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| 2. |
- Bergman, Åke, et al.
(författare)
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A novel abbreviation standard for organobromine, organochlorine and organophosphorus flame retardants and some characteristics of the chemicals
- 2012
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Ingår i: Environment International. - : Elsevier BV. - 0160-4120 .- 1873-6750. ; 49, s. 57-82
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Forskningsöversikt (refereegranskat)abstract
- Ever since the interest in organic environmental contaminants first emerged 50 years ago, there has been a need to present discussion of such chemicals and their transformation products using simple abbreviations so as to avoid the repetitive use of long chemical names. As the number of chemicals of concern has increased, the number of abbreviations has also increased dramatically, sometimes resulting in the use of different abbreviations for the same chemical. In this article, we propose abbreviations for flame retardants (FRs) substituted with bromine or chlorine atoms or including a functional group containing phosphorus, i.e. BFRs, CFRs and PFRs, respectively. Due to the large number of halogenated and organophosphorus FRs, it has become increasingly important to develop a strategy for abbreviating the chemical names of FRs. In this paper, a two step procedure is proposed for deriving practical abbreviations (PRABs) for the chemicals discussed. In the first step, structural abbreviations (STABs) are developed using specific STAB criteria based on the FR structure. However, since several of the derived STABs are complicated and long, we propose instead the use of PRABs. These are, commonly, an extract of the most essential part of the STAB, while also considering abbreviations previously used in the literature. We indicate how these can be used to develop an abbreviation that can be generally accepted by scientists and other professionals involved in FR related work. Tables with PRABs and STABs for BFRs, CFRs and PERs are presented, including CAS (Chemical Abstract Service) numbers, notes of abbreviations that have been used previously, CA (Chemical Abstract) name, common names and trade names, as well as some fundamental physicochemical constants.
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- Butt, Salma, et al.
(författare)
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The Target for Statins, HMG-CoA Reductase, Is Expressed in Ductal Carcinoma-In Situ and May Predict Patient Response to Radiotherapy.
- 2014
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Ingår i: Annals of Surgical Oncology. - : Springer Science and Business Media LLC. - 1534-4681 .- 1068-9265. ; 21:9, s. 2911-2919
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Tidskriftsartikel (refereegranskat)abstract
- Patients with ductal carcinoma-in-situ (DCIS) are currently not prescribed adjuvant systemic treatment after surgery and radiotherapy. Prediction of DCIS patients who would benefit from radiotherapy is warranted. Statins have been suggested to exert radio-sensitizing effects. The target for cholesterol-lowering statins is HMG-CoA reductase (HMGCR), the rate-limiting enzyme in the mevalonate pathway. The aim of this study was to examine HMGCR expression in DCIS and study its treatment predictive value.
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| 4. |
- Ellinor, Patrick T., et al.
(författare)
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Meta-analysis identifies six new susceptibility loci for atrial fibrillation
- 2012
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Ingår i: Nature Genetics. - : Springer Science and Business Media LLC. - 1546-1718 .- 1061-4036. ; 44:6, s. 88-670
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Tidskriftsartikel (refereegranskat)abstract
- Atrial fibrillation is a highly prevalent arrhythmia and a major risk factor for stroke, heart failure and death(1). We conducted a genome-wide association study (GWAS) in individuals of European ancestry, including 6,707 with and 52,426 without atrial fibrillation. Six new atrial fibrillation susceptibility loci were identified and replicated in an additional sample of individuals of European ancestry, including 5,381 subjects with and 10,030 subjects without atrial fibrillation (P < 5 x 10(-8)). Four of the loci identified in Europeans were further replicated in silico in a GWAS of Japanese individuals, including 843 individuals with and 3,350 individuals without atrial fibrillation. The identified loci implicate candidate genes that encode transcription factors related to cardiopulmonary development, cardiac-expressed ion channels and cell signaling molecules.
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| 6. |
- Koettgen, Anna, et al.
(författare)
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Genome-wide association analyses identify 18 new loci associated with serum urate concentrations
- 2013
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Ingår i: Nature Genetics. - : Springer Science and Business Media LLC. - 1061-4036 .- 1546-1718. ; 45:2, s. 145-154
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Tidskriftsartikel (refereegranskat)abstract
- Elevated serum urate concentrations can cause gout, a prevalent and painful inflammatory arthritis. By combining data from >140,000 individuals of European ancestry within the Global Urate Genetics Consortium (GUGC), we identified and replicated 28 genome-wide significant loci in association with serum urate concentrations (18 new regions in or near TRIM46, INHBB, SEMBT1, TMEM171, VEGFA, BAZ1B, PRKAG2, STC1, HNF4G, A1CF, ATXN2, UBE2Q2, IGF1R, NFAT5, MAF, HLF, ACVR1B-ACVRL1 and B3GNT4). Associations for many of the loci were of similar magnitude in individuals of non-European ancestry. We further characterized these loci for associations with gout, transcript expression and the fractional excretion of urate. Network analyses implicate the inhibins-activins signaling pathways and glucose metabolism in systemic urate control. New candidate genes for serum urate concentration highlight the importance of metabolic control of urate production and excretion, which may have implications for the treatment and prevention of gout.
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| 7. |
- Lind, Carl, et al.
(författare)
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RAMP - Development of a risk assessment tool
- 2012
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Ingår i: NES2012 Ergonomics for sustainability and growth. - Stockholm. - 9789163711497 ; , s. 14s-
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Konferensbidrag (refereegranskat)abstract
- IntroductionManual Materials Handling (MMH) and working in awkward postures are still important causes of MSDs. Proper ergonomic conditions can contribute to reduce absence from work, and are important prerequisites to ensure high quality and productivity. Risk assessment can be used to improve the working conditions by identifying important risk factors and support communication between key stakeholders in order to improve the working conditions.This paper presents an ongoing project called RAMP (Risk management Assessment tool for Manual handling Proactively), reported e.g. at NES 2011. The aim of the project is to develop a freely accessible load ergonomic risk assessment tool and to gain knowledge of contributing factors for implementation and usability of such a tool. The RAMP-tool is developed for assessing risk of MSDs, support communication of the main risk factors among stakeholders and support effective interventions. The project, mainly financed by AFA Insurance, is conducted in collaboration between KTH and companies in the manufacturing industry, mainly Arla Foods and Scania CV.MethodsThis far an overview of risk assessment tools which can be used to assess MMH activities and potentially be used by companies or OSH personnel has been performed including e.g. KIM, QEC, ART Tool, SES and Washington State Checklist. Interviews with companies in the manufacturing industry have been performed to gain insight of the companies’ use of risk assessment tools and their perception of their usability.ResultsThe tool consists of two levels, RAMP I and RAMP II. The first level is intended for quick screening of work stations of occurrence (or not) of risk factors. If the screening indicates an occurrence of a risk factor, a more thorough analysis with the second level could be performed. RAMP II can be used for a more detailed analysis of the exposure to risk factors and point out the direction of possible improvements in order to reduce the exposure.A first prototype of the RAMP I has been evaluated by users, including managers, health and safety representatives, OSH personnel and workers.The tool will be further evaluated and refined after feedback from users. A preliminary version of the RAMP I will be presented at the conference and also preliminary results from the user tests.
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| 8. |
- Lind, Carl, et al.
(författare)
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RAMP: Risk Management Assessment Tool for Manual Handling Proactively
- 2014
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Ingår i: HUMAN FACTORS IN ORGANIZATIONAL DESIGN AND MANAGEMENT – XINORDIC ERGONOMICS SOCIETY ANNUAL CONFERENCE – 46. ; , s. 107-110
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Konferensbidrag (refereegranskat)abstract
- This paper presents an IT-based risk management tool called RAMP, risk assessment management tool for manual handling proactively. The tool consists of a checklist (RAMP I) and an assessment tool (RAMP II) which can be used to assess physicalrisk factors associated with manual handling activities in the production industry. The tool provides guidance for action plans and evaluations to promote improvement of occupational health and safety work at company level. Examples of the tool, its development and evaluation are presented.
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| 9. |
- Rose, Linda, et al.
(författare)
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Development, Implementation and dissemination of RAMP : Risk management assessment tool for manual handling proactively
- 2011
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Ingår i: 43rd Annual Nordic Ergonomics Society Conference. ; , s. 255-260
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Konferensbidrag (refereegranskat)abstract
- This paper describes an on-going project with the main objective to develop, implement, and disseminate a freely accessible computer-based assessment tool for physical ergonomics, the Risk Management Assessment Tool for Manual Handling Proactively, RAMP. The project is conducted in seven steps, in close co-operation between researchers and key company stakeholders, using an interactive research methodology. Results include a specification of requirements that the RAMP should meet. Difficulties of developing models of this kind and possible benefits of using such a tool are discussed.
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| 10. |
- Rose, Linda M, 1963-, et al.
(författare)
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Designing Jobs in Manufacturing : Rest Allowances
- 2012
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Konferensbidrag (övrigt vetenskapligt/konstnärligt)abstract
- The organization of work along a conventional production line layout has called for the consideration of both human (e.g., rest breaks, work pace) and technical factors, striving for the optimization of ergonomics and production. Linda Rose and Patrick Neumann discuss these issues in relation to muscle fatigue.
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