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- Baekkeskov, S, et al.
(författare)
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Antibodies to a 64,000 Mr human islet cell antigen precede the clinical onset of insulin-dependent diabetes
- 1987
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Ingår i: Journal of Clinical Investigation. - 0021-9738. ; 79:3, s. 34-926
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Tidskriftsartikel (refereegranskat)abstract
- Antibodies in sera from newly diagnosed insulin-dependent diabetes mellitus (IDDM) patients are directed to a human islet cell protein of relative molecular mass (Mr) 64,000. Since IDDM seems to develop after a prodromal period of beta-cell autoimmunity, this study has examined whether 64,000 Mr antibodies could be detected in 14 individuals who subsequently developed IDDM and five first degree relatives who have indications of altered beta-cell function. Sera were screened by immunoprecipitation on total detergent lysates of human islets and positive sera retested on membrane protein preparations. Antibodies to the 64,000 Mr membrane protein were consistently detected in 11/14 IDDM patients, and in all 5 first degree relatives. 10 IDDM patients were already positive in the first samples, obtained 4-91 mo before the clinical onset of IDDM, whereas 1 patient progressed to a high 64,000 Mr immunoreactivity, at a time where a commencement of a decline in beta-cell function was detected. 64,000 Mr antibodies were detected before islet cell cytoplasmic antibodies (ICCA) in two patients. In the control groups of 21 healthy individuals, 36 patients with diseases of the thyroid and 5 SLE patients, the 64,000 Mr antibodies were detected in only one individual, who was a healthy sibling to an IDDM patient. These results suggest that antibodies against the Mr 64,000 human islet protein are an early marker of beta-cell autoimmunity and may be useful to predict a later development of IDDM.
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| 2. |
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| 3. |
- Ong, J.H., et al.
(författare)
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A hidden line algorithm for finite element preprocessor
- 1988
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Ingår i: Proceedings of ICONCG 88 International Conference on Computer Graphics 1988 : 15-16 September 1988 at Hyatt Regency Hotel, Singapore. - : School of Electrical. ; , s. 499-510
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Konferensbidrag (refereegranskat)
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| 4. |
- Tam, S.C., et al.
(författare)
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Computer simulation of temperature fields in mechanised plasma-arc welding
- 1989
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Ingår i: Journal of Mechanical Working Technology. - : Elsevier BV. - 0378-3804. ; 19:1, s. 23-33
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Tidskriftsartikel (refereegranskat)abstract
- The process of the mechanised plasma-arc butt-welding of thin-gauge mild-steel sheets has been studied, both theoretically and experimentally. The transient temperature distribution has been computed using an analytical model due to Rosenthal. The results have then been compared with those generated by finite-element analysis using the commercial package PAFEC. The two sets of results were found to be in reasonably good agreement; moreover, the theoretical values were found to correlate fairly well with the results of experiments performed on a Messer Griesheim Uniwig G-200P plasma-arc welding machine.The extent of the heat-affected zone (HAZ) in the butt-welded specimens has been computed by analysing the temperature history at points lying transverse to the weldment: the theoretical values match fairly closely with those obtained from the welding experiments.The efficiency of the plasma-arc welding process has been estimated to be around 32% to 35%.
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