Gene structure of semenogelin I and II. The predominant proteins in human semen are encoded by two homologous genes on chromosome 20

• The genes for semenogelin I and II, the major protein constituents of the human seminal fluid, have been characterized by three overlapping clones in bacteriophage lambda, encompassing 31.5 kilobases (kb) of genomic DNA. The two genes are located 11.5 kb apart in the region q12-q13.1 on chromosome 20. Both genes are relatively compact, spanning only 2.7 and 3.1 kb, respectively. The transcription units are composed of three exons, of which the first encodes the signal peptide, the second encodes the secreted protein, while the third solely contains 3'-noncoding nucleotides. The nucleotide sequences exhibit a similarity of close to 90% in the exons and exceeding 80% in the introns and flanking nucleotides.

Ämnesord

MEDICIN OCH HÄLSOVETENSKAP  -- Medicinska och farmaceutiska grundvetenskaper -- Läkemedelskemi (hsv//swe)

MEDICAL AND HEALTH SCIENCES  -- Basic Medicine -- Medicinal Chemistry (hsv//eng)

Nyckelord

Molecular Sequence Data

Male

Humans

Gonadal Steroid Hormones/*genetics

DNA/genetics/isolation & purification

Codon/genetics

Molecular

Cloning

Pair 20

Human

*Chromosomes

Chromosome Mapping

Chromosome Banding

Southern

Blotting

Amino Acid Sequence

Base Sequence

*Multigene Family

Oligodeoxyribonucleotides

Research Support

Non-U.S. Gov't

Restriction Mapping

Semen/*physiology

*Seminal Vesicle Secretory Proteins

Spermatozoa/*physiology

Publikations- och innehållstyp

art (ämneskategori)

ref (ämneskategori)