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Interferon (IFN)-ga...
Interferon (IFN)-gamma-inducible protein-10: association with histological results, viral kinetics, and outcome during treatment with pegylated IFN-alpha 2a and ribavirin for chronic hepatitis C virus infection
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- Romero, Ana, 1975 (författare)
- Gothenburg University,Göteborgs universitet,Institutionen för biomedicin, avdelningen för infektionssjukdomar,Institute of Biomedicine, Department of Infectious Medicine
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- Lagging, Martin, 1965 (författare)
- Gothenburg University,Göteborgs universitet,Institutionen för biomedicin, avdelningen för infektionssjukdomar,Institute of Biomedicine, Department of Infectious Medicine
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- Westin, Johan, 1965 (författare)
- Gothenburg University,Göteborgs universitet,Institutionen för biomedicin, avdelningen för infektionssjukdomar,Institute of Biomedicine, Department of Infectious Medicine
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Dhillon, Amar P (författare)
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Dustin, Lynn B (författare)
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Pawlotsky, Jean-Michel (författare)
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Neumann, Avidan U (författare)
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Ferrari, Carlo (författare)
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Missale, Gabriele (författare)
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Haagmans, Bart L (författare)
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Schalm, Solko W (författare)
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Zeuzem, Stefan (författare)
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Negro, Francesco (författare)
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Verheij-Hart, Elke (författare)
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- Hellstrand, Kristoffer, 1956 (författare)
- Gothenburg University,Göteborgs universitet,Institutionen för biomedicin, avdelningen för infektionssjukdomar,Institute of Biomedicine, Department of Infectious Medicine
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(creator_code:org_t)
- 2006
- 2006
- Engelska.
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Ingår i: J Infect Dis. - 0022-1899. ; 194:7, s. 895-903
- Relaterad länk:
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https://gup.ub.gu.se...
Abstract
Ämnesord
Stäng
- BACKGROUND: We investigated associations between interferon (IFN)-gamma-inducible protein (IP)-10 and liver histological results, viral kinetic response, and treatment outcome in patients infected with hepatitis C virus (HCV) genotypes 1-4. METHODS: Plasma IP-10 was monitored before, during, and after treatment with pegylated IFN- alpha 2a and ribavirin in 265 HCV-infected patients. RESULTS: In univariate analyses, a low baseline IP-10 level was significantly associated with low baseline viral load, rapid viral response (RVR), a sustained viral response (SVR), body mass index <25 kg/m2, and less-pronounced fibrosis, inflammation, and steatosis (for HCV genotypes other than 3). When the results of the univariate analyses were included in multivariate analyses, a low plasma IP-10 level, low baseline viral load, and genotype 2 or 3 infection were independent predictors of an RVR and SVR. IP-10 levels decreased 6 weeks into treatment and remained low in patients with an SVR. By contrast, plasma levels of IP-10 rebounded in patients who had detectable HCV RNA after the completion of treatment. Using cutoff IP-10 levels of 150 and 600 pg/mL for predicting an SVR in patients infected with HCV genotype 1 yielded a specificity and sensitivity of 81% and 95%, respectively. CONCLUSION: Baseline IP-10 levels are predictive of the response to HCV treatment.
Nyckelord
- Adult
- Antiviral Agents/ therapeutic use
- Chemokines
- CXC/ blood
- Drug Therapy
- Combination
- Female
- Hepacivirus/drug effects/ physiology
- Hepatitis C
- Chronic/ drug therapy/virology
- Humans
- Interferon Alfa-2a/therapeutic use
- Interferon Type II/ pharmacology
- Liver/pathology
- Male
- Middle Aged
- Polyethylene Glycols/therapeutic use
- RNA
- Viral/blood
- Ribavirin/therapeutic use
- Treatment Outcome
- Viral Load
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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Till lärosätets databas
- Av författaren/redakt...
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Romero, Ana, 197 ...
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Lagging, Martin, ...
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Westin, Johan, 1 ...
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Dhillon, Amar P
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Dustin, Lynn B
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Pawlotsky, Jean- ...
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visa fler...
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Neumann, Avidan ...
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Ferrari, Carlo
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Missale, Gabriel ...
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Haagmans, Bart L
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Schalm, Solko W
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Zeuzem, Stefan
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Negro, Francesco
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Verheij-Hart, El ...
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Hellstrand, Kris ...
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- Artiklar i publikationen
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J Infect Dis
- Av lärosätet
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Göteborgs universitet