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Träfflista för sökning "WFRF:(Magnus P) srt2:(1980-1984)"

Sökning: WFRF:(Magnus P) > (1980-1984)

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1.
  • Bjursten, Lars Magnus, et al. (författare)
  • The kinetics of leucocyte migration into rabbit knee joints elicited by preformed immune complexes with different in vitro characteristics
  • 1983
  • Ingår i: Immunology. - 0019-2805. ; 49:2, s. 205-213
  • Tidskriftsartikel (refereegranskat)abstract
    • Immune complexes were formed in vitro with antibodies obtained from rabbits immunized with bovine serum albumin in Freund's complete (FCA) or incomplete (FIA) adjuvant. The antibodies were mixed with different amounts of antigen. Immune complexes formed at maximum precipitation proportions were efficient in complement activation, whereas immune complexes formed at antigen excess had weak complement-activating properties. When injected into rabbit knee joints, the immune complexes formed at maximum precipitation proportions with FCA or FIA antibodies caused a moderate leucocyte migration into the joints with maximum cell counts 6-8 hr after injection. Injection into the joints of immune complexes formed with FCA antibodies at antigen excess induced a pronounced leucocyte migration with maximum numbers 18 hr after injection. Immunofluorescent studies indicated that these immune complexes became associated with the leucocyte membrane, whereas immune complexes formed at maximum precipitation proportions were found in the leucocyte granulae, indicating that only the complement-activating immune complexes were efficiently eliminated.
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3.
  • Thomsen, P, et al. (författare)
  • Inhibitory effect of honey bee venom on immune complex mediated leukocyte migration into rabbit knee-joints
  • 1984
  • Ingår i: Agents and Actions. - 0065-4299. ; 14:5-6, s. 662-666
  • Tidskriftsartikel (refereegranskat)abstract
    • The anti-inflammatory effect of purified honey bee venom (HBV) was studied using a recently described animal model in which preformed immune complexes were injected into rabbit knee-joints. As little as a single injection of 1.2 micrograms HBV/kg body weight subcutaneously significantly reduced the immune complex induced joint inflammation as measured by reduction in leukocyte counts in the joint fluid. This decrease was obvious 3 and 6 but not 9 hours after induction of the inflammation. There was no significant effect on leukocyte random migration, chemotactic responsiveness or phagocytosis, indicating that HBV did not interfere with normal phagocyte motility and ingestion. The modifying effects by HBV on the inflammatory response to immune complexes in vivo is most likely due to interference with other components of the inflammatory response.
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