Tyck till om SwePub Sök
här!
Search: WFRF:(Martin Lynn)
> (2006) >
Interferon (IFN)-ga...
Interferon (IFN)-gamma-inducible protein-10: association with histological results, viral kinetics, and outcome during treatment with pegylated IFN-alpha 2a and ribavirin for chronic hepatitis C virus infection
-
- Romero, Ana, 1975 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för biomedicin, avdelningen för infektionssjukdomar,Institute of Biomedicine, Department of Infectious Medicine
-
- Lagging, Martin, 1965 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för biomedicin, avdelningen för infektionssjukdomar,Institute of Biomedicine, Department of Infectious Medicine
-
- Westin, Johan, 1965 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för biomedicin, avdelningen för infektionssjukdomar,Institute of Biomedicine, Department of Infectious Medicine
-
show more...
-
Dhillon, Amar P (author)
-
Dustin, Lynn B (author)
-
Pawlotsky, Jean-Michel (author)
-
Neumann, Avidan U (author)
-
Ferrari, Carlo (author)
-
Missale, Gabriele (author)
-
Haagmans, Bart L (author)
-
Schalm, Solko W (author)
-
Zeuzem, Stefan (author)
-
Negro, Francesco (author)
-
Verheij-Hart, Elke (author)
-
- Hellstrand, Kristoffer, 1956 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för biomedicin, avdelningen för infektionssjukdomar,Institute of Biomedicine, Department of Infectious Medicine
-
show less...
-
(creator_code:org_t)
- 2006
- 2006
- English.
-
In: J Infect Dis. - 0022-1899. ; 194:7, s. 895-903
- Related links:
-
https://gup.ub.gu.se...
Abstract
Subject headings
Close
- BACKGROUND: We investigated associations between interferon (IFN)-gamma-inducible protein (IP)-10 and liver histological results, viral kinetic response, and treatment outcome in patients infected with hepatitis C virus (HCV) genotypes 1-4. METHODS: Plasma IP-10 was monitored before, during, and after treatment with pegylated IFN- alpha 2a and ribavirin in 265 HCV-infected patients. RESULTS: In univariate analyses, a low baseline IP-10 level was significantly associated with low baseline viral load, rapid viral response (RVR), a sustained viral response (SVR), body mass index <25 kg/m2, and less-pronounced fibrosis, inflammation, and steatosis (for HCV genotypes other than 3). When the results of the univariate analyses were included in multivariate analyses, a low plasma IP-10 level, low baseline viral load, and genotype 2 or 3 infection were independent predictors of an RVR and SVR. IP-10 levels decreased 6 weeks into treatment and remained low in patients with an SVR. By contrast, plasma levels of IP-10 rebounded in patients who had detectable HCV RNA after the completion of treatment. Using cutoff IP-10 levels of 150 and 600 pg/mL for predicting an SVR in patients infected with HCV genotype 1 yielded a specificity and sensitivity of 81% and 95%, respectively. CONCLUSION: Baseline IP-10 levels are predictive of the response to HCV treatment.
Keyword
- Adult
- Antiviral Agents/ therapeutic use
- Chemokines
- CXC/ blood
- Drug Therapy
- Combination
- Female
- Hepacivirus/drug effects/ physiology
- Hepatitis C
- Chronic/ drug therapy/virology
- Humans
- Interferon Alfa-2a/therapeutic use
- Interferon Type II/ pharmacology
- Liver/pathology
- Male
- Middle Aged
- Polyethylene Glycols/therapeutic use
- RNA
- Viral/blood
- Ribavirin/therapeutic use
- Treatment Outcome
- Viral Load
Publication and Content Type
- ref (subject category)
- art (subject category)
Find in a library
To the university's database
- By the author/editor
-
Romero, Ana, 197 ...
-
Lagging, Martin, ...
-
Westin, Johan, 1 ...
-
Dhillon, Amar P
-
Dustin, Lynn B
-
Pawlotsky, Jean- ...
-
show more...
-
Neumann, Avidan ...
-
Ferrari, Carlo
-
Missale, Gabriel ...
-
Haagmans, Bart L
-
Schalm, Solko W
-
Zeuzem, Stefan
-
Negro, Francesco
-
Verheij-Hart, El ...
-
Hellstrand, Kris ...
-
show less...
- Articles in the publication
-
J Infect Dis
- By the university
-
University of Gothenburg