SwePub
Sök i SwePub databas

  Utökad sökning

Träfflista för sökning "WFRF:(Riboli E.) ;srt2:(2015-2019)"

Sökning: WFRF:(Riboli E.) > (2015-2019)

  • Resultat 51-60 av 120
Sortera/gruppera träfflistan
   
NumreringReferensOmslagsbildHitta
51.
  •  
52.
  •  
53.
  •  
54.
  •  
55.
  •  
56.
  •  
57.
  • Watts, Eleanor L., et al. (författare)
  • Circulating sex hormones in relation to anthropometric, sociodemographic and behavioural factors in an international dataset of 12,300 men
  • 2017
  • Ingår i: PLOS ONE. - : Public Library of Science (PLoS). - 1932-6203. ; 12:12
  • Tidskriftsartikel (refereegranskat)abstract
    • Introduction: Sex hormones have been implicated in the etiology of a number of diseases. To better understand disease etiology and the mechanisms of disease-risk factor associations, this analysis aimed to investigate the associations of anthropometric, sociodemographic and behavioural factors with a range of circulating sex hormones and sex hormone-binding globulin.Methods: Statistical analyses of individual participant data from 12,330 male controls aged 25–85 years from 25 studies involved in the Endogenous Hormones Nutritional Biomarkers and Prostate Cancer Collaborative Group. Analysis of variance was used to estimate geometric means adjusted for study and relevant covariates.Results: Older age was associated with higher concentrations of sex hormone-binding globulin and dihydrotestosterone and lower concentrations of dehydroepiandrosterone sulfate, free testosterone, androstenedione, androstanediol glucuronide and free estradiol. Higher body mass index was associated with higher concentrations of free estradiol, androstanediol glucuronide, estradiol and estrone and lower concentrations of dihydrotestosterone, testosterone, sex hormone-binding globulin, free testosterone, androstenedione and dehydroepiandrosterone sulfate. Taller height was associated with lower concentrations of androstenedione, testosterone, free testosterone and sex hormone-binding globulin and higher concentrations of androstanediol glucuronide. Current smoking was associated with higher concentrations of androstenedione, sex hormone-binding globulin and testosterone. Alcohol consumption was associated with higher concentrations of dehydroepiandrosterone sulfate, androstenedione and androstanediol glucuronide. East Asians had lower concentrations of androstanediol glucuronide and African Americans had higher concentrations of estrogens. Education and marital status were modestly associated with a small number of hormones.Conclusion: Circulating sex hormones in men are strongly associated with age and body mass index, and to a lesser extent with smoking status and alcohol consumption.
  •  
58.
  • Zhang, Mingfeng, et al. (författare)
  • Three new pancreatic cancer susceptibility signals identified on chromosomes 1q32.1, 5p15.33 and 8q24.21
  • 2016
  • Ingår i: Oncotarget. - : Impact Journals, LLC. - 1949-2553. ; 7:41, s. 66328-66343
  • Tidskriftsartikel (refereegranskat)abstract
    • Genome-wide association studies (GWAS) have identified common pancreatic cancer susceptibility variants at 13 chromosomal loci in individuals of European descent. To identify new susceptibility variants, we performed imputation based on 1000 Genomes (1000G) Project data and association analysis using 5,107 case and 8,845 control subjects from 27 cohort and case-control studies that participated in the PanScan I-III GWAS. This analysis, in combination with a two-staged replication in an additional 6,076 case and 7,555 control subjects from the PANcreatic Disease ReseArch (PANDoRA) and Pancreatic Cancer Case-Control (PanC4) Consortia uncovered 3 new pancreatic cancer risk signals marked by single nucleotide polymorphisms (SNPs) rs2816938 at chromosome 1q32.1 (per allele odds ratio (OR) = 1.20, P = 4.88x10(-15)), rs10094872 at 8q24.21 (OR = 1.15, P = 3.22x10(-9)) and rs35226131 at 5p15.33 (OR = 0.71, P = 1.70x10(-8)). These SNPs represent independent risk variants at previously identified pancreatic cancer risk loci on chr1q32.1 (NR5A2), chr8q24.21 (MYC) and chr5p15.33 (CLPTM1L-TERT) as per analyses conditioned on previously reported susceptibility variants. We assessed expression of candidate genes at the three risk loci in histologically normal (n = 10) and tumor (n = 8) derived pancreatic tissue samples and observed a marked reduction of NR5A2 expression (chr1q32.1) in the tumors (fold change -7.6, P = 5.7x10(-8)). This finding was validated in a second set of paired (n = 20) histologically normal and tumor derived pancreatic tissue samples (average fold change for three NR5A2 isoforms -31.3 to -95.7, P = 7.5x10(-4)-2.0x10(-3)). Our study has identified new susceptibility variants independently conferring pancreatic cancer risk that merit functional follow-up to identify target genes and explain the underlying biology.
  •  
59.
  •  
60.
  • Bradbury, Kathryn E., et al. (författare)
  • Circulating insulin-like growth factor I in relation to melanoma risk in the European prospective investigation into cancer and nutrition
  • 2019
  • Ingår i: International Journal of Cancer. - : John Wiley & Sons. - 0020-7136 .- 1097-0215. ; 144:5, s. 957-966
  • Tidskriftsartikel (refereegranskat)abstract
    • Insulin-like growth factor-I (IGF-I) regulates cell proliferation and apoptosis, and is thought to play a role in tumour development. Previous prospective studies have shown that higher circulating concentrations of IGF-I are associated with a higher risk of cancers at specific sites, including breast and prostate. No prospective study has examined the association between circulating IGF-I concentrations and melanoma risk. A nested case-control study of 1,221 melanoma cases and 1,221 controls was performed in the European Prospective Investigation into Cancer and Nutrition cohort, a prospective cohort of 520,000 participants recruited from 10 European countries. Conditional logistic regression was used to estimate odds ratios (ORs) for incident melanoma in relation to circulating IGF-I concentrations, measured by immunoassay. Analyses were conditioned on the matching factors and further adjusted for age at blood collection, education, height, BMI, smoking status, alcohol intake, marital status, physical activity and in women only, use of menopausal hormone therapy. There was no significant association between circulating IGF-I concentration and melanoma risk (OR for highest vs lowest fifth = 0.93 [95% confidence interval [CI]: 0.71 to 1.22]). There was no significant heterogeneity in the association between IGF-I concentrations and melanoma risk when subdivided by gender, age at blood collection, BMI, height, age at diagnosis, time between blood collection and diagnosis, or by anatomical site or histological subtype of the tumour (Pheterogeneity≥0.078). We found no evidence for an association between circulating concentrations of IGF-I measured in adulthood and the risk of melanoma.
  •  
Skapa referenser, mejla, bekava och länka
  • Resultat 51-60 av 120
Typ av publikation
tidskriftsartikel (119)
forskningsöversikt (1)
Typ av innehåll
refereegranskat (116)
övrigt vetenskapligt/konstnärligt (4)
Författare/redaktör
Riboli, Elio (64)
Riboli, E. (55)
Overvad, Kim (43)
Boeing, Heiner (42)
Trichopoulou, Antoni ... (42)
Weiderpass, Elisabet ... (40)
visa fler...
Kaaks, Rudolf (36)
Tumino, Rosario (36)
Khaw, Kay-Tee (35)
Palli, Domenico (34)
Boeing, H. (31)
Panico, Salvatore (31)
Weiderpass, E (30)
Tjonneland, Anne (30)
Overvad, K (29)
Boutron-Ruault, Mari ... (29)
Kaaks, R. (27)
Tumino, R. (27)
Tjonneland, A (26)
Palli, D (26)
Peeters, Petra H (25)
Jenab, Mazda (21)
Giles, Graham G (19)
Dorronsoro, Miren (19)
Barricarte, Aurelio (18)
Vineis, Paolo (18)
Vineis, P (18)
Tjønneland, Anne (17)
Bueno-de-Mesquita, H ... (17)
Key, Timothy J (17)
Trichopoulos, D (17)
Ardanaz, Eva (17)
Sacerdote, Carlotta (16)
Ardanaz, E. (16)
Lagiou, Pagona (16)
Sánchez, Maria-José (15)
Wareham, Nick (15)
Gunter, Marc J. (15)
Cross, Amanda J. (15)
Wareham, Nicholas J. (15)
Brenner, H (14)
Skeie, Guri (14)
Khaw, K. T. (14)
Wolk, Alicja (14)
Travis, Ruth C (14)
Murphy, Neil (14)
Freisling, Heinz (14)
Grioni, Sara (14)
Trichopoulos, Dimitr ... (14)
Key, T (14)
visa färre...
Lärosäte
Umeå universitet (73)
Karolinska Institutet (56)
Lunds universitet (44)
Uppsala universitet (23)
Göteborgs universitet (9)
Luleå tekniska universitet (2)
visa fler...
Stockholms universitet (1)
Sveriges Lantbruksuniversitet (1)
visa färre...
Språk
Engelska (120)
Forskningsämne (UKÄ/SCB)
Medicin och hälsovetenskap (95)
Naturvetenskap (2)
Samhällsvetenskap (1)

År

Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.

 
pil uppåt Stäng

Kopiera och spara länken för att återkomma till aktuell vy