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| 2. |
- Gavali, Hamid, et al.
(författare)
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Outcome of Radical Surgical Treatment of Abdominal Aortic Graft and Endograft Infections Comparing Extra-anatomic Bypass with In Situ Reconstruction : A Nationwide Multicentre Study
- 2021
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Ingår i: European Journal of Vascular and Endovascular Surgery. - : Saunders Elsevier. - 1078-5884 .- 1532-2165. ; 62:6, s. 918-926
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Tidskriftsartikel (refereegranskat)abstract
- Objective: Abdominal aortic graft and endograft infection (AGI) is primarily treated by resection of the infected graft and restoration of distal perfusion through extra-anatomic bypass (EAB) or in situ reconstruction/repair (ISR). The aim of this study was to compare these surgical strategies in a nationwide multicentre retrospective cohort study.Methods: The Swedish Vascular Registry (Swedvasc) was used to identify surgically treated abdominal AGIs in Sweden between January 1995 and May 2017. The primary aim was to compare short and long term survival, as well as complications for EAB and ISR.Results: Some 126 radically surgically treated AGI patients were identified – 102 graft infections and 24 endograft infections – treated by EAB: 71 and ISR: 55 (23 neo-aorto-iliac systems, NAISs). No differences in early 30 day (EAB 81.7% vs. ISR 76.4%, p =.46), or long term five year survival (48.2% vs. 49.9%, p =.87) were identified. There was no survival difference comparing NAIS to other ISR strategies. The frequency of recurrent graft infection during follow up was similar: EAB 20.3% vs. ISR 17.0% (p =.56). Survival and re-infection rates of the new conduit did not differ between NAIS and other ISR strategies. Age ≥ 75 years (odds ratio [OR] 4.0, confidence interval [CI] 1.1 – 14.8), coronary artery disease (OR 4.2, CI 1.2 – 15.1) and post-operative circulatory complications (OR 5.2, CI 1.2 – 22.5) were associated with early death. Prolonged antimicrobial therapy (> 3 months) was associated with reduced long term mortality (HR 0.3, CI 0.1 – 0.9).Conclusion: In this nationwide multicentre study comparing outcomes of radically treated AGI, no differences in survival or re-infection rate could be identified comparing EAB and ISR.
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| 3. |
- Wamsler, Christine, et al.
(författare)
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Environmental and climate policy integration: Targeted strategies for overcoming barriers to nature-based solutions and climate change adaptation
- 2020
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Ingår i: Journal of Cleaner Production. - : Elsevier BV. - 0959-6526. ; 247, s. 119-154
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Tidskriftsartikel (refereegranskat)abstract
- Nature-based adaptation planning is a challenging endeavor, not least because it requires transdisciplinary approaches to unite different actors' efforts and capacities. However, empirical knowledge on associated governance processes is scarce and fragmented. Against this background, this paper examines the integration of nature-based approaches for climate change adaptation into municipalities’ daily planning practices and associated governance. A city-to-city learning lab was established to systematically analyze selected urban development projects step-by-step, from the initial idea, to comprehensive and detailed planning, procurement, implementation, maintenance and follow-up. The results show the numerous constraints municipal staff face and how they use targeted strategies to overcome them and tap into existing drivers. We identify five, complementary strategies: i) targeted stakeholder collaboration; ii) strategic citizen involvement; iii) outsourcing; iv) the alteration of internal working structures; and v) concealed science–policy integration. Importantly, these strategies reveal an increasing need for relational approaches that, in turn, require individuals to develop the cognitive/emotional capacity to establish trust, communicate inclusively and promote social learning, while at the same time dealing with an increasingly complex and uncertain working environment. We conclude that tapping into the potential of nature-based solutions for climate adaptation governance requires more financial and human resources, and capacity development to support personal development, systematic mainstreaming and, ultimately, more sustainable development.
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| 4. |
- Abdellah, Tebani, et al.
(författare)
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Integration of molecular profiles in a longitudinal wellness profiling cohort.
- 2020
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Ingår i: Nature communications. - : Springer Science and Business Media LLC. - 2041-1723. ; 11:1
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Tidskriftsartikel (refereegranskat)abstract
- An important aspect of precision medicine is to probe the stability in molecular profiles among healthy individuals over time. Here, we sample a longitudinal wellness cohort with 100 healthy individuals and analyze blood molecular profiles including proteomics, transcriptomics, lipidomics, metabolomics, autoantibodies and immune cell profiling, complemented with gut microbiota composition and routine clinical chemistry. Overall, our results show high variation between individuals across different molecular readouts, while the intra-individual baseline variation is low. The analyses show that each individual has a unique and stable plasma protein profile throughout the study period and that many individuals also show distinct profiles with regards to the other omics datasets, with strong underlying connections between the blood proteome and the clinical chemistry parameters. In conclusion, the results support an individual-based definition of health and show that comprehensive omics profiling in a longitudinal manner is a path forward for precision medicine.
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| 6. |
- Baqué, Mickael, et al.
(författare)
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Biosignature stability in space enables their use for life detection on Mars
- 2022
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Ingår i: Science Advances. - : NLM (Medline). - 2375-2548. ; 8:36
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Tidskriftsartikel (refereegranskat)abstract
- Two rover missions to Mars aim to detect biomolecules as a sign of extinct or extant life with, among other instruments, Raman spectrometers. However, there are many unknowns about the stability of Raman-detectable biomolecules in the martian environment, clouding the interpretation of the results. To quantify Raman-detectable biomolecule stability, we exposed seven biomolecules for 469 days to a simulated martian environment outside the International Space Station. Ultraviolet radiation (UVR) strongly changed the Raman spectra signals, but only minor change was observed when samples were shielded from UVR. These findings provide support for Mars mission operations searching for biosignatures in the subsurface. This experiment demonstrates the detectability of biomolecules by Raman spectroscopy in Mars regolith analogs after space exposure and lays the groundwork for a consolidated space-proven database of spectroscopy biosignatures in targeted environments.
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| 7. |
- Berggren, Peter, et al.
(författare)
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Coping with large disruptions in the payment system : stakeholder experience from stakeholder workshops and computer based simulation gaming exercises
- 2020
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Ingår i: Proceedings of the 2020 the 3rd International Conference on Computers in Management and Business (ICCMB 2020) Session - Computer and Mobile Technology. - New York : Association for Computing Machinery (ACM). - 9781450376778 ; , s. 141-145, s. 141-145
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Konferensbidrag (refereegranskat)abstract
- In this paper, we describe a work in progress where a mixed methods approach is used to increase insight into what kind of consequences a temporal disruption or total breakdown of the payment system creates for a large variety of societal actors and to increase insight in how their collaborative behaviour can be guided to be more resilient. This approach includes data from different types of data collections; workshop with high-level decisionmakers from involved sectors, interviews with citizens, representatives from the fuel, foods, and finance sectors, as well as experiences from 15 simulation game exercises with stakeholders. The triangulated and aggregated outcomes of the different data collections resulted in a set of recommendations on how to cope with disruptions in the card payment system.
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| 8. |
- Bergsten, Linnea, et al.
(författare)
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Designing engaging computer based simulation games for increasing societal resilience to payment system
- 2020
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Ingår i: Proceedings of the 2020 the 3rd International Conference on Computers in Management and Business (ICCMB 2020) Session - Computer and Mobile Technology. - New York : Association for Computing Machinery (ACM). - 9781450376778 ; , s. 166-172, s. 166-172
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Konferensbidrag (refereegranskat)abstract
- Large or lengthy disruptions to the card payment system are threats that can cause crisis in society, especially in countries where other payment options are scarce. This paper presents a study that provides suggestions on how to improve a simulation game used to increase societal resilience to payment system disruptions. Questionnaires and interviews have been used to investigate how 16 participant in crisis exercises experience realism, relevance and validity in such exercises. Suggestions on how to improve the simulation game are provided, such as improvements to the graphical interface and introducing supporting roles from the exercise management.
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| 9. |
- Blomqvist, Niklas, 1987-
(författare)
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Essays on Labor Economics : The Role of Government in Labor Supply Choices
- 2020
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Doktorsavhandling (övrigt vetenskapligt/konstnärligt)abstract
- "Right to Work Full-time" Policies and Involuntary Part-time EmploymentThis paper investigates the effect of right to full-time policies implemented to decrease involuntary part-time work for public care workers employed by Swedish municipalities. Taking advantage of a staggered decision process, these policies are evaluated using a difference-in-differences approach. Results show that involuntary part-time employment is real and significant, with 10% of part-time employed workers choosing full-time when given the opportunity. The effect mainly comes from a decrease in contracts of <75% of full-time and an increase in contracts of 80% of full-time and above. Further results from the full-time policies show that being more flexible in the choice of hours worked is popular among workers, indicated by an increase in tenure and reduced turnover in municipalities that offer more flexibility in the choice of hours worked.Hours Constraints and Tax Elasticity Estimates - Evidence from Swedish Public Care WorkersThere is a concern that tax elasticity estimates may be downward biased in the presence of optimization frictions for workers. So far, there is limited evidence on the nature of these optimization frictions. This paper provides new insight into one part of the optimization frictions black box, namely hours constraints. Using unique and newly collected data, I exploit a staggered implementation of a policy that gave some public care workers the opportunity to choose their preferred hours of work. Taking advantage of this policy, I estimate differences in tax elasticities between constrained and unconstrained public care workers by comparing bunching at a large tax kink in the Swedish tax system. The empirical evidence points to the conclusion that hours constraints do not affect tax elasticity estimates.Restricting Residence Permits - Short-Run Evidence from a Swedish ReformIn June 2016, the Swedish parliament decided to restrict the granting of permanent residence permits for asylum seekers in Sweden. The new status quo for a refugee is a temporary rather than a permanent residence permit. In a first evaluation of this reform we use a Regression discontinuity analysis in which we follow refugees, aged 25-65, over their first years after arrival. Our main results show that a temporary residence permit increases the probability of working and enrolling in regular education.Mom and Dad Got Jobs: Natural Resources, Economic Activity, and Infant HealthThe impact of local economic shocks, such as the discovery and exploitation of natural resources, on labor markets and health is not well understood. Both positive and negative effects have been documented in the literature. In this paper, we show that the phase before active resource extraction begins directly affects the local economy. This implies that previous estimates – typically based on designs exploiting differences before and after the active phase of extraction begins - may have understated the actual effect of natural resource extraction on outcomes of interest. Using rich data from Sweden combined with differences in the timing and location of mineral exploitation permits, we find a positive impact on female and male employment and earnings and a negative effect on housing prices. Children’s health outcomes are also negatively affected, an effect likely driven by the increase in local economic activity rather than extraction-related externalities.
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| 10. |
- Bohman, Anna, 1975-, et al.
(författare)
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Visual Water : En visualiseringsplattform för dagvatten- och skyfallsplanering i ett klimat under förändring
- 2021
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Rapport (övrigt vetenskapligt/konstnärligt)abstract
- Visual Water (http//visualwater.se) är en interaktiv webbaserad visualiseringsplattform som syftar till att stötta svenska kommuner i arbetet för en hållbar dagvatten- och skyfallshantering. Plattformen är utformad för att svara mot centrala utmaningar som lyfts av svenska dagvattenaktörer som befinner sig i skiftet bort från de rörbundna nätverksidealen för avledning av dagvatten och strävar efter en högre grad av grön-blå och öppna lösningar i stadsmiljön.
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