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Serum aromatic and ...
Serum aromatic and branched-chain amino acids associated with NASH demonstrate divergent associations with serum lipids
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- de Mello, Vanessa D. (författare)
- University of Eastern Finland
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- Sehgal, Ratika (författare)
- University of Eastern Finland
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- Männistö, Ville (författare)
- University of Eastern Finland
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- Klåvus, Anton (författare)
- University of Eastern Finland
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- Nilsson, Emma A (författare)
- Lund University,Lunds universitet,Diabetes - epigenetik,Forskargrupper vid Lunds universitet,Diabetes - Epigenetics,Lund University Research Groups
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- Perfilyev, Alexander (författare)
- Lund University,Lunds universitet,Diabetes - epigenetik,Forskargrupper vid Lunds universitet,Diabetes - Epigenetics,Lund University Research Groups
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- Kaminska, Dorota (författare)
- University of Eastern Finland
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- Miao, Zong (författare)
- University of California, Los Angeles
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- Pajukanta, Päivi (författare)
- University of California, Los Angeles
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- Ling, Charlotte (författare)
- Lund University,Lunds universitet,Diabetes - epigenetik,Forskargrupper vid Lunds universitet,Diabetes - Epigenetics,Lund University Research Groups
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- Hanhineva, Kati (författare)
- University of Turku,University of Eastern Finland
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- Pihlajamäki, Jussi (författare)
- Kuopio University Hospital,University of Eastern Finland
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(creator_code:org_t)
- 2020-12-05
- 2021
- Engelska.
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Ingår i: Liver International. - : Wiley. - 1478-3223 .- 1478-3231. ; 41:4, s. 754-763
- Relaterad länk:
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http://dx.doi.org/10... (free)
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https://onlinelibrar...
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https://lup.lub.lu.s...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- Background & Aims: Non-alcoholic fatty liver disease (NAFLD) has been associated with multiple metabolic abnormalities. By applying a non-targeted metabolomics approach, we aimed at investigating whether serum metabolite profile that associates with NAFLD would differ in its association with NAFLD-related metabolic risk factors. Methods & Results: A total of 233 subjects (mean ± SD: 48.3 ± 9.3 years old; BMI: 43.1 ± 5.4 kg/m2; 64 male) undergoing bariatric surgery were studied. Of these participants, 164 with liver histology could be classified as normal liver (n = 79), simple steatosis (SS, n = 40) or non-alcoholic steatohepatitis (NASH, n = 45). Among the identified fasting serum metabolites with higher levels in those with NASH when compared to those with normal phenotype were the aromatic amino acids (AAAs: tryptophan, tyrosine and phenylalanine), the branched-chain amino acids (BCAAs: leucine and isoleucine), a phosphatidylcholine (PC(16:0/16:1)) and uridine (all FDRp < 0.05). Only tryptophan was significantly higher in those with NASH compared to those with SS (FDRp < 0.05). Only the AAAs tryptophan and tyrosine correlated positively with serum total and LDL cholesterol (FDRp < 0.1), and accordingly, with liver LDLR at mRNA expression level. In addition, tryptophan was the single AA associated with liver DNA methylation of CpG sites known to be differentially methylated in those with NASH. Conclusions: We found that serum levels of the NASH-related AAAs and BCAAs demonstrate divergent associations with serum lipids. The specific correlation of tryptophan with LDL-c may result from the molecular events affecting LDLR mRNA expression and NASH-associated methylation of genes in the liver.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Endokrinologi och diabetes (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Endocrinology and Diabetes (hsv//eng)
Nyckelord
- aromatic amino acids
- DNA methylation
- epigenetics
- LDL cholesterol
- NAFLD
- NASH
- non-targeted metabolomics
- tryptophan
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de Mello, Vaness ...
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Sehgal, Ratika
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Männistö, Ville
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Klåvus, Anton
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Nilsson, Emma A
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Perfilyev, Alexa ...
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visa fler...
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Kaminska, Dorota
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Miao, Zong
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Pajukanta, Päivi
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Ling, Charlotte
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Hanhineva, Kati
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Pihlajamäki, Jus ...
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visa färre...
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