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Träfflista för sökning "WFRF:(Oostra Ben A.) srt2:(2017)"

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Numrering	Referens	Omslagsbild	Hitta
1.	Hudson, Lawrence N, et al. (författare) The database of the PREDICTS (Projecting Responses of Ecological Diversity In Changing Terrestrial Systems) project 2017 Ingår i: Ecology and Evolution. - : John Wiley & Sons. - 2045-7758. ; 7:1, s. 145-188 Tidskriftsartikel (refereegranskat)abstract The PREDICTS project-Projecting Responses of Ecological Diversity In Changing Terrestrial Systems (www.predicts.org.uk)-has collated from published studies a large, reasonably representative database of comparable samples of biodiversity from multiple sites that differ in the nature or intensity of human impacts relating to land use. We have used this evidence base to develop global and regional statistical models of how local biodiversity responds to these measures. We describe and make freely available this 2016 release of the database, containing more than 3.2 million records sampled at over 26,000 locations and representing over 47,000 species. We outline how the database can help in answering a range of questions in ecology and conservation biology. To our knowledge, this is the largest and most geographically and taxonomically representative database of spatial comparisons of biodiversity that has been collated to date; it will be useful to researchers and international efforts wishing to model and understand the global status of biodiversity.
2.	Zillikens, M Carola, et al. (författare) Erratum: Large meta-analysis of genome-wide association studies identifies five loci for lean body mass. 2017 Ingår i: Nature communications. - : Springer Science and Business Media LLC. - 2041-1723. ; 8:1 Tidskriftsartikel (refereegranskat)abstract A correction to this article has been published and is linked from the HTML version of this article.
3.	Wain, Louise V., et al. (författare) Novel Blood Pressure Locus and Gene Discovery Using Genome-Wide Association Study and Expression Data Sets From Blood and the Kidney 2017 Ingår i: Hypertension. - 0194-911X .- 1524-4563. ; 70:3, s. e4-e19 Tidskriftsartikel (refereegranskat)abstract Elevated blood pressure is a major risk factor for cardiovascular disease and has a substantial genetic contribution. Genetic variation influencing blood pressure has the potential to identify new pharmacological targets for the treatment of hypertension. To discover additional novel blood pressure loci, we used 1000 Genomes Project-based imputation in 150 134 European ancestry individuals and sought significant evidence for independent replication in a further 228 245 individuals. We report 6 new signals of association in or near HSPB7, TNXB, LRP12, LOC283335, SEPT9, and AKT2, and provide new replication evidence for a further 2 signals in EBF2 and NFKBIA. Combining large whole-blood gene expression resources totaling 12 607 individuals, we investigated all novel and previously reported signals and identified 48 genes with evidence for involvement in blood pressure regulation that are significant in multiple resources. Three novel kidney-specific signals were also detected. These robustly implicated genes may provide new leads for therapeutic innovation.

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Typ av publikation: tidskriftsartikel (3)

Typ av innehåll: refereegranskat (3)

Författare/redaktör: Khaw, Kay-Tee (2); Salomaa, Veikko (2); Jula, Antti (2); Perola, Markus (2); Lind, Lars (2); Campbell, Harry (2); visa fler...; Rudan, Igor (2); Wareham, Nicholas J. (2); Amin, Najaf (2); van Duijn, Cornelia ... (2); Boehnke, Michael (2); Ripatti, Samuli (2); Tuomilehto, Jaakko (2); Hylander, Kristoffer (1); Hoffman, Eric P (1); Karlsson, Magnus (1); Granjon, Laurent (1); Vandenput, Liesbeth, ... (1); Lorentzon, Mattias, ... (1); Abrahamczyk, Stefan (1); Jonsell, Mats (1); Raitakari, Olli T (1); Brunet, Jörg (1); Kolb, Annette (1); Soranzo, Nicole (1); Ohlsson, Claes, 1965 (1); Strachan, David P (1); Sáfián, Szabolcs (1); Persson, Anna S. (1); Franzén, Markus (1); Jung, Martin (1); Nilsson, Sven G (1); Stancáková, Alena (1); Kuusisto, Johanna (1); Laakso, Markku (1); Kilpeläinen, Tuomas ... (1); Eriksson, Joel (1); Ridker, Paul M. (1); Chasman, Daniel I. (1); Rose, Lynda M (1); Langenberg, Claudia (1); Paré, Guillaume (1); Hamsten, Anders (1); Scott, Robert A (1); Ingelsson, Erik (1); Shah, Nabi (1); Berg, Åke (1); Havulinna, Aki S. (1); Enroth, Stefan, 1976 ... (1); Johansson, Åsa (1); visa färre...

Lärosäte: Stockholms universitet (2); Göteborgs universitet (1); Umeå universitet (1); Uppsala universitet (1); Lunds universitet (1); Linnéuniversitetet (1); visa fler...; Karolinska Institutet (1); Sveriges Lantbruksuniversitet (1); visa färre...

Språk: Engelska (3)

Forskningsämne (UKÄ/SCB): Medicin och hälsovetenskap (2); Naturvetenskap (1)

År: 2017 (3)Ta bort avgränsningen

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