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Träfflista för sökning "WFRF:(Mahteme Haile) srt2:(2010-2014);srt2:(2010)"

Sökning: WFRF:(Mahteme Haile) > (2010-2014) > (2010)

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1.
  • Näslund Andréasson, Sara, et al. (författare)
  • Is Platinum Present in Blood and Urine from Treatment Givers during Hyperthermic Intraperitoneal Chemotherapy?
  • 2010
  • Ingår i: Journal of oncology. - : Hindawi Limited. - 1687-8469 .- 1687-8450. ; 2010, s. 649719-
  • Tidskriftsartikel (refereegranskat)abstract
    • Background. In selected patients with peritoneal carcinomatosis (PC) originating from colorectal cancer (CRC) the high dosage of oxaliplatin (460 mg/m(2)) is recommended for hyperthermic intraperitoneal chemotherapy (HIPEC), which may be a health risk to those administering the drug. The aim of this study was to determine the risk of platinum (Pt) exposure for the two main people handling and administering the cytotoxic agent during HIPEC. Methods. Samples of blood and urine were collected from one male surgeon and one female perfusionist during oxaliplatin-based HIPEC treatment with open abdomen coliseum technique on six consecutive patients with PC from CRC. Results. All blood samples analysed were below the detection limit of <0.05 nmol/L Pt, and the urine samples were all below the detection limit of <0.03 nmol/L Pt. Conclusions. There appears to be little or no risk of Pt exposure during HIPEC when the recommended protective garment is used and the safety considerations are followed.
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2.
  • Van der Speeten, Kurt, 1970-, et al. (författare)
  • Pharmacology of perioperative 5-fluorouracil
  • 2010
  • Ingår i: Journal of Surgical Oncology. - : Wiley. - 0022-4790 .- 1096-9098. ; 102:7, s. 730-735
  • Tidskriftsartikel (refereegranskat)abstract
    • Background The purpose of this study was to analyze our current pharmacologic data regarding the perioperative use of 5-fluorouracil in the treatment of peritoneal surface malignancies. Methods Twenty-nine patients with peritoneal carcinomatosis from appendiceal malignancy were included in this pharmacological study. Results In the nine patients who received early postoperative intraperitoneal chemotherapy, the area under the curve for intraperitoneal 5-fluorouracil was 43,000 (+20,300) µg/ml x minutes and for intravenous 5-fluorouracil was 157 (+99) µg/ml x minutes.  The area under the curve ratio was 422 (+360). In 20 patients who received intravenous 5-fluorouracil in the operating room intraperitoneal 5-fluorouracil levels maintained a higher level as compared to the intravenous drug level over the 90 minutes of drug sampling. The area under the curve ratio of peritoneal fluid to plasma was 2.3 (+1.3). The area under curve ratio of peritoneal fluid to tumor nodules was 9.9 (+9.8).  The area under the curve ratio of plasma to tumor nodules was 5.2 (+4.7). Conclusions By modulating the route or timing of administration of 5-fluorouracil, it becomes a pharmacologic advantageous molecule in patients with peritoneal carcinomatosis of an appendiceal malignancy. 5-fluorouracil remains the cornerstone of the perioperative management of peritoneal carcinomatosis of gastrointestinal origin.
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