↓ Direkt till sidans innehåll
↓ Direkt till sidans sekundära innehåll (sidomenyn)

Träfflista för sökning "WFRF:(Mahteme Haile) srt2:(2005-2009);srt2:(2007)"

Sökning: WFRF:(Mahteme Haile) > (2005-2009) > (2007)

Resultat 1-2 av 2

Sortera/gruppera träfflistan

Sortering: Träffar per sida:

Numrering	Referens	Omslagsbild	Hitta
1.	Ceelen, Wim P., et al. (författare) Pharmacodynamic aspects of intraperitoneal cytotoxic therapy 2007 Ingår i: Cancer treatment and research. - 0927-3042. ; 134, s. 195-214 Tidskriftsartikel (refereegranskat)abstract The rationale for ip administration as an adjunct to surgery is firmly based on theoretical and pharmacokinetic grounds. The superiority of combined ip and intravenous chemotherapy over intravenous chemotherapy alone has been established in randomized trials in stage IIIc ovarian cancer patients. Intraoperative ip cytotoxic therapy results in a definite pharmacological advantage, since high peritoneal concentrations are achieved with limited systemic absorption. At present, however, it is not clearly established to what extent this PK advantage will result in enhanced anticancer activity and, ultimately, in a survival benefit. Preclinical models show that direct penetration into tumour tissue is limited to a few millimeters. Furthermore, the limited exposure time of intraoperative chemoperfusion could limit cytotoxic activity despite high local concentrations. Among the cytotoxic agents currently used, the pharmacodynamic aspects of the platinum compounds are the best studied both with and without associated hyperthermia. Newer agents such as the taxanes and the camptothecins appear promising for ip chemoperfusion during or immediately after surgery. Pharmacodynamic aspects of HIPEC needing further preclinical study-including mathematical modeling - are the establishment of tumour tissue penetration of the newer agents and its relation to hyperthermia, the definition of the relative contribution of direct penetration versus vascular supply by absorbed drug, and the efficacy of combined ip and intravenous regimens. Ultimately, however, randomised trials of ip chemotherapy with surgery will have to provide the evidence base to further build upon.
2.	Esquivel, J., et al. (författare) Cytoreductive surgery and hyperthermic intraperitoneal chemotherapy in the management of peritoneal surface malignancies of colonic origin : A consensus statement 2007 Ingår i: Annals of Surgical Oncology. - : Springer Science and Business Media LLC. - 1068-9265 .- 1534-4681. ; 14:1, s. 128-133 Tidskriftsartikel (refereegranskat)

Skapa referenser, mejla, bekava och länka

Länka till träfflistan

Resultat 1-2 av 2

Avgränsa träffmängd

Typ av publikation: tidskriftsartikel (2)

Typ av innehåll: refereegranskat (2)

Författare/redaktör: Mahteme, Haile (2); Li, B. (1); Elias, D. (1); Lange, J (1); Påhlman, Lars (1); Glehen, O (1); visa fler...; Barone, R (1); Kecmanovic, D (1); Foster, J (1); Daniel, S (1); Saha, S (1); Riley, L (1); Quinones, M (1); Martin, R (1); Philippe, G. (1); Villar, J (1); Morris, D. (1); Goodman, M. (1); Mann, G. (1); Garofalo, A. (1); Hartmann, J. (1); Bartlett, D (1); Stewart, J (1); Piso, P. (1); Gonzalez-Moreno, S. (1); Deraco, M. (1); Moran, B. (1); Petrelli, N (1); Ceelen, Wim P. (1); Alexander, R. (1); Kane, J. (1); Chu, F (1); Kuhn, J. (1); Hanna, N (1); Chang, C. K. (1); Esquivel, J (1); Sticca, R (1); Sugarbaker, P (1); Levine, E (1); Yan, T D (1); Baratti, D (1); Barrios, P (1); Bieligk, S (1); Bretcha-Boix, P (1); Chu, Q (1); Debree, E (1); Dominguez-Parra, L (1); Flynn, R (1); Gilly, F N (1); Gomez-Portilla, A (1); visa färre...

Lärosäte: Uppsala universitet (2)

Språk: Engelska (2)

År: 2007 (2)Ta bort avgränsningen

Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.

Copyright © LIBRIS - Nationella bibliotekssystem
LIBRIS.kb.se

pil uppåt

Stäng

Kopiera och spara länken för att återkomma till aktuell vy