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Träfflista för sökning "WFRF:(Ripke Stephan) srt2:(2015)"

Sökning: WFRF:(Ripke Stephan) > (2015)

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Numrering	Referens	Omslagsbild	Hitta
1.	Locke, Adam E, et al. (författare) Genetic studies of body mass index yield new insights for obesity biology. 2015 Ingår i: Nature. - : Springer Science and Business Media LLC. - 0028-0836 .- 1476-4687. ; 518:7538, s. 197-401 Tidskriftsartikel (refereegranskat)abstract Obesity is heritable and predisposes to many diseases. To understand the genetic basis of obesity better, here we conduct a genome-wide association study and Metabochip meta-analysis of body mass index (BMI), a measure commonly used to define obesity and assess adiposity, in up to 339,224 individuals. This analysis identifies 97 BMI-associated loci (P < 5 × 10(-8)), 56 of which are novel. Five loci demonstrate clear evidence of several independent association signals, and many loci have significant effects on other metabolic phenotypes. The 97 loci account for ∼2.7% of BMI variation, and genome-wide estimates suggest that common variation accounts for >20% of BMI variation. Pathway analyses provide strong support for a role of the central nervous system in obesity susceptibility and implicate new genes and pathways, including those related to synaptic function, glutamate signalling, insulin secretion/action, energy metabolism, lipid biology and adipogenesis.
2.	Ek, Weronica E, et al. (författare) Exploring the genetics of irritable bowel syndrome: a GWA study in the general population and replication in multinational case-control cohorts. 2015 Ingår i: Gut. - : BMJ. - 1468-3288 .- 0017-5749. ; 64, s. 1774-1782 Tidskriftsartikel (refereegranskat)abstract IBS shows genetic predisposition, but adequately powered gene-hunting efforts have been scarce so far. We sought to identify true IBS genetic risk factors by means of genome-wide association (GWA) and independent replication studies.
3.	Goyette, Philippe, et al. (författare) High-density mapping of the MHC identifies a shared role for HLA-DRB101 : 03 in inflammatory bowel diseases and heterozygous advantage in ulcerative colitis 2015 Ingår i:* Nature Genetics. - New York, USA : Nature Publishing Group. - 1061-4036 .- 1546-1718. ; 47:2, s. 172-179 Tidskriftsartikel (refereegranskat)abstract Genome-wide association studies of the related chronic inflammatory bowel diseases (IBD) known as Crohn's disease and ulcerative colitis have shown strong evidence of association to the major histocompatibility complex (MHC). This region encodes a large number of immunological candidates, including the antigen-presenting classical human leukocyte antigen (HLA) molecules. Studies in IBD have indicated that multiple independent associations exist at HLA and non-HLA genes, but they have lacked the statistical power to define the architecture of association and causal alleles. To address this, we performed high-density SNP typing of the MHC in >32,000 individuals with IBD, implicating multiple HLA alleles, with a primary role for HLA-DRB1*01:03 in both Crohn's disease and ulcerative colitis. Noteworthy differences were observed between these diseases, including a predominant role for class II HLA variants and heterozygous advantage observed in ulcerative colitis, suggesting an important role of the adaptive immune response in the colonic environment in the pathogenesis of IBD.

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Resultat 1-3 av 3

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Typ av publikation: tidskriftsartikel (3)

Typ av innehåll: refereegranskat (3)

Författare/redaktör: Franks, Paul (1); Berne, Christian (1); Lyssenko, Valeriya (1); Groop, Leif (1); Vandenput, Liesbeth, ... (1); März, Winfried (1); visa fler...; Törnblom, Hans, 1966 (1); Salomaa, Veikko (1); Perola, Markus (1); Karlsen, Tom H (1); Chen, Jin (1); Lind, Lars (1); Simrén, Magnus, 1966 (1); Raitakari, Olli T (1); Kuh, Diana (1); Melbye, Mads (1); Halfvarson, Jonas, 1 ... (1); Haiman, Christopher ... (1); Schumacher, Fredrick ... (1); Berndt, Sonja I (1); Chanock, Stephen J (1); Grönberg, Henrik (1); Sattar, Naveed (1); Campbell, Harry (1); Rudan, Igor (1); Ohlsson, Claes, 1965 (1); Strachan, David P (1); Goodall, Alison H (1); Deloukas, Panos (1); Syvänen, Ann-Christi ... (1); Talley, Nicholas J. (1); Peters, Ulrike (1); Ohlsson, Bodil (1); Shungin, Dmitry (1); North, Kari E. (1); Agréus, Lars (1); Lindberg, Greger (1); Andreasson, Anna (1); Wareham, Nicholas J. (1); Hallmans, Göran (1); Clarke, Robert (1); Burwinkel, Barbara (1); Hall, Per (1); Zheng, Wei (1); Fall, Tove (1); Stancáková, Alena (1); Kuusisto, Johanna (1); Laakso, Markku (1); McCarthy, Mark I (1); Ferrannini, Ele (1); visa färre...

Lärosäte: Karolinska Institutet (3); Göteborgs universitet (2); Umeå universitet (2); Uppsala universitet (2); Lunds universitet (2); Stockholms universitet (1); visa fler...; Örebro universitet (1); Linköpings universitet (1); Högskolan Dalarna (1); visa färre...

Språk: Engelska (3)

Forskningsämne (UKÄ/SCB): Medicin och hälsovetenskap (2); Naturvetenskap (1)

År: 2015 (3)Ta bort avgränsningen

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