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Role of ghrelin pol...
Role of ghrelin polymorphisms in obesity based on three different studies.
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Ukkola, Olavi (författare)
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Ravussin, Eric (författare)
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- Jacobson, Peter, 1962 (författare)
- Gothenburg University,Göteborgs universitet,Institutionen för invärtesmedicin,Institute of Internal Medicine
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Pérusse, Louis (författare)
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Rankinen, Tuomo (författare)
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Tschöp, Matthias (författare)
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Heiman, Mark L (författare)
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Leon, Arthur S (författare)
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Rao, D C (författare)
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Skinner, James S (författare)
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Wilmore, Jack H (författare)
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- Sjöström, Lars (författare)
- Gothenburg University,Göteborgs universitet,Institutionen för invärtesmedicin,Institutionen för invärtesmedicin, Avdelningen för kroppssammansättning och metabolism,Institute of Internal Medicine,Institute of Internal Medicine, Dept of Body Composition and Metabolism
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Bouchard, Claude (författare)
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(creator_code:org_t)
- 2012-09-06
- 2002
- Engelska.
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Ingår i: Obesity research. - : Wiley. - 1071-7323. ; 10:8, s. 782-91
- Relaterad länk:
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https://onlinelibrar...
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https://gup.ub.gu.se...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- OBJECTIVE: Associations between preproghrelin DNA variants and obesity-related phenotypes were studied in 3004 subjects from the Québec Family Study (QFS), the HERITAGE Family Study (HERITAGE), and the Swedish Obese Subjects (SOS) Study. RESEARCH METHODS AND PROCEDURES: Body mass index (BMI), fat mass (FM) from underwater weighing, and abdominal fat from computerized tomography were measured. The ghrelin polymorphisms were identified by polymerase chain reaction. RESULTS: Arg51Gln QFS subjects (n = 6) had lower ghrelin concentrations (p = 0.007) than Arg51Arg subjects (n = 14). White preproghrelin Met72Met subjects in HERITAGE had the lowest BMI (p = 0.020), and those in the QFS cohort had the lowest FM (p < 0.001). Met72 carrier status (Met72+) was associated with lower FM (p = 0.026) and higher insulin-like growth factor-1 levels (p = 0.019) among blacks. Met72Met QFS subjects had less visceral fat (p = 0.002) and a lower fasting respiratory quotient (p = 0.037). HERITAGE Met72+ white subjects also showed lower exercise respiratory quotient (p = 0.030) and higher maximal oxygen uptake (p = 0.023). Furthermore, the prevalence of Met72+ was higher (19.2%; p < 0.05) in SOS subjects whose BMI was < or =25 kg/m(2) than in those with BMI >25 kg/m(2) (14.8%). SOS Met72+ obese women had a lower (11.4%; p = 0.032) prevalence of hypertension than noncarriers (23.9%). DISCUSSION: Arg51Gln mutation was associated with lower plasma ghrelin levels but not with obesity. The preproghrelin Met72 carrier status seems to be protective against fat accumulation and associated metabolic comorbidities.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Medicinsk genetik (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Medical Genetics (hsv//eng)
Nyckelord
- Abdomen
- Adipose Tissue
- Alleles
- Body Composition
- Body Mass Index
- Exercise
- Female
- Genotype
- Ghrelin
- Humans
- Hypertension
- complications
- genetics
- Male
- Mutation
- Obesity
- complications
- genetics
- Oxygen Consumption
- Peptide Hormones
- blood
- genetics
- Phenotype
- Polymerase Chain Reaction
- Polymorphism
- Genetic
- Quebec
- Sweden
- Tomography
- X-Ray Computed
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
Hitta via bibliotek
Till lärosätets databas
- Av författaren/redakt...
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Ukkola, Olavi
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Ravussin, Eric
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Jacobson, Peter, ...
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Pérusse, Louis
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Rankinen, Tuomo
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Tschöp, Matthias
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visa fler...
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Heiman, Mark L
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Leon, Arthur S
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Rao, D C
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Skinner, James S
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Wilmore, Jack H
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Sjöström, Lars
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Bouchard, Claude
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visa färre...
- Om ämnet
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Medicinska och f ...
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och Medicinsk geneti ...
- Artiklar i publikationen
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Obesity research
- Av lärosätet
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Göteborgs universitet