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Amount and Intensit...
Amount and Intensity of Leisure-Time Physical Activity and Lower Cancer Risk
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- Matthews, Charles E. (author)
- NCI, Div Canc Epidemiol & Genet, Metab Epidemiol Branch, Bethesda, MD 20892 USA
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- Moore, Steven C. (author)
- NCI, Div Canc Epidemiol & Genet, Metab Epidemiol Branch, Bethesda, MD 20892 USA
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- Arem, Hannah (author)
- George Washington Univ, Sch Publ Hlth, Dept Epidemiol, Washington, DC USA
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- Cook, Michael B. (author)
- NCI, Div Canc Epidemiol & Genet, Metab Epidemiol Branch, Bethesda, MD 20892 USA
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- Trabert, Britton (author)
- NCI, Div Canc Epidemiol & Genet, Metab Epidemiol Branch, Bethesda, MD 20892 USA
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- Håkansson, Niclas (author)
- Karolinska Institutet
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- Larsson, Susanna C. (author)
- Karolinska Institutet,Uppsala universitet,Ortopedi,Karolinska Inst, Inst Environm Med, Unit Cardiovasc & Nutr Epidemiol, Stockholm, Sweden
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- Wolk, Alicja (author)
- Karolinska Institutet,Uppsala universitet,Ortopedi,Karolinska Inst, Inst Environm Med, Unit Cardiovasc & Nutr Epidemiol, Stockholm, Sweden
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- Gapstur, Susan M. (author)
- Amer Canc Soc, Behav & Epidemiol Res, Atlanta, GA 30329 USA
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- Lynch, Brigid M. (author)
- Canc Council Victoria, Canc Epidemiol Div, Melbourne, Vic, Australia;Univ Melbourne, Ctr Epidemiol & Biostat, Sch Populat & Global Hlth, Melbourne, Vic, Australia;Baker Heart & Diabet Inst, Phys Act Lab, Melbourne, Vic, Australia
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- Milne, Roger L. (author)
- Canc Council Victoria, Canc Epidemiol Div, Melbourne, Vic, Australia;Univ Melbourne, Ctr Epidemiol & Biostat, Sch Populat & Global Hlth, Melbourne, Vic, Australia;Monash Univ, Sch Clin Sci, Precis Med, Monash Hlth, Melbourne, Vic, Australia
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- Freedman, Neal D. (author)
- NCI, Div Canc Epidemiol & Genet, Metab Epidemiol Branch, Bethesda, MD 20892 USA
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- Huang, Wen-Yi (author)
- NCI, Div Canc Epidemiol & Genet, Metab Epidemiol Branch, Bethesda, MD 20892 USA
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- de Gonzalez, Amy Berrington (author)
- NCI, Div Canc Epidemiol & Genet, Radiat Epidemiol Branch, Bethesda, MD 20892 USA
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- Kitahara, Cari M. (author)
- NCI, Div Canc Epidemiol & Genet, Radiat Epidemiol Branch, Bethesda, MD 20892 USA
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- Linet, Martha S. (author)
- Karolinska Institutet
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- Shiroma, Eric J. (author)
- NIA, Lab Epidemiol & Populat Sci, Baltimore, MD 21224 USA
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- Sandin, Sven (author)
- Karolinska Inst, Dept Med Epidemiol & Biostat, Stockholm, Sweden;Icahn Sch Med Mt Sinai, Dept Psychiat, New York, NY 10029 USA;Seaver Autism Ctr Res & Treatment Mt Sinai, New York, NY USA
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- Patel, Alpa, V (author)
- Amer Canc Soc, Behav & Epidemiol Res, Atlanta, GA 30329 USA
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- Lee, I-Min (author)
- Brigham & Womens Hosp, 75 Francis St, Boston, MA 02115 USA;Harvard Med Sch, Harvard TH Chan Sch Publ Hlth, Boston, MA 02115 USA
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(creator_code:org_t)
- AMER SOC CLINICAL ONCOLOGY, 2020
- 2020
- English.
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In: Journal of Clinical Oncology. - : AMER SOC CLINICAL ONCOLOGY. - 0732-183X .- 1527-7755. ; 38:7, s. 686-697
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https://uu.diva-port... (primary) (Raw object)
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Abstract
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- PURPOSE: To determine whether recommended amounts of leisure-time physical activity (ie, 7.5-15 metabolic equivalent task [MET] hours/week) are associated with lower cancer risk, describe the shape of the dose-response relationship, and explore associations with moderate- and vigorous-intensity physical activity.METHODS: Data from 9 prospective cohorts with self-reported leisure-time physical activity and follow-up for cancer incidence were pooled. Multivariable Cox regression was used to estimate adjusted hazard ratios (HRs) and 95% CIs of the relationships between physical activity with incidence of 15 types of cancer. Dose-response relationships were modeled with restricted cubic spline functions that compared 7.5, 15.0, 22.5, and 30.0 MET hours/week to no leisure-time physical activity, and statistically significant associations were determined using tests for trend (P < .05) and 95% CIs (< 1.0).RESULTS: A total of 755,459 participants (median age, 62 years [range, 32-91 years]; 53% female) were followed for 10.1 years, and 50,620 incident cancers accrued. Engagement in recommended amounts of activity (7.5-15 MET hours/week) was associated with a statistically significant lower risk of 7 of the 15 cancer types studied, including colon (8%-14% lower risk in men), breast (6%-10% lower risk), endometrial (10%-18% lower risk), kidney (11%-17% lower risk), myeloma (14%-19% lower risk), liver (18%-27% lower risk), and non-Hodgkin lymphoma (11%-18% lower risk in women). The dose response was linear in shape for half of the associations and nonlinear for the others. Results for moderate- and vigorous-intensity leisure-time physical activity were mixed. Adjustment for body mass index eliminated the association with endometrial cancer but had limited effect on other cancer types.CONCLUSION: Health care providers, fitness professionals, and public health practitioners should encourage adults to adopt and maintain physical activity at recommended levels to lower risks of multiple cancers.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
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- art (subject category)
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- By the author/editor
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Matthews, Charle ...
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Moore, Steven C.
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Arem, Hannah
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Cook, Michael B.
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Trabert, Britton
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Håkansson, Nicla ...
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show more...
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Larsson, Susanna ...
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Wolk, Alicja
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Gapstur, Susan M ...
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Lynch, Brigid M.
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Milne, Roger L.
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Freedman, Neal D ...
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Huang, Wen-Yi
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de Gonzalez, Amy ...
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Kitahara, Cari M ...
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Linet, Martha S.
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Shiroma, Eric J.
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Sandin, Sven
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Patel, Alpa, V
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Lee, I-Min
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Cancer and Oncol ...
- Articles in the publication
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Journal of Clini ...
- By the university
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Uppsala University
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Karolinska Institutet