SwePub
Sök i SwePub databas

  Utökad sökning

Träfflista för sökning "WFRF:(O''Brien John) ;srt2:(2005-2009)"

Sökning: WFRF:(O''Brien John) > (2005-2009)

  • Resultat 21-23 av 23
Sortera/gruppera träfflistan
   
NumreringReferensOmslagsbildHitta
21.
  • Ropele, Stefan, et al. (författare)
  • Quantitation of brain tissue changes associated with white matter hyperintensities by diffusion-weighted and magnetization transfer imaging: the LADIS (Leukoaraiosis and Disability in the Elderly) study.
  • 2009
  • Ingår i: Journal of magnetic resonance imaging : JMRI. - : Wiley. - 1053-1807 .- 1522-2586. ; 29:2, s. 268-74
  • Tidskriftsartikel (refereegranskat)abstract
    • PURPOSE: To explore the value of diffusion-weighted imaging (DWI) and magnetization transfer imaging (MTI) for the improved detection and quantification of cerebral tissue changes associated with ageing and white matter hyperintensities (WMH). MATERIALS AND METHODS: DWI (n = 340) and MTI (n = 177) were performed in nine centers of the multinational Leukoaraiosis And DISability (LADIS) study investigating the impact of WMH on 65- to 85-year-old individuals without prior disability. We assessed the apparent diffusion coefficient (ADC) and magnetization transfer ratio (MTR) of normal appearing brain tissue (NABT) and within WMH and related them to subjects' age and WHM severity according to the Fazekas score. RESULTS: ADC and MTR values showed a significant inter-site variation, which was stronger for the MTR. After z-transformation multiple regression analysis revealed WMH severity and age as significant predictors of global ADC and MTR changes. Only lesional ADC, but not MTR was related to WMH severity. CONCLUSION: ADC and MTR are both sensitive for age and WMH related changes in NABT. The ADC is more sensitive for tissue changes within WMH and appears to be more robust for multicenter settings.
  •  
22.
  •  
23.
  • Vesikari, Timo, et al. (författare)
  • Safety and efficacy of a pentavalent human-bovine (WC3) reassortant rotavirus vaccine.
  • 2006
  • Ingår i: N Engl J Med. - 1533-4406. ; 354:1, s. 23-33
  • Tidskriftsartikel (refereegranskat)abstract
    • BACKGROUND: Rotavirus is a leading cause of childhood gastroenteritis and death worldwide. METHODS: We studied healthy infants approximately 6 to 12 weeks old who were randomly assigned to receive three oral doses of live pentavalent human-bovine (WC3 strain) reassortant rotavirus vaccine containing human serotypes G1, G2, G3, G4, and P[8] or placebo at 4-to-10-week intervals in a blinded fashion. Active surveillance was used to identify subjects with serious adverse and other events. RESULTS: The 34,035 infants in the vaccine group and 34,003 in the placebo group were monitored for serious adverse events. Intussusception occurred in 12 vaccine recipients and 15 placebo recipients within one year after the first dose including six vaccine recipients and five placebo recipients within 42 days after any dose (relative risk, 1.6; 95 percent confidence interval, 0.4 to 6.4). The vaccine reduced hospitalizations and emergency department visits related to G1-G4 rotavirus gastroenteritis occurring 14 or more days after the third dose by 94.5 percent (95 percent confidence interval, 91.2 to 96.6 percent). In a nested substudy, efficacy against any G1-G4 rotavirus gastroenteritis through the first full rotavirus season after vaccination was 74.0 percent (95 percent confidence interval, 66.8 to 79.9 percent); efficacy against severe gastroenteritis was 98.0 percent (95 percent confidence interval, 88.3 to 100 percent). The vaccine reduced clinic visits for G1-G4 rotavirus gastroenteritis by 86.0 percent (95 percent confidence interval, 73.9 to 92.5 percent). CONCLUSIONS: This vaccine was efficacious in preventing rotavirus gastroenteritis, decreasing severe disease and health care contacts. The risk of intussusception was similar in vaccine and placebo recipients. (ClinicalTrials.gov number, NCT00090233.) Copyright 2006 Massachusetts Medical Society.
  •  
Skapa referenser, mejla, bekava och länka
  • Resultat 21-23 av 23
Typ av publikation
tidskriftsartikel (23)
Typ av innehåll
refereegranskat (23)
Författare/redaktör
Pantoni, Leonardo (15)
Erkinjuntti, Timo (15)
Inzitari, Domenico (15)
Wallin, Anders, 1950 (14)
Waldemar, Gunhild (12)
Chabriat, Hugues (12)
visa fler...
O'Brien, John (12)
Visser, Marieke C. (12)
Wahlund, Lars-Olof (11)
Scheltens, Philip (11)
Hennerici, Michael (11)
Fazekas, Franz (11)
Basile, Anna Maria (7)
Pracucci, Giovanni (7)
Ferro, José M. (7)
Barkhof, Frederik (6)
Langhorne, Peter (4)
Schmidt, Reinhold (4)
van der Flier, Wiesj ... (3)
Asplund, Kjell (3)
Wareham, Nick (2)
Riboli, Elio (2)
Tendera, Michal (2)
Widimsky, Petr (2)
Tamargo, Juan (2)
Zamorano, Jose Luis (2)
Dean, Veronica (2)
Ponikowski, Piotr (2)
Nilsson, Peter M (2)
Filippatos, Gerasimo ... (2)
Adamopoulos, Stamati ... (2)
Ruschitzka, Frank (2)
O'Brien, Eoin (2)
Vineis, Paolo (2)
Laurent, Stephane (2)
Boffetta, Paolo (2)
Jarvelin, Marjo-Riit ... (2)
De Caterina, Raffael ... (2)
Bernstein, Jonine L. (2)
Bondy, Melissa (2)
Malmer, Beatrice (2)
Dickstein, Kenneth (2)
Gruis, Nelleke A (2)
Newton-Bishop, Julia ... (2)
Seminara, Daniela (2)
Uitterlinden, André ... (2)
Ioannidis, John P. A ... (2)
Lindholm, Lars H (2)
Viigimaa, Margus (2)
De Backer, Guy (2)
visa färre...
Lärosäte
Göteborgs universitet (15)
Karolinska Institutet (15)
Umeå universitet (7)
Lunds universitet (2)
Uppsala universitet (1)
Språk
Engelska (23)
Forskningsämne (UKÄ/SCB)
Medicin och hälsovetenskap (14)

År

Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.

 
pil uppåt Stäng

Kopiera och spara länken för att återkomma till aktuell vy