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Resting heart rate ...
Resting heart rate and risk of adverse cardiovascular outcomes in asymptomatic aortic stenosis : The SEAS study
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Greve, Anders M. (author)
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Bang, Casper N. (author)
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Berg, Ronan M. G. (author)
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Egstrup, Kenneth (author)
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Rossebo, Anne B. (author)
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- Boman, Kurt (author)
- Umeå universitet,Medicin,Skellefteå Research Unit
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Nienaber, Christoph A. (author)
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Ray, Simon (author)
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Gohlke-Baerwolf, Christa (author)
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Nielsen, Olav W. (author)
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Okin, Peter M. (author)
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Devereux, Richard B. (author)
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Kober, Lars (author)
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Wachtell, Kristian (author)
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(creator_code:org_t)
- Elsevier BV, 2015
- 2015
- English.
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In: International Journal of Cardiology. - : Elsevier BV. - 0167-5273 .- 1874-1754. ; 180, s. 122-128
- Related links:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Subject headings
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- Background: An elevated resting heart rate (RHR) may be an early sign of cardiac failure, but its prognostic value during watchful waiting in asymptomatic aortic stenosis (AS) is largely unknown. Methods: RHR was determined by annual ECGs in the Simvastatin and Ezetimibe in Aortic Stenosis (SEAS) study of asymptomatic mild-to-moderate AS patients. Primary endpoint in this substudy was major cardiovascular events (MCEs) and secondary outcomes its individual components. Multivariable Cox-models using serially-measured RHR were used to examine the prognostic impact of RHR per se. Results: 1563 patients were followed for a mean of 4.3 years (6751 patient-years of follow-up), 553 (35%) MCEs occurred, 10% (n = 151) died, including 75 cardiovascular deaths. In multivariable analysis, baseline RHR was independently associated with MCEs (HR 1.1 per 10 min(-1) faster, 95% CI: 1.0-1.3) and cardiovascular mortality (HR 1.3 per 10 min(-1) faster, 95% CI: 1.0-1.7, both p <= 0.03). Updating RHR with annual in-study reexaminations, time-varying RHR was highly associated with excess MCEs (HR 1.1 per 10 min(-1) faster, 95% CI: 1.1-1.3) and cardiovascular mortality (HR 1.4 per 10 min(-1) faster, 95% CI: 1.2-1.7, both p <= 0.006). The association of RHR with MCEs and cardiovascular mortality was not dependent on atrial fibrillation status (both p >= 0.06 for interaction). Conclusions: RHR is independently associated with MCEs and cardiovascular death in asymptomatic AS (Clinicaltrials.gov; unique identifier NCT00092677).
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Kardiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cardiac and Cardiovascular Systems (hsv//eng)
Keyword
- Aortic valve stenosis
- Resting heart rate
- Risk stratification
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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Greve, Anders M.
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Bang, Casper N.
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Berg, Ronan M. G ...
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Egstrup, Kenneth
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Rossebo, Anne B.
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Boman, Kurt
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show more...
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Nienaber, Christ ...
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Ray, Simon
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Gohlke-Baerwolf, ...
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Nielsen, Olav W.
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Okin, Peter M.
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Devereux, Richar ...
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Kober, Lars
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Wachtell, Kristi ...
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show less...
- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Cardiac and Card ...
- Articles in the publication
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International Jo ...
- By the university
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Umeå University