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Diffusion of ionic ...
Diffusion of ionic and non-ionic contrast agents in articular cartilage with increased cross-linking : contribution of steric and electrostatic effects
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- Kulmala, Katariina (författare)
- Department of Applied Physics, University of Eastern Finland, Kuopio, Finland
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- Karjalainen, Hannu (författare)
- Institute of Biomedicine, University of Eastern Finland, Kuopio, Finland
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- Kokkonen, Harri (författare)
- Department of Applied Physics, University of Eastern Finland, Kuopio, Finland
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- Tiitu, Virpi (författare)
- Institute of Biomedicine, University of Eastern Finland, Kuopio, Finland
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- Kovanen, Vuokko (författare)
- Department of Health Sciences, University of Jyväskylä, Jyväskylä, Finland
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- Lammi, Mikko, 1961- (författare)
- Institute of Biomedicine, University of Eastern Finland, Kuopio, Finland,Chondrogenic and Osteogenic Differentiation Group
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- Jurvelin, Jukka (författare)
- Department of Applied Physics, University of Eastern Finland, Kuopio, Finland
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- Korhonen, Rami (författare)
- Department of Applied Physics, University of Eastern Finland, Kuopio, Finland
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- Töyräs, Juha (författare)
- Department of Applied Physics, University of Eastern Finland, Kuopio, Finland; Department of Clinical Neurophysiology, Kuopio University Hospital, Kuopio, Finland
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(creator_code:org_t)
- Elsevier, 2013
- 2013
- Engelska.
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Ingår i: Medical Engineering and Physics. - : Elsevier. - 1350-4533 .- 1873-4030. ; 35:10, s. 1415-20
- Relaterad länk:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- OBJECTIVE: To investigate the effect of threose-induced collagen cross-linking on diffusion of ionic and non-ionic contrast agents in articular cartilage.DESIGN: Osteochondral plugs (Ø=6mm) were prepared from bovine patellae and divided into two groups according to the contrast agent to be used in contrast enhanced computed tomography (CECT) imaging: (I) anionic ioxaglate and (II) non-ionic iodixanol. The groups I and II contained 7 and 6 sample pairs, respectively. One of the paired samples served as a reference while the other was treated with threose to induce collagen cross-linking. The equilibrium partitioning of the contrast agents was imaged after 24h of immersion. Fixed charge density (FCD), water content, contents of proteoglycans, total collagen, hydroxylysyl pyridinoline (HP), lysyl pyridinoline (LP) and pentosidine (Pent) cross-links were determined as a reference.RESULTS: The equilibrium partitioning of ioxaglate (group I) was significantly (p=0.018) lower (-23.4%) in threose-treated than control samples while the equilibrium partitioning of iodixanol (group II) was unaffected by the threose-treatment. FCD in the middle and deep zones of the cartilage (p<0.05) and contents of Pent and LP (p=0.001) increased significantly due to the treatment. However, the proteoglycan concentration was not systematically altered after the treatment. Water content was significantly (-3.5%, p=0.007) lower after the treatment.CONCLUSIONS: Since non-ionic iodixanol showed no changes in partition after cross-linking, in contrast to anionic ioxaglate, we conclude that the cross-linking induced changes in charge distribution have greater effect on diffusion compared to the cross-linking induced changes in steric hindrance.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Cell- och molekylärbiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Cell and Molecular Biology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Ortopedi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Orthopaedics (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Radiologi och bildbehandling (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Radiology, Nuclear Medicine and Medical Imaging (hsv//eng)
Nyckelord
- articular cartilage
- aging
- contrast agent
- computed tomography
- ortopedi
- Orthopaedics
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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Kulmala, Katarii ...
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Karjalainen, Han ...
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Kokkonen, Harri
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Tiitu, Virpi
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Kovanen, Vuokko
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Lammi, Mikko, 19 ...
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Jurvelin, Jukka
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Korhonen, Rami
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Töyräs, Juha
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