckling of a compressed flange and the second part corresponds to a yield line plate buckling configuration which includes the effect of stress redistribution due to large deformations. The transition between these phases is left out in the model. The model is capable of predicting approximately the force-deformation relation of a locally buckling stocky flange for different stress-strain relations. The model is evaluated against experiments and the agreement is found quite reasonable.
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