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- Kim, Hyeong Seok, et al.
(författare)
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Development, validation, and comparison of a nomogram based on radiologic findings for predicting malignancy in intraductal papillary mucinous neoplasms of the pancreas : An international multicenter study
- 2021
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Ingår i: Journal of hepato-biliary-pancreatic sciences. - : Wiley-Blackwell. - 1868-6974 .- 1868-6982.
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Tidskriftsartikel (refereegranskat)abstract
- BACKGROUND: Although we previously proposed a nomogram to predict malignancy in intraductal papillary mucinous neoplasms (IPMN) and validated it in an external cohort, its application is challenging without data on tumor markers. Moreover, existing nomograms have not been compared. This study aimed to develop a nomogram based on radiologic findings and to compare its performance with previously proposed American and Korean/Japanese nomograms.METHODS: We recruited 3708 patients who underwent surgical resection at 31 tertiary institutions in eight countries, and patients with main pancreatic duct >10 mm were excluded. To construct the nomogram, 2606 patients were randomly allocated 1:1 into training and internal validation sets, and area under the receiver operating characteristics curve (AUC) was calculated using 10-fold cross validation by exhaustive search. This nomogram was then validated and compared to the American and Korean/Japanese nomograms using 1102 patients.RESULTS: Among the 2606 patients, 90 had main-duct type, 900 had branch-duct type, and 1616 had mixed-type IPMN. Pathologic results revealed 1628 low-grade dysplasia, 476 high-grade dysplasia, and 502 invasive carcinoma. Location, cyst size, duct dilatation, and mural nodule were selected to construct the nomogram. AUC of this nomogram was higher than the American nomogram (0.691 vs 0.664, P = .014) and comparable with the Korean/Japanese nomogram (0.659 vs 0.653, P = .255).CONCLUSIONS: A novel nomogram based on radiologic findings of IPMN is competitive for predicting risk of malignancy. This nomogram would be clinically helpful in circumstances where tumor markers are not available. The nomogram is freely available at http://statgen.snu.ac.kr/software/nomogramIPMN.
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| 2. |
- Kim, Jihye, et al.
(författare)
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Association of coffee, tea, and caffeine consumption with intraocular pressure and interaction with genetic risk : findings from the UK Biobank
- 2020
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Ingår i: Investigative Ophthalmology and Visual Science. - : Association for Research in Vision and Ophthalmology. - 0146-0404 .- 1552-5783. ; 61:7
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Tidskriftsartikel (övrigt vetenskapligt/konstnärligt)abstract
- Purpose : Coffee and tea are commonly consumed caffeinated beverages that may affect ocular health. Hence, it is of interest whether caffeine intake affects intraocular pressure (IOP). Some studies reported that coffee and caffeine consumption is associated with higher IOP. However, evidence from large-scale general population studies is limited. Methods : We included 121,755 UK Biobank participants (aged 39-73y) who had dietary data and cornea-compensated IOP measurements in 2006-2010. In a subset (n=78,017), data were available from up to five web-based 24-hour-recall food frequency questionnaires (2009-2012); we derived participants’ total caffeine consumption based on caffeine content and frequency of caffeine-containing food intake. Using multivariable linear regression, we assessed the cross-sectional relationships between coffee or tea intake (cups/day) and IOP (mmHg) as primary analyses and the associations between total caffeine intake (80 mg/day) and IOP (mmHg) as secondary analyses. Analyses were adjusted for age, sex, ethnicity, smoking, alcohol intake, physical activity, deprivation, body mass index, blood pressure, and diabetes (and total energy intake in the subset). To explore gene-diet interactions, we examined interactions between coffee, tea, caffeine intake and an IOP polygenic risk score (PRS) combining effects of 111 genetic variants associated with IOP identified by genome-wide association studies. Results : Mean (SD) IOP was 16.0 (3.8) mmHg. Higher coffee, tea, and total caffeine intakes were associated with lower IOP (-0.049, -0.045 and -0.039 mmHg, respectively; P ≤ 0.001). When evaluating PRS-diet interactions, we found positive and significant interactions with tea and caffeine intake (both P-interactions < 0.05), where higher tea and caffeine intake was associated with lower IOP among individuals with IOP PRS in the lower 75th percentile, while among individuals with high IOP PRS (top 25th percentile), higher intakes were associated with modestly higher IOP. Conclusions : We found evidence for very weak associations between higher coffee, tea and caffeine intake and lower IOP. However, our finding on gene-diet interactions suggest that genetic predisposition to higher IOP may influence the association between caffeinated beverage consumption and IOP.
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| 3. |
- Kim, Jihye, et al.
(författare)
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Intraocular pressure, glaucoma and dietary caffeine consumption : a gene-diet interaction study from the UK Biobank
- 2021
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Ingår i: Ophthalmology. - : Elsevier. - 0161-6420 .- 1549-4713. ; 128:6, s. 866-876
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Tidskriftsartikel (refereegranskat)abstract
- Purpose: We examined the association of habitual caffeine intake with intraocular pressure (IOP) and glaucoma and whether genetic predisposition to higher IOP modified these associations. We also assessed whether genetic predisposition to higher coffee consumption was related to IOP.Design: Cross-sectional study in the UK Biobank.Participants: We included 121 374 participants (baseline ages, 39-73 years) with data on coffee and tea intake (collected 2006-2010) and corneal-compensated IOP measurements in 2009. In a subset of 77 906 participants with up to 5 web-based 24-hour-recall food frequency questionnaires (2009-2012), we evaluated total caffeine intake. We also assessed the same relationships with glaucoma (9286 cases and 189 763 controls).Methods: We evaluated multivariable-adjusted associations with IOP using linear regression and with glaucoma using logistic regression. For both outcomes, we examined gene-diet interactions using a polygenic risk score (PRS) that combined the effects of 111 genetic variants associated with IOP. We also performed Mendelian randomization using 8 genetic variants associated with coffee intake to assess potential causal effects of coffee consumption on IOP.Main Outcome Measures: Intraocular pressure and glaucoma.Results: Mendelian randomization analysis did not support a causal effect of coffee drinking on IOP (P > 0.1). Greater caffeine intake was associated weakly with lower IOP: the highest (>= 232 mg/day) versus lowest (<87 mg/day) caffeine consumption was associated with a 0.10-mmHg lower IOP (P-trend = 0.01). However, the IOP PRS modified this association: among those in the highest IOP PRS quartile, consuming > 480 mg/day versus < 80 mg/day was associated with a 0.35-mmHg higher IOP (P-interaction = 0.01). The relationship between caffeine intake and glaucoma was null (P >= 0.1). However, the IOP PRS also modified this relationship: compared with those in the lowest IOP PRS quartile consuming no caffeine, those in the highest IOP PRS quartile consuming >= 321 mg/day showed a 3.90-fold higher glaucoma prevalence (P-interaction = 0.0003).Conclusions: Habitual caffeine consumption was associated weakly with lower IOP, and the association between caffeine consumption and glaucoma was null. However, among participants with the strongest genetic predisposition to elevated IOP, greater caffeine consumption was associated with higher IOP and higher glaucoma prevalence.
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