Search: WFRF:(Ording Anne Gulbech)
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Impact of comorbidi...
Impact of comorbidity on risk of venous thromboembolism in patients with breast cancer : a Danish population-based cohort study
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- Ording, Anne Gulbech (author)
- Aarhus Univ Hosp, Dept Clin Epidemiol, DK-8000 Aarhus, Denmark.
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- Horvath-Puho, Erzsebet (author)
- Aarhus Univ Hosp, Dept Clin Epidemiol, DK-8000 Aarhus, Denmark.
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- Garne, Jens Peter (author)
- Aalborg Univ Hosp, Breast Clin, Aalborg, Denmark.
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- Nyström, Petra Witt (author)
- Univ Uppsala Hosp, Dept Oncol, S-75185 Uppsala, Sweden.
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- Vyberg, Mogens (author)
- Aalborg Univ Hosp, Inst Pathol, Aalborg, Denmark.
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- Sorensen, Henrik Toft (author)
- Aarhus Univ Hosp, Dept Clin Epidemiol, DK-8000 Aarhus, Denmark.
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- Lash, Timothy L. (author)
- Aarhus Univ Hosp, Dept Clin Epidemiol, DK-8000 Aarhus, Denmark.;Emory Univ, Rollins Sch Publ Hlth, Dept Epidemiol, Atlanta, GA 30322 USA.
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Aarhus Univ Hosp, Dept Clin Epidemiol, DK-8000 Aarhus, Denmark Aalborg Univ Hosp, Breast Clin, Aalborg, Denmark. (creator_code:org_t)
- 2014-06-05
- 2014
- English.
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In: BMJ Open. - : BMJ. - 2044-6055. ; 4:6
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Abstract
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- Objectives: To assess the interaction between comorbidity and breast cancer (BC) on the rate of venous thromboembolism (VTE) beyond what can be explained by the independent effects of BC and comorbidity. Design: Population-based matched cohort study. Setting: Denmark. Participants: Danish patients with BC (n=62 376) diagnosed in 1995-2010 and a comparison cohort of women without BC (n=304 803) from the general population were matched to the patients with BC on year of birth in 5-year intervals and on the specific diseases included in the Charlson Comorbidity Index (CCI) and atrial fibrillation and obesity. Measures: The rate ratios of VTE per 1000 person-years (PY) were computed by comorbidity levels using the CCI, and interaction contrasts (IC) were calculated as a measure of the excess or deficit VTE rate not explained by the independent effects of BC and comorbidity. Results: Among patients with BC with a CCI score of 1, the 0-1 year VTE rate was 12/1000 PY, and interaction accounted for 10% of the rate (IC=3.2, 95% CI 0.5 to 5.9). Among patients with BC with CCI >= 4, the VTE rate was 17, and interaction accounted for 8% of the rate (IC=1.2, 95% CI -1.8 to 4.2). There was no interaction during 2-5 years of follow-up. Conclusions: There was only little interaction between BC and the CCI score on the rate of VTE.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
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- ref (subject category)
- art (subject category)
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