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- Ingelson, M, et al.
(författare)
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Tau immunoreactivity detected in human plasma, but no obvious increase in dementia
- 1999
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Ingår i: Dementia and geriatric cognitive disorders. - : S. Karger AG. - 1420-8008 .- 1421-9824. ; 10:6, s. 442-445
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Tidskriftsartikel (refereegranskat)abstract
- <i>Tau</i> proteins are central to the neuropathology of Alzheimer’s disease and <i>tau</i> levels in cerebrospinal fluid are elevated in affected individuals. In this study, we investigated the presence of <i>tau</i> in plasma from subjects with Alzheimer’s disease (n = 16), frontotemporal dementia (n = 10), vascular dementia (n = 16) and from healthy controls (n = 15). By using an ELISA with monoclonal <i>tau</i> antibodies, <i>tau</i> immunoreactivity was detected in approximately 20% of the subjects. However, no difference between the disease and control groups was seen. After gel filtration of <i>tau</i> immunopositive plasma, the peak reactivity was found in the 160-kD fraction, indicating the source to be <i>tau</i>-like molecules of high-molecular-weight or polymers of low-molecular-weight <i>tau</i> isoforms. We conclude that measurements of <i>tau</i> in plasma cannot be utilized diagnostically for Alzheimer’s disease or for the other dementias investigated.
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