| 41. |
- Lin, Na, et al.
(författare)
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Differences in Two-Photon and One-Photon Absorption Profiles Induced by Vibronic Coupling : The Case of Dioxaborine Heterocyclic Dye
- 2011
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Ingår i: ChemPhysChem. - : Wiley. - 1439-4235 .- 1439-7641. ; 12:17, s. 3392-3403
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Tidskriftsartikel (refereegranskat)abstract
- A theoretical study of a dioxaborine heterocyclic compound in solution provides a case study for an analysis of the effects induced by the so-called HerzbergTeller (HT) vibronic coupling on the one- (OPA) and two-photon absorption (TPA) spectra. For TPA, the HT vibronic coupling induces differences in the shapes of the absorption band. The study highlights the importance of vibronic coupling as a potentially important mechanism in absorption spectroscopy, able to explain differences in the OPA/TPA spectra.
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| 42. |
- McClune, Brian L., et al.
(författare)
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Allotransplantation for Patients Age >= 40 Years with Non-Hodgkin Lymphoma : Encouraging Progression-Free Survival
- 2014
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Ingår i: Biology of blood and marrow transplantation. - : Elsevier BV. - 1083-8791 .- 1523-6536. ; 20:7, s. 960-968
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Tidskriftsartikel (refereegranskat)abstract
- Non-Hodgkin lymphoma (NHL) disproportionately affects older patients, who do not often undergo allogeneic hematopoietic cell transplantation (HCT). We analyzed Center for International Blood and Marrow Transplant Research data on 1248 patients age >= 40 years receiving reduced-intensity conditioning (RIC) or nonmyeloablative (NMA) conditioning HCT for aggressive (n = 668) or indolent (n = 580) NHL Aggressive lymphoma was more frequent in the oldest cohort 49% for age 40 to 54 versus 57% for age 55 to 64 versus 67% for age >= 65; P = .0008). Fewer patients aged >= 65 had previous autografting (26% versus 24% versus 9%; P = .002). Rates of relapse, acute and chronic GVHD, and nonrelapse mortality (NRM) at 1 year post-HCT were similar in the 3 age cohorts (22% [95% confidence interval (CI), 19% to 26%] for age 40 to 54, 27% [95% CI, 23% to 31%] for age 55 to 64, and 34% [95% CI, 24% to 44%] for age >= 65. Progression-free survival (PFS) and overall survival (OS) at 3 years was slightly lower in the older cohorts (OS: 54% [95% CI, 50% to 58%] for age 40 to 54; 40% [95% CI, 36% to 44%] for age 55 to 64, and 39% [95% CI, 28% to 50%] for age >= 65; P < .0001). Multivariate analysis revealed no significant effect of age on the incidence of acute or chronic GVHD or relapse. Age >= 55 years, Karnofsky Performance Status <80, and HLA mismatch adversely affected NRM, PFS, and OS. Disease status at HCT, but not histological subtype, was associated with worse NRM, relapse, PFS, and OS. Even for patients age >= 55 years, OS still approached 40% at 3 years, suggesting that HCT affects long-term remission and remains underused in qualified older patients with NHL.
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| 43. |
- Qiu, Feng, et al.
(författare)
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A new IQ detection method for LLRF
- 2012
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Ingår i: Nuclear Instruments & Methods in Physics Research. Section A: Accelerators, Spectrometers, Detectors, and Associated Equipment. - : Elsevier BV. - 0167-5087 .- 0168-9002. ; 675, s. 139-143
-
Tidskriftsartikel (refereegranskat)abstract
- Digital LLRF technology has been widely used in new generation particle accelerators. IF quadrature sampling is a common method for amplitude and phase detection. Many strategies, which obey the same rule of f(sample) = (M/N)f(IF) (M/N is a rational number), have been proposed to reduce the effects of spectrum aliasing. However, we found that M/N does not need to be a rational number according to Shannon's theorem. Therefore, we propose a new IQ detection method in this paper. This method is based on a special IIR filter which is derived from an RLC circuit. The unique characteristic of the method is that the value of f(IF) is independent of the value of, f(sample). We have set up an experimental platform to verify our method. A 122.88 MHz sampling clock is used to sample a 3 MHz IF signal. The DOS and PI control techniques are used to realize the closed-loop control. Results show that the stability of the system is within +/- 0.05% (peak to peak) for the amplitude, and with +/- 0.03 degrees (peak to peak) for the phase in 5 h. (C) 2012 Elsevier B.V. All rights reserved.
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| 44. |
- Segerie, Audrey, et al.
(författare)
-
Effects of the basis set and of the exchange-correlation functional on the Inelastic Electron Tunneling signatures of 1,4-benzenedithiol
- 2014
-
Ingår i: Spectrochimica Acta Part A - Molecular and Biomolecular Spectroscopy. - : Elsevier BV. - 1386-1425 .- 1873-3557. ; 119, s. 34-41
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Tidskriftsartikel (refereegranskat)abstract
- The effects of the atomic basis set and of the exchange-correlation (XC). functional on the Inelastic Electron Tunneling (LET) spectra have been investigated by considering the prototypical 1,4-benzenedithiol molecule. These studies have been completed by tackling the reliability of the same methods for predicting the IR absorption spectrum of the same molecule. The main conclusions are (i) the B3LYP XC functional is suitable to predict the relative vibrational frequencies, (ii) provided a scaling factor is used, the root mean square error on the vibrational frequencies goes down to 18 cm(-1), (iii) triple-zeta basis sets and in particular the cc-pVTZ basis set is a good compromise between accuracy and computational needs, (iv) basis set effects on the IET intensities are larger than those of the XC functional, and (v) the cc-pVTZ, cc-pVQZ, and aug-cc-pVDZ basis sets provide consistent IET intensities.
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| 45. |
- Segerie, Audrey, et al.
(författare)
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Theoretical Insight into the Inelastic Electron Tunneling Spectra of an Anil Derivative
- 2013
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Ingår i: Journal of Physical Chemistry A. - : American Chemical Society (ACS). - 1089-5639 .- 1520-5215. ; 117:48, s. 12783-12795
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Tidskriftsartikel (refereegranskat)abstract
- First-principles simulations have been employed to simulate the inelastic electron tunneling (JET) spectra of the enol and keto forms of an anil molecular switch and to analyze them with respect to the character of the vibrational normal modes. When the molecules are sandwiched between Au plates, the dominant JET signatures appear at very similar voltages for both forms, but their intensities are clearly different, which makes JET an efficient technique to probe the molecular state of the switch. The JET-active modes are also similar for both anil forms and consist of in-plane molecular motions, CC and ring stretching, and C-H bending motions. Moreover, the JET activity of the vibrational modes specific to the enol and keto forms, i.e., those involving bending motions of the C-O-H and C-N-H groups, respectively, demonstrates that JET spectroscopy is an efficient technique to distinguish unambiguously between the two states of the keto/enol switch.
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| 46. |
- Shao, Linus Ruijin, 1964, et al.
(författare)
-
Direct effects of metformin in the endometrium: a hypothetical mechanism for the treatment of women with PCOS and endometrial carcinoma
- 2014
-
Ingår i: Journal of Experimental & Clinical Cancer Research. - : Springer Science and Business Media LLC. - 1756-9966. ; 33:41
-
Forskningsöversikt (refereegranskat)abstract
- Abstract Although a number of in vitro studies have demonstrated the antiproliferative, anti-invasive, and antimetastatic effects of metformin in multiple cancer cell types, its cellular and molecular mechanisms of anti-cancer action in the endometrium of women with polycystic ovary syndrome (PCOS) have not yet been fully elucidated. Organic cation transporters (OCTs) and multidrug and toxin extrusion proteins (MATEs) are known to be involved in metformin uptake and excretion in cells. In this article, we discuss the novel therapeutic possibilities for early-stage endometrial carcinoma (EC) in women with PCOS focusing on metformin, which might have a direct effect in the endometrium through the OCTs and MATEs. We then review the molecular mechanism(s) of the action of metformin in the endometrium and highlight possible mechanistic insights into the inhibition of cell proliferation and tumor growth and, ultimately, the reversal of early-stage EC into normal endometria in women with PCOS.
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| 47. |
- Shi, Yantao, et al.
(författare)
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A green route and rational design for ZnO-based high-efficiency photovoltaics
- 2014
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Ingår i: Nanoscale. - : Royal Society of Chemistry (RSC). - 2040-3364 .- 2040-3372. ; 6:10, s. 5093-5098
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Tidskriftsartikel (refereegranskat)abstract
- In this work, at room-temperature and without any organic surfactants we reported two green and facile approaches for rapid synthesis of ZnO nanorods (NRs) and nanosheet-based ZnO hierarchical structures (NSHSs). Based on their structural advantages, the quasi-solid ZnO-DSCs achieved a record photoelectric conversion efficiency (PCE) of 6.83%.
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| 48. |
- Shi, Yantao, et al.
(författare)
-
Solid-State Synthesis of ZnO Nanostructures for Quasi-Solid Dye-Sensitized Solar Cells with High Efficiencies up to 6.46%
- 2013
-
Ingår i: Advanced Materials. - : Wiley. - 0935-9648 .- 1521-4095. ; 25:32, s. 4413-4419
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Tidskriftsartikel (refereegranskat)abstract
- Solid-state synthesis of ZnO nanostructured building blocks is presented in this work for the fabrication of high efficiency quasi-solid dye-sensitized solar cells (DSSCs). The sponge-like photoanode has high optical density and better connections. Baking the photoanode at low temperature, photoconversion efficiencies of up to 6.46% are yielded by the quasi-solid DSSCs. Furthermore, we demonstrate better stability of our ZnO quasi-solid DSSCs.
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| 49. |
- Sun, Yi-lin, et al.
(författare)
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Detangling the impacts of age, residential locations and household lifecycle in car usage and ownership in the Osaka metropolitan area, Japan
- 2014
-
Ingår i: Zhejiang University. Journal. Science A: Applied Physics & Engineering. - 1673-565X. ; 15:7, s. 517-528
-
Tidskriftsartikel (refereegranskat)abstract
- Using large cross-sectional datasets that were collected in the Osaka metropolitan area (OMA), Japan, this study systematically analyzes the structural changes in car ownership and usage in the OMA from 1970 to 2000. A simultaneous equations model system is developed for individuals that considers age, household lifecycle stage, built environment of the household location, car ownership levels, proportion of car trips on a given day, and total car travel duration. The estimation results show that private car ownership and car usage for the residents in OMA have expanded over time. Each residential area, each lifecycle stage, and each age group has their own unique characteristics of car ownership and car usage. The results further indicate that this expansion is largely due to changes in their structural relationships, while the changes in demographic factors play a relatively small and contradictory role.
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| 50. |
- Wang, Lei, et al.
(författare)
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Linking DNA methylation to the onset of human tubal ectopic pregnancy.
- 2013
-
Ingår i: American journal of translational research. - 1943-8141. ; 5:2, s. 116-25
-
Tidskriftsartikel (refereegranskat)abstract
- Ectopic pregnancy is a common reproductive disorder of unknown etiology and is a leading cause of maternal and fetal mortality. Because of the asymptomatic nature of early tubal ectopic pregnancy and the lack of specific biomarkers for early diagnosis, a better understanding of the complex cellular and molecular interactions that contribute to tubal ectopic pregnancy is required. DNA methylation is the most studied epigenetic process in various tissues and cells, and the goal of this article is to provide a brief review of recent work describing the potential mechanisms of DNA methylation and the biological function of such methylation in normal intrauterine pregnancy. Further, novel findings from our laboratory highlight the possible role of DNA methylation in human Fallopian tube dysfunction and suggest a possible correlation between methylation of estrogen receptor α in women and the occurrence of tubal ectopic pregnancies.
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