| 1. |
- Elsik, Christine G., et al.
(författare)
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The Genome Sequence of Taurine Cattle : A Window to Ruminant Biology and Evolution
- 2009
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Ingår i: Science. - : American Association for the Advancement of Science (AAAS). - 0036-8075 .- 1095-9203. ; 324:5926, s. 522-528
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Tidskriftsartikel (refereegranskat)abstract
- To understand the biology and evolution of ruminants, the cattle genome was sequenced to about sevenfold coverage. The cattle genome contains a minimum of 22,000 genes, with a core set of 14,345 orthologs shared among seven mammalian species of which 1217 are absent or undetected in noneutherian (marsupial or monotreme) genomes. Cattle-specific evolutionary breakpoint regions in chromosomes have a higher density of segmental duplications, enrichment of repetitive elements, and species-specific variations in genes associated with lactation and immune responsiveness. Genes involved in metabolism are generally highly conserved, although five metabolic genes are deleted or extensively diverged from their human orthologs. The cattle genome sequence thus provides a resource for understanding mammalian evolution and accelerating livestock genetic improvement for milk and meat production.
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| 2. |
- Clark, Andrew G., et al.
(författare)
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Evolution of genes and genomes on the Drosophila phylogeny
- 2007
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Ingår i: Nature. - : Springer Science and Business Media LLC. - 0028-0836 .- 1476-4687. ; 450:7167, s. 203-218
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Tidskriftsartikel (refereegranskat)abstract
- Comparative analysis of multiple genomes in a phylogenetic framework dramatically improves the precision and sensitivity of evolutionary inference, producing more robust results than single-genome analyses can provide. The genomes of 12 Drosophila species, ten of which are presented here for the first time (sechellia, simulans, yakuba, erecta, ananassae, persimilis, willistoni, mojavensis, virilis and grimshawi), illustrate how rates and patterns of sequence divergence across taxa can illuminate evolutionary processes on a genomic scale. These genome sequences augment the formidable genetic tools that have made Drosophila melanogaster a pre-eminent model for animal genetics, and will further catalyse fundamental research on mechanisms of development, cell biology, genetics, disease, neurobiology, behaviour, physiology and evolution. Despite remarkable similarities among these Drosophila species, we identified many putatively non-neutral changes in protein-coding genes, non-coding RNA genes, and cis-regulatory regions. These may prove to underlie differences in the ecology and behaviour of these diverse species.
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| 3. |
- Sodergren, Erica, et al.
(författare)
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The genome of the sea urchin Strongylocentrotus purpuratus.
- 2006
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Ingår i: Science. - : American Association for the Advancement of Science (AAAS). - 1095-9203 .- 0036-8075. ; 314:5801, s. 941-52
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Tidskriftsartikel (refereegranskat)abstract
- We report the sequence and analysis of the 814-megabase genome of the sea urchin Strongylocentrotus purpuratus, a model for developmental and systems biology. The sequencing strategy combined whole-genome shotgun and bacterial artificial chromosome (BAC) sequences. This use of BAC clones, aided by a pooling strategy, overcame difficulties associated with high heterozygosity of the genome. The genome encodes about 23,300 genes, including many previously thought to be vertebrate innovations or known only outside the deuterostomes. This echinoderm genome provides an evolutionary outgroup for the chordates and yields insights into the evolution of deuterostomes.
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| 4. |
- Asher, Lucy, et al.
(författare)
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An empirical investigation of two assumptions of motivation testing in captive starlings (Sturnus vulgaris) : Do animals have an energy budget to spend? and does cost reduce demand?
- 2009
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Ingår i: APPLIED ANIMAL BEHAVIOUR SCIENCE. - : Elsevier BV. - 0168-1591. ; 118:3-4, s. 152-160
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Tidskriftsartikel (refereegranskat)abstract
- The use of demand curves to derive estimates of motivational strength is a popular method for measuring animals preferences for a range of different resources in applied animal behaviour research. In a typical experiment, an animal pays a gradually increasing cost (e.g. by pushing through a weighted door) in order to access a resource it wants or needs. The resulting demand curves are used to calculate several measures of the strength of the animals motivation to access the resource. We tested two assumptions that underlie the majority of applications of this approach: first, that animals have a fixed energy budget to spend on access to resources: and second, that the effect of price on demand is not greatly influenced by the order or magnitude of the price changes. Sixteen European starlings (Sturnus vulgaris) were trained to push through weighted doors to gain access to one of two resources, either a tray of turf, or protective foliage cover. In the first stage of the experiment reservation prices were established for each bird by daily increasing the force necessary to open the door until the bird no longer accessed the resource. In the next stage, five different forces, chosen to evenly cover the range between free entry and each individual birds reservation price, were presented in a random order under two levels of food availability. Overall, price was the most important determinant of demand. However, birds demand for resources was increased by food rationing, suggesting that the cost of pushing the weighted doors might not have been energy. Birds willingness to pay for a resource was also dependent upon the order in which the forces were presented, and specifically the contrast from the force presented the previous day. The results support the continued use of presenting costs on an ascending order to measure the demand in captive animals, but suggest that random order presentations can be used to check for order effects. We also suggest that the concept of a finite energy budget that animals have to spend on resources may not be useful in the measurement of captive animals preferences and that a different approach might be needed.
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| 5. |
- Cooper, Stephen, et al.
(författare)
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An Exploration of the Current State of Information Assurance Education
- 2009
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Ingår i: ACM SIGCSE Bulletin. - : Association for Computing Machinery (ACM). - 0097-8418. ; 41:4, s. 109-125
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Tidskriftsartikel (refereegranskat)abstract
- Information Assurance and computer security are serious worldwide concerns of governments, industry, and academia. Computer security is one of the three new focal areas of the ACM/IEEE’s Computer Science Curriculum update in 2008. This ACM/IEEE report describes, as the first of its three recent trends, “the emergence of security as a major area of concern.” The importance of Information Assurance and Information Assurance education is not limited to the United States. Other nations, including the United Kingdom, Australia, New Zealand, Canada, and other members from NATO countries and the EU, have inquired as to how they may be able to establish Information Assurance education programs in their own country. The goal of this document is to explore the space of various existing Information Assurance educational standards and guidelines, and how they may serve as a basis for helping to define the field of Information Assurance. It was necessary for this working group to study what has been done for other areas of computing. For example, computer science (CS 2008 and associate-degree CS 2009), information technology (IT 2008), and software engineering (SE 2004), all have available curricular guidelines. In its exploration of existing government, industry, and academic Information Assurance guidelines and standards, as well as in its discovery of what guidance is being provided for other areas of computing, the working group has developed this paper as a foundation, or a starting point, for creating an appropriate set of guidelines for Information Assurance education. In researching the space of existing guidelines and standards, several challenges and opportunities to Information Assurance education were discovered. These are briefly described and discussed, and some next steps suggested.
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| 6. |
- Shete, Sanjay, et al.
(författare)
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Genome-wide association study identifies five susceptibility loci for glioma.
- 2009
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Ingår i: Nature Genetics. - : Springer Science and Business Media LLC. - 1061-4036 .- 1546-1718. ; 41:8, s. 899-904
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Tidskriftsartikel (refereegranskat)abstract
- To identify risk variants for glioma, we conducted a meta-analysis of two genome-wide association studies by genotyping 550K tagging SNPs in a total of 1,878 cases and 3,670 controls, with validation in three additional independent series totaling 2,545 cases and 2,953 controls. We identified five risk loci for glioma at 5p15.33 (rs2736100, TERT; P = 1.50 x 10(-17)), 8q24.21 (rs4295627, CCDC26; P = 2.34 x 10(-18)), 9p21.3 (rs4977756, CDKN2A-CDKN2B; P = 7.24 x 10(-15)), 20q13.33 (rs6010620, RTEL1; P = 2.52 x 10(-12)) and 11q23.3 (rs498872, PHLDB1; P = 1.07 x 10(-8)). These data show that common low-penetrance susceptibility alleles contribute to the risk of developing glioma and provide insight into disease causation of this primary brain tumor.
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