↓ Direkt till sidans innehåll
↓ Direkt till sidans sekundära innehåll (sidomenyn)

Träfflista för sökning "WFRF:(Ostman J) srt2:(2020)"

Search: WFRF:(Ostman J) > (2020)

Result 1-3 of 3

Sort/group result

Sort by: Hits per page:

Enumeration	Reference	Cover	Find
1.	Cheteh, EH, et al. (author) Interleukin-6 derived from cancer-associated fibroblasts attenuates the p53 response to doxorubicin in prostate cancer cells 2020 In: Cell death discovery. - : Springer Science and Business Media LLC. - 2058-7716. ; 6:1, s. 42- Journal article (peer-reviewed)abstract Cancer-associated fibroblasts (CAFs) promote tumor growth and progression, and increase drug resistance through several mechanisms. We have investigated the effect of CAFs on the p53 response to doxorubicin in prostate cancer cells. We show that CAFs produce interleukin-6 (IL-6), and that IL-6 attenuates p53 induction and upregulation of the pro-apoptotic p53 target Bax upon treatment with doxorubicin. This is associated with increased levels of MDM2 mRNA, Mdm2 protein bound to p53, and ubiquitinated p53. IL-6 also inhibited doxorubicin-induced cell death. Inhibition of JAK or STAT3 alleviated this effect, indicating that IL-6 attenuates p53 via the JAK/STAT signaling pathway. These results suggest that CAF-derived IL-6 plays an important role in protecting cancer cells from chemotherapy and that inhibition of IL-6 could have significant therapeutic value.
2.	Rundqvist, H, et al. (author) Cytotoxic T-cells mediate exercise-induced reductions in tumor growth 2020 In: eLife. - 2050-084X. ; 9 Journal article (peer-reviewed)
3.	Strell, C, et al. (author) High stromal platelet derived growth factor receptor beta predicts absence of benefit of radiotherapy after breast conserving surgery in breast ductal carcinoma in situ within the SweDCIS randomized trial 2020 In: CANCER RESEARCH. - 0008-5472. ; 80:4 Conference paper (other academic/artistic)

Skapa referenser, mejla, bekava och länka

Permalink

Result 1-3 of 3

Refine your search

Type of publication: journal article (2); conference paper (1)

Type of content: peer-reviewed (2); other academic/artistic (1)

Author/Editor: Ostman, A (3); Rundqvist, H (2); Bergh, J (1); Egevad, L (1); Holmberg, E. (1); Akslen, LA (1); show more...; Warnberg, F (1); Karlsson, P (1); Johnson, RS (1); Mijwel, S (1); Reitzner, SM (1); WIMAN, KG (1); Augsten, M (1); Strell, C (1); Bianchi, J (1); Barbieri, L (1); Velica, P (1); Gameiro, PA (1); Bargiela, D (1); Gojkovic, M (1); Ceder, S (1); Bremer, T. (1); Cheteh, EH (1); Sarne, V (1); Ule, J (1); Wulliman, D (1); Ahlstedt, E (1); Folkvaljon, D (1); show less...

University: Karolinska Institutet (3)

Language: English (3)

Year: 2020 (3)Undo refine

Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.

Copyright © LIBRIS - National Library Systems
LIBRIS.kb.se

pil uppåt

Close

Copy and save the link in order to return to this view