| 1. |
- Daniel, Maria, et al.
(författare)
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Effect of Myocardial Infarction With Nonobstructive Coronary Arteries on Physical Capacity and Quality-of-Life
- 2017
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Ingår i: American Journal of Cardiology. - : Elsevier BV. - 0002-9149 .- 1879-1913. ; 120:3, s. 341-346
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Tidskriftsartikel (refereegranskat)abstract
- Patients with myocardial infarction with nonobstructive coronary arteries (MINOCA), including Takotsubo syndrome (TS), are considered to have a better survival compared with those with coronary heart disease (CHD). Studies of patients with MINOCA measuring physical and mental function including matched control groups are lacking. The aim of this study was to determine the physical capacity and quality of life in patients with MINOCA. One-hundred patients with MINOCA along with TS (25%) were investigated from 2007 to 2011. A bicycle exercise stress test was performed 6 weeks after hospitalization and QoL was investigated by the Short Form Survey 36 at 3 months' follow-up. Both a healthy and a CHD group that were age and gender matched were used as controls. The MINOCA group had a lower physical capacity (139 ± 42 W) compared with the healthy control group (167 ± 53 W, p <0.001) but better than the CHD control group (124 ± 39 W, p = 0.023). Patients with MINOCA had lower physical and mental component summary scores compared with the healthy controls (p <0.001) and lower mental component summary (p = 0.012), mental health (p = 0.016), and vitality (p = 0.008) scores compared with the CHD controls. In conclusion, the findings of this first study on exercise capacity and QoL in patients with MINOCA showed both physical and mental distress from 6 weeks to 3 months after the acute event similar to CHD controls and in some perspectives even lower scores especially in the mental component of QoL.
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| 2. |
- Kaufmann, Tobias, et al.
(författare)
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Common brain disorders are associated with heritable patterns of apparent aging of the brain
- 2019
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Ingår i: Nature Neuroscience. - : Nature Publishing Group. - 1097-6256 .- 1546-1726. ; 22:10, s. 1617-
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Tidskriftsartikel (refereegranskat)abstract
- Common risk factors for psychiatric and other brain disorders are likely to converge on biological pathways influencing the development and maintenance of brain structure and function across life. Using structural MRI data from 45,615 individuals aged 3-96 years, we demonstrate distinct patterns of apparent brain aging in several brain disorders and reveal genetic pleiotropy between apparent brain aging in healthy individuals and common brain disorders.
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| 3. |
- Nero, Daniella, et al.
(författare)
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Personality Traits in Patients with Myocardial Infarction with Nonobstructive Coronary Arteries.
- 2019
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Ingår i: The American journal of medicine. - : Elsevier BV. - 1555-7162 .- 0002-9343. ; 132:3, s. 374-381
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Tidskriftsartikel (refereegranskat)abstract
- The purpose of this study was to describe type A behavior pattern and trait anger in patients with myocardial infarction with nonobstructive coronary arteries (MINOCA) and compare them with patients with coronary heart disease and healthy controls. Type A behavior pattern and anger have been linked to coronary heart disease in previous studies. This is the first study to assess type A behavior pattern and trait anger in MINOCA patients.One hundred MINOCA patients, consecutively recruited during 2007-2011 at 5 coronary care units in Stockholm, were matched for sex and age to 100 coronary heart disease patients and 100 healthy controls. All participants completed the Bortner Rating Scale to quantify type A behavior pattern and the Spielberger Trait Anger Scale to quantify anger 3 months after the acute event.MINOCA patients' Bortner Rating Scale score was 70.9 ± 10.8 (mean ± SD) and Spielberger Trait Anger Scale score was 14 (12-17) (median; interquartile range). Coronary heart disease patients' Bortner Rating Scale score was 70.5 ± 10.2 and Spielberger Trait Anger Scale score was 14 (12-17). Healthy controls' Bortner Rating Scale score was 71.9 ± 9.1 and Spielberger Trait Anger Scale score was 13 (11-16).We found no significant differences in Bortner Rating Scale score and Spielberger Trait Anger Scale score among MINOCA, coronary heart disease patients, and healthy controls, regardless of whether total scores, subscales, or cutoffs were used to classify type A behavior pattern and trait anger. However, we cannot exclude the existence of an occasional episode of anger or mental stress in relation to the coronary event. This is the first study to assess type A behavior pattern and trait anger in patients with MINOCA, and future studies need to confirm the current findings before any firm conclusions can be made.
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| 4. |
- Alnaes, Dag, et al.
(författare)
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Brain Heterogeneity in Schizophrenia and Its Association With Polygenic Risk
- 2019
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Ingår i: JAMA psychiatry. - : AMER MEDICAL ASSOC. - 2168-6238 .- 2168-622X. ; 76:7, s. 739-748
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Tidskriftsartikel (refereegranskat)abstract
- ImportanceBetween-individual variability in brain structure is determined by gene-environment interactions, possibly reflecting differential sensitivity to environmental and genetic perturbations. Magnetic resonance imaging (MRI) studies have revealed thinner cortices and smaller subcortical volumes in patients with schizophrenia. However, group-level comparisons may mask considerable within-group heterogeneity, which has largely remained unnoticed in the literature. ObjectivesTo compare brain structural variability between individuals with schizophrenia and healthy controls and to test whether respective variability reflects the polygenic risk score (PRS) for schizophrenia in an independent sample of healthy controls. Design, Setting, and ParticipantsThis case-control and polygenic risk analysis compared MRI-derived cortical thickness and subcortical volumes between healthy controls and patients with schizophrenia across 16 cohorts and tested for associations between PRS and MRI features in a control cohort from the UK Biobank. Data were collected from October 27, 2004, through April 12, 2018, and analyzed from December 3, 2017, through August 1, 2018. Main Outcomes and MeasuresMean and dispersion parameters were estimated using double generalized linear models. Vertex-wise analysis was used to assess cortical thickness, and regions-of-interest analyses were used to assess total cortical volume, total surface area, and white matter, subcortical, and hippocampal subfield volumes. Follow-up analyses included within-sample analysis, test of robustness of the PRS threshold, population covariates, outlier removal, and control for image quality. ResultsA comparison of 1151 patients with schizophrenia (mean [SD] age,33.8[10.6] years; 68.6% male [n=790] and 31.4% female [n=361]) with 2010 healthy controls (mean [SD] age,32.6[10.4] years; 56.0% male [n=1126] and 44.0% female [n=884]) revealed higher heterogeneity in schizophrenia for cortical thickness and area (t = 3.34), cortical (t=3.24) and ventricle (t range, 3.15-5.78) volumes, and hippocampal subfields (t range, 2.32-3.55). In the UK Biobank sample of 12 490 participants (mean [SD] age,55.9 [7.5] years; 48.2% male [n=6025] and 51.8% female [n=6465]), higher PRS was associated with thinner frontal and temporal cortices and smaller left CA2/3 (t=-3.00) but was not significantly associated with dispersion. Conclusions and RelevanceThis study suggests that schizophrenia is associated with substantial brain structural heterogeneity beyond the mean differences. These findings may reflect higher sensitivity to environmental and genetic perturbations in patients, supporting the heterogeneous nature of schizophrenia. A higher PRS was associated with thinner frontotemporal cortices and smaller hippocampal subfield volume, but not heterogeneity. This finding suggests that brain variability in schizophrenia results from interactions between environmental and genetic factors that are not captured by the PRS. Factors contributing to heterogeneity in frontotemporal cortices and hippocampus are key to furthering our understanding of how genetic and environmental factors shape brain biology in schizophrenia.
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| 5. |
- Bradley, Karin, 1975-, et al.
(författare)
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Därför är ekonomisk tillväxt en risk
- 2016
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Ingår i: Dagens samhälle. - : Dagens Samhälle AB. - 1652-6511.
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Forskningsöversikt (populärvet., debatt m.m.)
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| 6. |
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| 9. |
- Hagbert, Pernilla, Dr, 1986-, et al.
(författare)
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Futures Beyond GDP Growth : Final report from the research program 'Beyond GDP Growth: Scenarios for sustainable building and planning'
- 2019
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Rapport (övrigt vetenskapligt/konstnärligt)abstract
- A future society no longer based on economic growth – what would that look like?The research program “Beyond GDP Growth: Scenarios for sustainable building and planning” (www.bortombnptillvaxt.se) is a strong research environment funded by the Swedish Research CouncilFormas, which has run between 2014 and 2018. In collaboration with societal partners, the program hasgathered researchers from diferent disciplines to explore key issues and conditions for planning for asustainable future beyond GDP growth. This is a relevant contribution to a largely under-researchedarea, where few scientific studies have explored what a sustainable society could look like, and what asustainable economy that is not based on growth might actually mean.In economic and political discussions, the notion of continuous economic growth is often taken forgranted and seen as a prerequisite for a safe and sustainable societal development. At the same time,a blind faith in and expectations surrounding growth can constitute a threat to the development of asustainable society if growth declines. Also an optimistic prognosis from the OECD indicates that it islikely that future GDP growth will be lower than what has come to be seen as the normal level duringthe second half of the 20th century. Declining economic growth could mean risks for increased socialgaps and unemployment. However, economic models show that the possibilities for handling these risksincrease if there is an awareness of them, and if this is addressed politically. Therefore, it is important tonot just assume continued economic growth, but to plan also for alternative scenarios.A starting point for the research program has been an understanding of the significant transitionsneeded to approach a safe and just operating space for humanity within planetary boundaries. Fourgoals that should be met in order to consider the societal development sustainable were specified: twoenvironmental goals related to climate and land use, and two social goals regarding power, influence andparticipation, and welfare and resource security.Four scenarios for Sweden 2050 were developed, which show the diferent directions society could taketo reach the set sustainability goals. The scenarios illustrate future societies that do not have to build onthe current economic logic, but that instead are centred around four alternative strategies:Collaborative EconomyLocal Self-SufciencyAutomation for Quality of LifeCircular Economy in the Welfare StateSo, can we reach the selected sustainability targets in the four future scenarios? A transformation ofhistorical proportions are needed – and it needs to start immediately. According to the sustainabilityassessment conducted within the project, the environmental goals of climate and land use can be reachedin all scenarios, even though it demands changing multiple parameters at the same time. Nothing pointsto it being impossible or generally difcult to achieve the social goals in the four scenarios, however theremight be diferent aspects that are particularly tricky. There are both development potentials and risks,which can be diametrically opposite for diferent social groups and parts of the country, depending onthe local prerequisites.Many diferent images of sustainable futures are needed. The scenarios should be seen as a tool fordiscussion and analysis when it comes to planning for a sustainable societal development beyondGDP growth. They challenge notions of what is possible, what changes that can and should be made,6what decisions that are needed and what should be prioritized. The scenarios all suggest a largechange compared the current development trajectory, and for example all point towards the need forredistribution of resources. It might involve economic resources, but could also relate to power andinfluence over production, or the possibility to use land for production of food, materials and energy.This redistribution could happen according to diferent principles in the diferent scenarios.In all the scenarios, the consumption of goods and of meat is reduced. Flight travel also needs to bedrastically reduced to reach the climate target. There is furthermore a need for reducing the constructionof both housing and road infrastructure, although to varying extents in the four scenarios. Other aspectssuch as working hours, the organization of welfare systems, the characteristics of the built environmentand the amount of infrastructure needed are on the other hand diferent in the diferent scenarios.The research program has explored what a development that isn't based on economic growth, in linewith the strategies that are depicted in the scenarios, would mean for rural as well as urban conditions.Three case study municipalities were selected with regards to their diferent geographical location,built form, economic development and size of the population: Övertorneå, Alingsås and Malmö. Insome sub-studies in these diferent contexts, descriptions emerged of cognitive as well as structuralbarriers, a sense of powerlessness and a weak capacity for transition among diferent actors. This isconnected to expectations and general assumptions regarding growth, partly irrespective of the context.Municipalities and companies to a large extent plan for and expect a societal development that buildsupon a further expansion of infrastructure, transport and consumption. Despite visions for sustainabledevelopment, in practice this often leads to a reproduction of current unsustainable structures and waysof life.At the same time, specific empirical studies within the project point toward stories of self-sufciency,of regional upswings and that the population is more important than GDP. There is an increasedawareness and a multitude of examples of experimenting with new sustainable practices that constituteseeds for change. Critiques against planning for continuous growth is being taken more seriously andclearer political visions are demanded. New forms of organizing the economy, society and welfare arealso being developed. Some examples include working from a perspective on socio-ecological justice,integration of sustainability targets in all planning, and developing new roles for consumers andproducers. These ideas can be seen as windows of opportunity, but also show that change can happenwithin the current system.The future means change. In this research program, we point towards some possible futures that aimat reaching certain sustainability targets. The scenarios and the discussion and analysis that they havebrought about show that there is an opportunity to move towards a sustainable development withmaintained or even increased well-being – provided that the understanding of well-being is based onother values than those of our current society. For these possible future trajectories to gain support,there is a need of political instruments and measures that actively drive the development towards a justand safe operating space for humanity
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| 10. |
- Hjort, Marcus, et al.
(författare)
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Increased Inflammatory Activity in Patients 3 Months after Myocardial Infarction with Nonobstructive Coronary Arteries
- 2019
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Ingår i: Clinical Chemistry. - : AMER ASSOC CLINICAL CHEMISTRY. - 0009-9147 .- 1530-8561. ; 65:8, s. 1023-1030
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Tidskriftsartikel (refereegranskat)abstract
- BACKGROUND: Around 5%-10% of patients with myocardial infarction (MI) present with nonobstructive coronary arteries (MINOCA). We aimed to assess pathophysiological mechanisms in MINOCA by extensively evaluating cardiovascular biomarkers in the stable phase after an event, comparing MINOCA patients with cardiovascular healthy controls and MI patients with obstructive coronary artery disease (MI-CAD).METHODS: Ninety-one biomarkers were measured with a proximity extension assay 3 months after MI in 97 MINOCA patients, 97 age-and sex-matched MI-CAD patients, and 98 controls. Lasso analyses (penalized logistic regression models) and adjusted multiple linear regression models were used for statistical analyses.RESULTS: In the Lasso analysis (MINOCA vs MI-CAD), 8 biomarkers provided discriminatory value: P-selectin glycoprotein ligand 1, C-X-C motif chemokine 1, TNF-related activation-induced cytokine, and pappalysin-1 (PAPPA) with increasing probabilities of MINOCA, and tissue-type plasminogen activator, B-type natriuretic peptide, myeloperoxidase, and interleukin-1 receptor antagonist protein with increasing probabilities of MI-CAD. Comparing MINOCA vs controls, 7 biomarkers provided discriminatory value: N-terminal pro-B-type natriuretic peptide, renin, NF-kappa-B essential modulator, PAPPA, interleukin-6, and soluble urokinase plasminogen activator surface receptor with increasing probabilities of MINOCA, and agouti-related protein with increasing probabilities of controls. Adjusted multiple linear regression analyses showed that group affiliation was associated with the concentrations of 7 of the 8 biomarkers in the comparison MINOCA vs MI-CAD and 5 of the 7 biomarkers in MINOCA vs controls.CONCLUSIONS: Three months after the MI, the biomarker concentrations indicated greater inflammatory activity in MINOCA patients than in both MI-CAD patients and healthy controls, and a varying degree of myocardial dysfunction among the 3 cohorts.
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