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Träfflista för sökning "WFRF:(Norrgren Hans) srt2:(2000-2004)"

Sökning: WFRF:(Norrgren Hans) > (2000-2004)

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  • Norrgren, Hans, et al. (författare)
  • Clinical progression in early and late stages of disease in a cohort of individuals infected with human immunodeficiency virus-2 in Guinea-Bissau
  • 2003
  • Ingår i: Scandinavian Journal of Infectious Diseases. - : Informa UK Limited. - 1651-1980 .- 0036-5548. ; 35:4, s. 265-272
  • Tidskriftsartikel (refereegranskat)abstract
    • The aim of this study was to assess the rate of clinical progression to early and late stages of human immunodeficiency virus-2 (HIV-2) infection. CD4 cell counts and other potential prognostic markers for disease progression were also evaluated. In January 1990 an open prospective cohort of police officers in Guinea-Bissau was initiated with yearly serological and clinical follow-up. Follow-up ended in June 1998. Symptoms were classified according to the World Health Organization staging system. The analysis included 148 HIV-2-seropositive subjects and 177 HIV-seronegative controls. 25 of the HIV-2-positive individuals were seroconverters (seroincident cases). The progression rate to stage 3 of HIV-2-positive subjects in stage 1 + 2 was 8.6/100 person-years (py) ( rate ratio 6.2 compared with HIV-negative controls, 95% confidence interval 2.7 - 14.2, p< 0.001), and the progression rate to stage 4, i.e. acquired immunodeficiency syndrome ( AIDS), was 2.1/100 py. HIV-2-positive people in stage 3 at inclusion progressed to AIDS at a rate of 16.9/100 py. CD4% &LE; 20 was found to be a significant prognostic marker for progression to stage 4, both from stage 1 + 2 and from stage 3. The clinical progression in this cohort of HIV-2-infected subjects was generally lower than that in HIV-1-positive cohorts.
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