| 51. |
- Kapilashrami, Mukes, et al.
(författare)
-
Understanding the magnetic interaction between intrinsic defects and impurity ions in room-temperature ferromagnetic Mg1-xFexO thin films
- 2016
-
Ingår i: Journal of Physics. - : IOP Publishing. - 0953-8984 .- 1361-648X. ; 28:15
-
Tidskriftsartikel (refereegranskat)abstract
- Understanding the nature and characteristics of the intrinsic defects and impurities in the dielectric barrier separating the ferromagnetic electrodes in a magnetic tunneling junction is of great importance for understanding the often observed 'barrier-breakdown' therein. In this connection, we present herein systematic experimental (SQUID and synchrotron-radiation-based x-ray absorption spectroscopy) and computational studies on the electronic and magnetic properties of Mg1-xFexO thin films. Our studies reveal: (i) defect aggregates comprised of basic and trimer units (Fe impurity coupled to 1 or 2 Mg vacancies) and (ii) existence of two competing magnetic orders, defect- and dopant-induced, with spin densities aligning anti-parallel if the trimer is present in the oxide matrix. These findings open up new avenues for designing tunneling barriers with high endurance and tunneling effect upon tuning the concentration/distribution of the two magnetic orders.
|
|
| 52. |
- Kristan, Matej, et al.
(författare)
-
The Visual Object Tracking VOT2014 Challenge Results
- 2015
-
Ingår i: COMPUTER VISION - ECCV 2014 WORKSHOPS, PT II. - Cham : Springer. - 9783319161808 - 9783319161815 ; , s. 191-217
-
Konferensbidrag (refereegranskat)abstract
- The Visual Object Tracking challenge 2014, VOT2014, aims at comparing short-term single-object visual trackers that do not apply pre-learned models of object appearance. Results of 38 trackers are presented. The number of tested trackers makes VOT 2014 the largest benchmark on short-term tracking to date. For each participating tracker, a short description is provided in the appendix. Features of the VOT2014 challenge that go beyond its VOT2013 predecessor are introduced: (i) a new VOT2014 dataset with full annotation of targets by rotated bounding boxes and per-frame attribute, (ii) extensions of the VOT2013 evaluation methodology, (iii) a new unit for tracking speed assessment less dependent on the hardware and (iv) the VOT2014 evaluation toolkit that significantly speeds up execution of experiments. The dataset, the evaluation kit as well as the results are publicly available at the challenge website (http://votchallenge.net).
|
|
| 53. |
- Li, Tianfeng, et al.
(författare)
-
Bruton’s tyrosine kinase potentiates ALK signaling and serves as a potential therapeutic target of neuroblastoma
- 2018
-
Ingår i: Oncogene. - : Springer Science and Business Media LLC. - 0950-9232 .- 1476-5594. ; 37:47, s. 6180-6194
-
Tidskriftsartikel (refereegranskat)abstract
- Aberrant activation of anaplastic lymphoma kinase (ALK) can cause sporadic and familial neuroblastoma. Using a proteomics approach, we identified Bruton’s tyrosine kinase (BTK) as a novel ALK interaction partner, and the physical interaction was confirmed by co-immunoprecipitation. BTK is expressed in neuroblastoma cell lines and tumor tissues. Its high expression correlates with poor relapse-free survival probability of neuroblastoma patients. Mechanistically, we demonstrated that BTK potentiates ALK-mediated signaling in neuroblastoma, and increases ALK stability by reducing ALK ubiquitination. Both ALKWT and ALKF1174L can induce BTK phosphorylation and higher capacity of ALKF1174L is observed. Furthermore, the BTK inhibitor ibrutinib can effectively inhibit the growth of neuroblastoma xenograft in nude mice, and the combination of ibrutinib and the ALK inhibitor crizotinib further enhances the inhibition. Our study provides strong rationale for clinical trial of ALK-positive neuroblastoma using ibrutinib or the combination of ibrutinib and ALK inhibitors.
|
|
| 54. |
|
|
| 55. |
- Lin, Li, et al.
(författare)
-
An adhesive bonding approach by hydrogen silsesquioxane for silicon carbide-based LED applications
- 2019
-
Ingår i: Materials Science in Semiconductor Processing. - : ELSEVIER SCI LTD. - 1369-8001 .- 1873-4081. ; 91
-
Tidskriftsartikel (refereegranskat)abstract
- We report an adhesive bonding approach using hydrogen silsesquioxane (HSQ) for silicon carbide (SiC) samples. A hybrid light-emitting diode (LED) was successfully fabricated through bonding a near-ultraviolet (NUV) LED grown on a commercial 4H-SiC substrate to a free-standing boron-nitrogen co-doped fluorescent-SiC epi-layer. The bonding quality and the electrical performance of the hybrid LED device were characterized. Neither voids nor defects were observed which indicates a good bonding quality of the proposed HSQ approach. A strong warm white emission was successfully obtained from the hybrid LED through an electric current injection of 30 mA.
|
|
| 56. |
- Lin, Yi, et al.
(författare)
-
Dietary animal and plant protein intakes and their associations with obesity and cardio-metabolic indicators in European adolescents : The HELENA cross-sectional study
- 2015
-
Ingår i: Nutrition Journal. - : Springer Science and Business Media LLC. - 1475-2891. ; 14:10
-
Tidskriftsartikel (refereegranskat)abstract
- Background: Previous studies suggest that dietary protein might play a beneficial role in combating obesity and its related chronic diseases. Total, animal and plant protein intakes and their associations with anthropometry and serum biomarkers in European adolescents using one standardised methodology across European countries are not well documented. Objectives: To evaluate total, animal and plant protein intakes in European adolescents stratified by gender and age, and to investigate their associations with cardio-metabolic indicators (anthropometry and biomarkers). Methods: The current analysis included 1804 randomly selected adolescents participating in the HELENA study (conducted in 2006-2007) aged 12.5-17.5 y (47% males) who completed two non-consecutive computerised 24-h dietary recalls. Associations between animal and plant protein intakes, and anthropometry and serum biomarkers were examined with General linear Model multivariate analysis. Results: Average total protein intake exceeded the recommendations of World Health Organization and European Food Safety Authority. Mean total protein intake was 96 g/d (59% derived from animal protein). Total, animal and plant protein intakes (g/d) were significantly lower in females than in males and total and plant protein intakes were lower in younger participants (12.5-14.9 y). Protein intake was significantly lower in underweight subjects and higher in obese ones; the direction of the relationship was reversed after adjustments for body weight (g/(kg.d)). The inverse association of plant protein intakes was stronger with BMI z-score and body fat percentage (BF%) compared to animal protein intakes. Additionally, BMI and BF% were positively associated with energy percentage of animal protein. Conclusions: This sample of European adolescents appeared to have adequate total protein intake. Our findings suggest that plant protein intakes may play a role in preventing obesity among European adolescents. Further longitudinal studies are needed to investigate the potential beneficial effects observed in this study in the prevention of obesity and related chronic diseases.
|
|
| 57. |
- Lin, Yen-Ku, et al.
(författare)
-
A versatile low-resistance ohmic contact process with ohmic recess and low-temperature annealing for GaN HEMTs
- 2018
-
Ingår i: Semiconductor Science and Technology. - : IOP Publishing. - 1361-6641 .- 0268-1242. ; 33:9
-
Tidskriftsartikel (refereegranskat)abstract
- Deeply recessed ohmic contacts for GaN-based high electron mobility transistors (HEMTs) are demonstrated. It is shown that low-resistance ohmic contacts can be achieved with recessing beyond the AlGaN Schottky barrier where the ohmic contacts are formed on the sidewall of the recess. This makes the process versatile and relatively insensitive to the exact recess depth. The ohmic contact is based on a gold-free metallization scheme consisting of a Ta/Al/Ta metal stack requiring a low-temperature annealing. Important parameters for this type of ohmic contact process include the metal coverage, slope of the etched sidewall, bottom Ta-layer thickness, as well as annealing temperature and duration. The optimized contact resistance is as low as 0.24 Omega mm after annealing at 575 degrees C. Moreover, this sidewall contact approach was successfully implemented on different epitaxial heterostructures with different AlGaN barrier thickness as well as with and without AlN exclusion layer. All the samples exhibited excellent contact resistances in a wide range of recess depths. The Ta-based, sidewall ohmic contact process is a promising method for forming an ohmic contact on a wide range of GaN HEMT epitaxial designs.
|
|
| 58. |
- Lin, Zhong-Yi, et al.
(författare)
-
Investigating the physical properties of outbursts on comet 67P/Churyumov-Gerasimenko
- 2017
-
Ingår i: Monthly notices of the Royal Astronomical Society. - : OXFORD UNIV PRESS. - 0035-8711 .- 1365-2966. ; 469, s. S731-S740
-
Tidskriftsartikel (refereegranskat)abstract
- Cometary outbursts on several comets have been observed both by ground-based telescopes and by in situ instruments on spacecraft. However, the mechanism behind these phenomena and their physical properties are still unclear. The optical, spectrocopic and infrared remote imaging system (OSIRIS) onboard the Rosetta spacecraft provided first-hand information on the outbursts from comet 67P/Churyumov-Gerasimenko during its perihelion passage in 2015. The physical properties of the outbursts can be investigated by examining the time series of these high-resolution images. An analysis is made of the wide- and narrow-angle images obtained during the monitoring of the outburst sequences, which occurred between July and September in 2015. A ring-masking technique is used to calculate the excess brightness of the outbursts. The ejected mass and expansion velocity of the outbursts is estimated from differences in images made with the same filter (orange filter). The calculated excess brightness from these outburst plumes ranges from a few per cent to 28 per cent. In some major outbursts, the brightness contribution from the outburst plume can be one or two times higher than that of the typical coma jet activities. The strongest event was the perihelion outburst detected just a few hours before perihelion. The mass ejection rate during a generic outburst could reach a few per cent of the steady-state value of the dust coma. Transient events are detected by studying the brightness slope of the outburst plume with continuous streams of outflowing gas and dust triggered by driving mechanisms, as yet not understood, which remain active for several minutes to less than a few hours.
|
|
| 59. |
- Lindstrom, Linda S., et al.
(författare)
-
Intratumor Heterogeneity of the Estrogen Receptor and the Long-term Risk of Fatal Breast Cancer
- 2018
-
Ingår i: Journal of the National Cancer Institute. - : OXFORD UNIV PRESS INC. - 0027-8874 .- 1460-2105. ; 110:7, s. 726-733
-
Tidskriftsartikel (refereegranskat)abstract
- Background: Breast cancer patients with estrogen receptor (ER)-positive disease have a continuous long-term risk for fatal breast cancer, but the biological factors influencing this risk are unknown. We aimed to determine whether high intratumor heterogeneity of ER predicts an increased long-term risk (25 years) of fatal breast cancer. Methods: The STO-3 trial enrolled 1780 postmenopausal lymph node-negative breast cancer patients randomly assigned to receive adjuvant tamoxifen vs not. The fraction of cancer cells for each ER intensity level was scored by breast cancer pathologists, and intratumor heterogeneity of ER was calculated using Raos quadratic entropy and categorized into high and low heterogeneity using a predefined cutoff at the second tertile (67%). Long-term breast cancer-specific survival analyses by intra-tumor heterogeneity of ER were performed using Kaplan-Meier and multivariable Cox proportional hazard modeling adjusting for patient and tumor characteristics. Results: A statistically significant difference in long-term survival by high vs low intratumor heterogeneity of ER was seen for all ER-positive patients (P amp;lt; .001) and for patients with luminal A subtype tumors (P = .01). In multivariable analyses, patients with high intratumor heterogeneity of ER had a twofold increased long-term risk as compared with patients with low intratumor heterogeneity (ER-positive: hazard ratio (HR] = 1.98, 95% confidence interval (CI] = 1.31 to 3.00; luminal A subtype tumors: HR = 2.43, 95% CI -1.18 to 4.99). Conclusions: Patients with high intratumor heterogeneity of ER had an increased long-term risk of fatal breast cancer. Interestingly, a similar long-term risk increase was seen in patients with luminal A subtype tumors. Our findings suggest that intratumor heterogeneity of ER is an independent long-term prognosticator with potential to change clinical management, especially for patients with luminal A tumors.
|
|
| 60. |
- Liu, Juzhe, et al.
(författare)
-
Ultrathin amorphous cobalt-vanadium hydr(oxy)oxide catalysts for the oxygen evolution reaction
- 2018
-
Ingår i: Energy & Environmental Science. - : Royal Society of Chemistry. - 1754-5692 .- 1754-5706. ; 11:7, s. 1736-1741
-
Tidskriftsartikel (refereegranskat)abstract
- Cost efficient and long-term stable catalysts are in great demand for the oxygen evolution reaction (OER), a key process involved in water splitting cells and metal-air batteries. Here, we demonstrate that the ultrathin amorphous cobalt-vanadium hydr(oxy)oxide we synthesized is a highly promising electrocatalytic material for the OER with a low overpotential of 0.250 V (even lower down to 0.215 V when supported on Au foam) at 10 mA cm(-2) and a long stable operation time (170 h) in alkaline media. In combination with in situ X-ray absorption spectral characterization and first-principles simulations, we reveal that the ultrathin, amorphous and alloyed structural characteristics have enabled its facile transformation to the desirable active phase, leading to a dramatically enhanced catalytic activity. Our finding highlights the remarkable advantages of the two-dimensional amorphous material and sheds new light on the design of high-performance electrocatalysts.
|
|
