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Inflammation in ren...
Inflammation in renal transplantation
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- Abedini, Sadollah (författare)
- Renal Medicine Research Group
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- Holme, Ingar (författare)
- Renal Medicine Research Group
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- März, Winfried (författare)
- Renal Medicine Research Group
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- Weihrauch, Gisela (författare)
- Renal Medicine Research Group
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- Fellström, Bengt, 1947- (författare)
- Uppsala universitet,Institutionen för medicinska vetenskaper,Renal Medicine Research Group
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- Jardine, Alan (författare)
- Renal Medicine Research Group
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- Cole, Edward (författare)
- Renal Medicine Research Group
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- Maes, Bart (författare)
- Renal Medicine Research Group
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- Neumayer, Hans-Hellmut (författare)
- Renal Medicine Research Group
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- Grönhagen-Riska, Carola (författare)
- Renal Medicine Research Group
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- Ambühl, Patrice (författare)
- Renal Medicine Research Group
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- Holdaas, Halvard (författare)
- Renal Medicine Research Group
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(creator_code:org_t)
- 2009
- 2009
- Engelska.
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Ingår i: Journal of the American Society of Nephrology. - 1046-6673 .- 1533-3450. ; 4:7, s. 1246-1254
- Relaterad länk:
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https://urn.kb.se/re...
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https://doi.org/10.2...
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Abstract
Ämnesord
Stäng
- BACKGROUND AND OBJECTIVES: Renal transplant recipients experience premature cardiovascular disease and death. The association of inflammation, all-cause mortality, and cardiovascular events in renal transplant recipients has not been examined in a large prospective controlled trial. DESIGN, SETTING, PARTICIPANTS, & MEASUREMENTS: ALERT was a randomized, double-blind, placebo-controlled study of the effect of fluvastatin on cardiovascular and renal outcomes in 2102 renal transplant recipients. Patients initially randomized to fluvastatin or placebo in the 5- to 6-yr trial were offered open-label fluvastatin in a 2-yr extension to the original study. The association between inflammation markers, high-sensitivity C-reactive protein (hsCRP), and IL-6 on cardiovascular events and all-cause mortality was investigated. RESULTS: The baseline IL-6 value was 2.9 +/- 1.9 pg/ml (n = 1751) and that of hsCRP was 3.8 +/- 6.7 mg/L (n = 1910). After adjustment for baseline values for established risk factors, the hazard ratios for a major cardiac event and all-cause mortality for IL-6 were 1.08 [95% confidence interval (CI), 1.01 to 1.15, P = 0.018] and 1.11 (95% CI, 1.05 to 1.18, P < 0.001), respectively. The adjusted hazard ratio for hsCRP for a cardiovascular event was 1.10 (95% CI, 1.01 to 1.20, P = 0.027) and for all-cause mortality was 1.15 (95% CI, 1.06 to 1.1.25, P = 0.049). CONCLUSIONS: The inflammation markers IL-6 and hsCRP are independently associated with major cardiovascular events and all-cause mortality in renal transplant recipients.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Urologi och njurmedicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Urology and Nephrology (hsv//eng)
Nyckelord
- Inflammation
- renal transplantation
- Kidney diseases
- Njursjukdomar
- Medicin
- Medicine
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- art (ämneskategori)
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Abedini, Sadolla ...
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Holme, Ingar
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März, Winfried
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Weihrauch, Gisel ...
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Fellström, Bengt ...
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Jardine, Alan
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Cole, Edward
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Maes, Bart
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Neumayer, Hans-H ...
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Grönhagen-Riska, ...
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Ambühl, Patrice
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Holdaas, Halvard
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