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Träfflista för sökning "WFRF:(Larsson Susanna C.) srt2:(2004)"

Sökning: WFRF:(Larsson Susanna C.) > (2004)

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1.
  • Larsson, Susanna C, et al. (författare)
  • Dietary long-chain n-3 fatty acids for the prevention of cancer : a review of potential mechanisms
  • 2004
  • Ingår i: American Journal of Clinical Nutrition. - : Elsevier BV. - 0002-9165 .- 1938-3207. ; 79:6, s. 935-45
  • Tidskriftsartikel (refereegranskat)abstract
    • Increasing evidence from animal and in vitro studies indicates that n-3 fatty acids, especially the long-chain polyunsaturated fatty acids eicosapentaenoic acid and docosahexaenoic acid, present in fatty fish and fish oils inhibit carcinogenesis. The epidemiologic data on the association between fish consumption, as a surrogate marker for n-3 fatty acid intake, and cancer risk are, however, somewhat less consistent. This review highlights current knowledge of the potential mechanisms of the anticarcinogenic actions of n-3 fatty acids. Moreover, a possible explanation of why some epidemiologic studies failed to find an association between n-3 fatty acid intake and cancer risk is provided. Several molecular mechanisms whereby n-3 fatty acids may modify the carcinogenic process have been proposed. These include suppression of arachidonic acid-derived eicosanoid biosynthesis; influences on transcription factor activity, gene expression, and signal transduction pathways; alteration of estrogen metabolism; increased or decreased production of free radicals and reactive oxygen species; and mechanisms involving insulin sensitivity and membrane fluidity. Further studies are needed to evaluate and verify these mechanisms in humans to gain more understanding of the effects of n-3 fatty acid intake on cancer risk.
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2.
  • Larsson, Susanna C., et al. (författare)
  • Fruit and vegetable consumption in relation to ovarian cancer incidence : the Swedish Mammography Cohort
  • 2004
  • Ingår i: British Journal of Cancer. - : Springer Science and Business Media LLC. - 0007-0920 .- 1532-1827. ; 90:11, s. 2167-70
  • Tidskriftsartikel (refereegranskat)abstract
    • We prospectively examined the incidence of epithelial ovarian cancer and its subtypes in relation to baseline fruit and vegetable consumption in the Swedish Mammography Cohort, a population-based cohort study of 61 084 women aged 38-76 years in 1987-1990. During an average follow-up of 13.5 years, 266 incident cases of invasive epithelial ovarian cancer were diagnosed. After adjustment for potential confounders, we observed a statistically significant inverse association between consumption of vegetables and ovarian cancer risk (P-value for trend=0.01); the multivariate rate ratio (RR) for the comparison of three or more servings of vegetables per day with one or fewer servings per day was 0.61 (95% confidence interval (CI), 0.38-0.97). For fruit consumption a modest, not statistically significant, positive association was found (P-value for trend=0.07); the multivariate RR for the highest compared with the lowest category of consumption being 1.37 (95% CI, 0.90-2.06). The associations with fruit and vegetable consumption did not vary by subtype of ovarian cancer. These findings suggest that high consumption of vegetables, but not of fruits, may reduce the risk of ovarian cancer.
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4.
  • Larsson, Susanna C, et al. (författare)
  • Wine consumption and epithelial ovarian cancer
  • 2004
  • Ingår i: Cancer Epidemiology, Biomarkers and Prevention. - 1055-9965 .- 1538-7755. ; 13:11 Pt 1, s. 1823; author reply 1823-4
  • Tidskriftsartikel (refereegranskat)
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  • Resultat 1-4 av 4
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Wolk, Alicja (4)
Larsson, Susanna C. (4)
Holmberg, Lars (1)
Bergkvist, Leif (1)
Kumlin, Maria (1)
Ingelman-Sundberg, M ... (1)
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Karolinska Institutet (4)
Uppsala universitet (3)
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