Sökning: WFRF:(Persson Jan)
> (1980-1984) >
Adenosine mechanism...
Adenosine mechanisms in the regulation of breathing in the rat.
-
- Wessberg, Per, 1954 (författare)
- Gothenburg University,Göteborgs universitet,Farmakologiska institutionen,Department of Pharmacology
-
- Hedner, Jan A, 1953 (författare)
- Gothenburg University,Göteborgs universitet,Farmakologiska institutionen,Department of Pharmacology
-
- Hedner, Thomas, 1949 (författare)
- Gothenburg University,Göteborgs universitet,Farmakologiska institutionen,Department of Pharmacology
-
visa fler...
-
- Persson, Bengt, 1949 (författare)
- Gothenburg University,Göteborgs universitet,Medicinska institutionen,Department medicine
-
- Jonason, Jan (författare)
- Gothenburg University,Göteborgs universitet,Farmakologiska institutionen,Department of Pharmacology
-
visa färre...
-
(creator_code:org_t)
- 1984
- 1984
- Engelska.
-
Ingår i: European journal of pharmacology. - 0014-2999. ; 106:1, s. 59-67
- Relaterad länk:
-
https://gup.ub.gu.se...
Abstract
Ämnesord
Stäng
- The central respiratory effects of various adenosine (A) analogues were studied in halothane-anesthetized rats. Intracerebroventricular (i.c.v.) and intraperitoneal (i.p.) injections of the A analogues (2-Cla, L-PIA, CHA and NECA) reduced minute ventilation (VE) due to decreases in respiratory frequency (f) as well as tidal volume (VT). Dose-dependent effects were seen after i.c.v. L-PIA in both normal and vagotomized rats. Analysis of the A-induced changes using the occluded breath technique revealed an increase in expiratory time (TE) as well as a decrease in inspiratory drive. NECA, a relatively specific A2 agonist seemed to be somewhat more potent in eliciting respiratory depression than a relatively specific A1 agonist like L-PIA. Pretreatment with the methylxanthine theophylline completely antagonized the respiratory depression induced by L-PIA. It is concluded that central A receptors are involved in the central regulation of breathing and that A interacts with the respiratory control system mainly by decreasing inspiratory neural drive and prolonging expiratory time.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Farmakologi och toxikologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Pharmacology and Toxicology (hsv//eng)
Nyckelord
- Adenosine
- analogs & derivatives
- pharmacology
- Animals
- Blood Gas Analysis
- Blood Pressure
- drug effects
- Carbon Dioxide
- pharmacology
- Dose-Response Relationship
- Drug
- Heart Rate
- drug effects
- Male
- Phenylisopropyladenosine
- pharmacology
- Rats
- Rats
- Inbred Strains
- Receptors
- Cell Surface
- drug effects
- Receptors
- Purinergic
- Respiration
- drug effects
- Respiratory Function Tests
- Stereoisomerism
- Theophylline
- pharmacology
- Xanthines
- pharmacology
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
Hitta via bibliotek
Till lärosätets databas