| 1. |
- Ernfors, P, et al.
(författare)
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Developmental and regional expression of beta-nerve growth factor receptor mRNA in the chick and rat.
- 1988
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Ingår i: Neuron. - 0896-6273 .- 1097-4199. ; 1:10, s. 983-96
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Tidskriftsartikel (refereegranskat)abstract
- Hybridization probes from the transmembrane region of the chick NGF receptor (NGF-R) that show high homology with the rat NGF-R were used to demonstrate an abundant 4.5 kb NGF-R mRNA in the chick embryo at E3.5. The level remained high until E12 but decreased to adult levels by E18. The highest levels at E8 were in spinal cord, bursa of Fabricius, gizzard, femoralis muscle, and skin. In situ hybridization to E7 embryos showed high expression of the NGF-R gene in spinal cord, particularly the lateral motor column, and in dorsal root, sympathetic, and nodose ganglia. NGF-R mRNA expression was observed throughout brain development and in all regions of the adult brain, with high levels in cerebellum and septum. Lymphoid tissues of chick and rat also expressed the receptor. The complex and widespread expression of NGF-R mRNA in areas not known to be NGF targets suggests broader functions for NGF.
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| 2. |
- Bengmark, S., et al.
(författare)
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NEUESTER STAND DER LEBERCHIRURGIE
- 1982
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Ingår i: Zentralblatt fur Chirurgie. - 0044-409X. ; 107:12, s. 689-696
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Tidskriftsartikel (refereegranskat)
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| 3. |
- Bolmsjo, M., et al.
(författare)
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Experimental set-up for studies of microwave-induced hyperthermia in rats
- 1982
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Ingår i: Physics in Medicine and Biology. - : IOP Publishing. - 0031-9155 .- 1361-6560. ; 27:3, s. 397-406
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Tidskriftsartikel (refereegranskat)abstract
- A low-cost microprocessor-based temperature controller for hyperthermia experiments on rats is described. The system directs a microwave generator, used for heating, by feedback power regulating signals in accordance with the temperature in the animal. The microwave power is pulsed for short on-and-off periods and the temperature recordings are carried out during the off periods. More than 300 hyperthermia runs have been carried out on rats using this fully automated unit. The controller can direct the hyperthermia to the predetermined level with a deviation of +or-0.1 degrees C for systemic hyperthermia. For local hyperthermia in the liver, individual recorded mean temperatures were up to -0.5 degrees C from the preset temperature.
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| 4. |
- Bolmsjo, M. S., et al.
(författare)
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A new instrument for survey monitoring of airborne xenon-133
- 1982
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Ingår i: Physics in Medicine and Biology. - : IOP Publishing. - 0031-9155 .- 1361-6560. ; 27:6, s. 861-866
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Tidskriftsartikel (refereegranskat)abstract
- Methods are reviewed for measuring xenon-133 contamination of the air in medical clinics. The principles of a new, simple, and low cost monitor are outlined. Results from experimental tests in laboratories and medical clinics were encouraging, indicating that the monitor is a valuable tool for survey measurements of 133Xe contamination in nuclear medicine departments.
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| 5. |
- Bolmsjö, M., et al.
(författare)
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Measurement of blood flow in rat liver with Xenon-133.
- 1983
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Ingår i: International journal of microcirculation, clinical and experimental / sponsored by the European Society for Microcirculation. - 0167-6865. ; 2:1, s. 27-37
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Tidskriftsartikel (refereegranskat)abstract
- The blood flow in rat liver was measured with Xe-133. Three techniques for administering the activity to the liver were employed: injection via the portal vein, via the hepatic artery, and directly into the liver parenchyma. Use of intraparenchymal injection of Xe-133 gave 60% higher flow values than by portal or arterial injection techniques. Mean flow index (k1) was for portal injection 0.52, for arterial injection 0.51 and for intraparenchymal injection 0.80. These variations may be explained by the microcirculatory anatomy of the rat liver. The data presented have a high degree of variance between repeated experiments on the same animal. During an experimental procedure, only larger changes in the liver blood flow pattern can be detected with sufficient accuracy. For this purpose, the method is applicable since repeated and regional studies on the same organ can easily be performed.
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| 6. |
- Bolmsjö, M. S., et al.
(författare)
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Factors affecting the trapping performance of xenon holdup-filters in nuclear medicine applications
- 1982
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Ingår i: Medical Physics. - : Wiley. - 0094-2405. ; 9:1, s. 96-105
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Tidskriftsartikel (refereegranskat)abstract
- Activated charcoal traps are used in nuclear medicine departments to capture exhaled radioactive xenon gas. In the present study, the trapping performance of charcoal was investigated for different physical qualities in experimental and clinical situations. Various factors affecting the trapping capacity are identified, such as the charcoal mass, moisture and carbon�dioxide concentrations in the sweep gas, gas�flow rate through the trap, and temperature. Improper drying of the exhaled air prior to passage through the charcoal bed appears to be a critical factor, leading to a much earlier breakthrough of xenon. Commercial xenon traps intended for ambient temperature operation were found to be useful only for a limited number of patients due to an early breakthrough point. By refrigerating the trap, however, a much larger capacity was achieved. If correctly managed, xenon traps constitute a useful alternative for isolating radioactive xenon wastes in clinical and experimental applications.
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| 7. |
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| 8. |
- Englund, E., et al.
(författare)
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Tumours of the central nervous system. Proton magnetic resonance relaxation times T1 and T2 and histopathologic correlates
- 1986
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Ingår i: Acta Radiologica Diagnosis. - : SAGE Publications. - 0567-8056. ; 27:6, s. 653-659
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Tidskriftsartikel (refereegranskat)abstract
- Proton MR relaxation times T1 and T2 were determined in vitro in 136 small specimens of astrocytomas grades I-IV, of oligodendrogliomas, metastases of adenocarcinomas, meningiomas and acoustic neuromas. In addition, 7 samples of peritumoural white matter were analysed. The analysed specimens were studied microscopically in their entirety regarding tumour type and occurrence of necrosis and non-tumour tissue admixture, such as fibrosis and haemorrhage. Most of the gliomas had longer relaxation times than normal white matter and T2 was significantly longer than in the other three tumour groups. The metastases had longer T1 than normal white matter, while T2 varied. The astrocytomas tended to show shorter relaxation times with increasing degree of malignancy, and shortening of T1 and T2 correlating with the proportion of tissue necrosis. Similarly, the metastases with tissue necrosis had shorter T1 and T2 than non-necrotic samples. The meningiomas had T1 values comparable with normal cortex, while the T2 values varied. Tumours containing a large proportion of fibrous tissue had shorter relaxation times than the others. Acoustic neuromas had only slightly longer T1 than normal white matter, while T2 was not prolonged. Both T1 and T2 were significantly shorter than in all other tumours studied. Peritumoural white matter had prolonged relaxation times compared with normal white matter, correlating to increased water content. These in vitro differences regarding relaxation times in various types of tumours of the central nervous system, dependent on various types of tissue alterations, should be of interest for the interpretation of in vivo images.
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| 9. |
- Györffy-Wagner, Z., et al.
(författare)
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Proton magnetic resonance relaxation times T1 and T2 related to postmortem interval : An Investigation on Porcine Brain Tissue
- 1986
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Ingår i: Acta Radiologica. - : SAGE Publications. - 0284-1851 .- 0567-8056. ; 27:1, s. 115-118
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Forskningsöversikt (refereegranskat)abstract
- In order to establish the validity of in vitro determination of the proton magnetic resonance (MR) relaxation times T1 and T2 in brain tissue at increasing time delay after death or operative excision, 81 brain tissue samples from 23 pigs were analyzed repeatedly. These samples, representing cortex, caudate nucleus and white matter, were studied microscopically after MR measurements. The T1 values exhibited no time dependence and the T2 values decreased slightly during the interval 2 to 90 hours after death. The samples were stored at +8°C between the measurements. These results indicate that reliable in vitro measurements can be obtained in autopsy or surgical brain tissue specimens within 90 hours after death or excision, if handled properly.
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| 10. |
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