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- Halfvarson, Jonas, 1970-, et al.
(författare)
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Inflammatory bowel disease in a Swedish twin cohort : a long-term follow-up of concordance and clinical characteristics
- 2003
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Ingår i: Gastroenterology. - 0016-5085 .- 1528-0012. ; 124:7, s. 1767-1773
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Tidskriftsartikel (refereegranskat)abstract
- Background & Aims:In 1988, we reported the first twin study in inflammatory bowel disease. The aim of the current study was to follow up these twins regarding new cases of inflammatory bowel disease and Crohn’s disease characteristics using the Vienna classification.Methods:The official Swedish population register and the cause of death register were used to search for the twins. All living patients were interviewed.Results:Three monozygotic twins earlier classified as healthy had been diagnosed with inflammatory bowel disease (ulcerative colitis, n = 2; Crohn’s disease, n = 1). Retrospectively, all 3 were symptomatic at the original survey. This changed the pair concordance in monozygotic twins from 6.3% to 18.8% in ulcerative colitis and from 44.4% to 50.0% in Crohn’s disease. A high degree of concordance regarding age at diagnosis, disease location at diagnosis and during the course, and disease behavior was found in concordant monozygotic twin pairs with Crohn’s disease. Seven of 9 pairs were identical in 3 or more of these disease characteristics compared with an expected number of 1.5 (P = 0.000076).Conclusions:This study confirms that the genetic influence is stronger in Crohn’s disease than in ulcerative colitis. A remarkable phenotype similarity within concordant pairs with Crohn’s disease was found using the Vienna classification.
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- Halfvarson, Jonas, 1970-, et al.
(författare)
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Inflammatory bowel disease in a Swedish twin cohort : a long-term follow-up of concordance and clinical characteristics
- 2003
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Ingår i: Gastroenterology. - : Elsevier BV. - 0016-5085 .- 1528-0012. ; 124:7, s. 1767-1773
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Tidskriftsartikel (refereegranskat)abstract
- BACKGROUND & AIMS: In 1988, we reported the first twin study in inflammatory bowel disease. The aim of the current study was to follow up these twins regarding new cases of inflammatory bowel disease and Crohn's disease characteristics using the Vienna classification.METHODS: The official Swedish population register and the cause of death register were used to search for the twins. All living patients were interviewed.RESULTS: Three monozygotic twins earlier classified as healthy had been diagnosed with inflammatory bowel disease (ulcerative colitis, n = 2; Crohn's disease, n = 1). Retrospectively, all 3 were symptomatic at the original survey. This changed the pair concordance in monozygotic twins from 6.3% to 18.8% in ulcerative colitis and from 44.4% to 50.0% in Crohn's disease. A high degree of concordance regarding age at diagnosis, disease location at diagnosis and during the course, and disease behavior was found in concordant monozygotic twin pairs with Crohn's disease. Seven of 9 pairs were identical in 3 or more of these disease characteristics compared with an expected number of 1.5 (P = 0.000076).CONCLUSIONS: This study confirms that the genetic influence is stronger in Crohn's disease than in ulcerative colitis. A remarkable phenotype similarity within concordant pairs with Crohn's disease was found using the Vienna classification.
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- Hultkrantz, Lars, et al.
(författare)
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Intelligent Economic Speed Adaptation
- 2003
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Ingår i: 10th International Conference on Travel Behaviour Research. - Lucerne, Switzerland.
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Konferensbidrag (övrigt vetenskapligt/konstnärligt)
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- Hultkrantz, Lars, et al.
(författare)
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Intelligent economic speed adaptation
- 2003
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Ingår i: 10th International Conference on Travel Behaviour Research (IATBR). ; , s. 1-20
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Konferensbidrag (övrigt vetenskapligt/konstnärligt)abstract
- Internalisation of external costs of transport has hitherto been focused on distance-based charges. While this may affect driven distance, it has no influence on driving behaviour. We demonstrate in this economic field experiment that it today is possible to observe drivers actual behaviour with GPS technology and thus possible to refine the economic incentives. To ensure participation, we give drivers a monthly bonus, which is reduced according to the speed behaviour. We make the experiment with two different bonus levels and two different price levels. Our pricing scheme significantly reduces the proportion speed violations of the participants and we conclude that this is a possible way to improve car drivers speed behaviour.
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- Johansen, Finn Tore, et al.
(författare)
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The cost 249 speechdat multilingual reference recogniser
- 2000
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Konferensbidrag (refereegranskat)abstract
- The COST 249 SpeechDat reference recogniser is a fully automatic, language-independent training procedure for building a phonetic recogniser. It relies on the HTK toolkit and a SpeechDat(II) compatible database. The recogniser is designed to serve as a reference system in multilingual recognition research. This paper documents version 0.93 of the reference recogniser and presents results on smallvocabulary recognition for seven languages.
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