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Cost-utility of bio...
Cost-utility of biological treatment sequences for luminal Crohn's disease in Europe
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- Rencz, Fanni (author)
- Department of Health Economics, Corvinus University of Budapest, Budapest, Hungary
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- Gulácsi, László (author)
- Department of Health Economics, Corvinus University of Budapest, Budapest, Hungary
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- Péntek, Márta (author)
- Department of Health Economics, Corvinus University of Budapest, Budapest, Hungary
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- Gecse, Krisztina B. (author)
- 1st Department of Medicine, Semmelweis University, Budapest, Hungary
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- Dignass, Axel (author)
- Department of Medicine 1, Agaplesion Markus Krankenhaus, Frankfurt, Germany
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- Halfvarson, Jonas, 1970- (author)
- Örebro universitet,Institutionen för medicinska vetenskaper,Department of Gastroenterology, Faculty of Health and Medical Sciences, Örebro University, Örebro, Sweden
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- Gomollón, Fernando (author)
- Gastroenterology Unit, Clinical Universitary Hospital Lozano IIS Aragón (Blesa, IIS Aragón, CIBEREHD), Zaragoza, Spain
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- Baji, Petra (author)
- Department of Health Economics, Corvinus University of Budapest, Budapest, Hungary; Center for Economic Research and Graduate Education (CERGE) Economics Institute (EI) Research Fellow, Charles University, Praha, The Czech Republic
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- Peyrin-Biroulet, Laurent (author)
- Inserm U954 and Department of Hepato-Gastroenterology, University Hospital of Nancy-Brabois, Lorraine University, Vandoeuvre-lès-Nancy, France
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- Lakatos, Peter L. (author)
- 1st Department of Medicine, Semmelweis University, Budapest, Hungary
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- Brodszky, Valentin (author)
- Department of Health Economics, Corvinus University of Budapest, Budapest, Hungary
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(creator_code:org_t)
- 2017-04-28
- 2017
- English.
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In: Expert review of pharmacoeconomics & outcomes research. - : Taylor & Francis. - 1473-7167 .- 1744-8379. ; 17:6, s. 597-606
- Related links:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
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- BACKGROUND: This study aims to compare the cost-effectiveness of treatment sequences with available biologics, including adalimumab (ADA), biosimilar infliximab (bsIFX), originator infliximab (IFX) and vedolizumab (VEDO) for luminal Crohn's disease in nine European countries.METHODS: A Markov-model was constructed to simulate five-year medical costs and quality-adjusted life years (QALYs). Data on clinical efficacy were obtained from randomised controlled trials. Country-specific unit costs, discount rates and a third-party payer perspective were applied.RESULTS: The bsIFX versus conventional therapy resulted in the most favourable incremental cost-utility ratios (ICURs) ranging from €34,580 (Hungary) to €77,062/QALY (Sweden). Compared to bsIFX, the bsIFX-ADA sequence was more cost-effective than the bsIFX-VEDO sequence with ICURs varying between €70,277 (France) and €162,069/QALY (Germany). The ICURs of the bsIFX-ADA-VEDO sequence versus the bsIFX-ADA strategy were between €206,266 (The Netherlands) and €363,232/QALY (Spain).CONCLUSION: We are the first to compare cost-effectiveness of multiple biological sequences for luminal Crohn's disease. Based on our findings, bsIFX can be recommended as a first-line treatment in patients unresponsive to conventional treatments. While biological sequences only slightly differ in their associated health gains, their costs vary greatly. The bsIFX-ADA-VEDO seems to be the most cost-effective sequence of the available biologics across Europe.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Hälsovetenskap -- Hälso- och sjukvårdsorganisation, hälsopolitik och hälsoekonomi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Health Sciences -- Health Care Service and Management, Health Policy and Services and Health Economy (hsv//eng)
Keyword
- Adalimumab
- biosimilar infliximab
- cost-effectiveness
- Crohn's disease
- inflammatory bowel diseases; infliximab
- vedolizumab
Publication and Content Type
- ref (subject category)
- art (subject category)
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Rencz, Fanni
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Gulácsi, László
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Péntek, Márta
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Gecse, Krisztina ...
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Dignass, Axel
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Halfvarson, Jona ...
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Gomollón, Fernan ...
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Baji, Petra
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Peyrin-Biroulet, ...
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Lakatos, Peter L ...
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Brodszky, Valent ...
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Örebro University