| 1. |
- Beshara, Soheir, et al.
(författare)
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Pharmacokinetics and red cell utilization of 52Fe/59Fe-labelled iron polymaltose in anaemic patients using positron emission tomography
- 2003
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Ingår i: British Journal of Haematology. - : Wiley. - 0007-1048 .- 1365-2141. ; 120:5, s. 853-859
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Tidskriftsartikel (refereegranskat)abstract
- Parenteral iron-polysaccharide complexes are increasingly applied. The pharmacokinetics of iron sucrose have been assessed by our group using positron emission tomography (PET). A single intravenous injection of 100 mg iron as iron (III) hydroxide-polymaltose complex, labelled with a tracer in the form of 52Fe/59Fe, was similarly assessed in six patients using PET for about 8 h. Red cell utilization was followed for 4 weeks. Iron polymaltose was similarly distributed to the liver, spleen and bone marrow. However, a larger proportion of this complex was rapidly distributed to the bone marrow. The shorter equilibration phase for the liver, about 25 min, indicates the minimal role of the liver for direct distribution. Splenic uptake also reflected the reticuloendothelial handling of this complex. Red cell utilization ranged from 61% to 99%. Despite the relatively higher uptake by the bone marrow, there was no saturation of marrow transport systems at this dose level. In conclusion, high red cell utilization of iron polymaltose occurred in anaemic patients. The major portion of the injected dose was rapidly distributed to the bone marrow. In addition, the reticuloendothelial uptake of this complex may reflect the safety of polysaccharide complexes. Non-saturation of transport systems to the bone marrow indicated the presence of a large interstitial transport pool, which might possibly be transferrin.
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| 4. |
- Ladjevardi, Sam, et al.
(författare)
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FDG-PET vic ockult bröstcancer
- 2002
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Ingår i: Läkartidningen. ; 99, s. 524-
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Tidskriftsartikel (övrigt vetenskapligt/konstnärligt)
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| 5. |
- Sörensen, Jens
(författare)
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Balkanism and the New Radical Interventionism: A Structural Critique
- 2003
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Ingår i: International Peacekeeping. - : Informa UK Limited. - 1353-3312 .- 1743-906X. ; 9:1, s. 1-22
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Tidskriftsartikel (refereegranskat)abstract
- Abstract This article presents a critique of the theory behind the new radical interventionism, both in its military disciplining form and in the form of a radical aid policy that attempts to change and control whole processes of social life by targeting mentalities and attitudes. The contention here is that the new interventionism, while appealing to moral and civil values, is as 'realist' oriented as ever. Moreover, the moralist discourse behind 'cosmopolitan policing' and 'humanitarian bombing' is shared within both the 'left' and the 'right' enabling a merger into a neo-liberal agenda with radical interventionist ambitions. This, in turn, has become possible by drawing on elements from three other discourses, thus creating a formula for a hegemonic project. These three discourses are: 'balkanism', 'universalism' and 'cultural nihilism'. We can contrast this with an alternative emphasis on how new forms of power are being worked out in the centre, as well as alternative projects developing in the periphery, each having their own logic and forms of legitimacy. This approach maintains the importance of agency and local power, while at the same time regarding them as embedded in a wider structural framework.
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| 6. |
- Sörensen, Jens, 1961-
(författare)
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PET in Heart Failure - Methods and Applications
- 2004
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Doktorsavhandling (övrigt vetenskapligt/konstnärligt)abstract
- Positron Emission Tomography (PET) permits regional myocardial perfusion, fibrosis and oxidative metabolism to be non-invasively quantified with radioactive tracers such as [15O]-water and [1-11C]-acetate. PET is an established research tool in congestive heart failure (CHF), a major cause of morbidity and mortality. However, as CHF is a syndrome that eventually affects all aspects of cardiac and systemic hemodynamic function, more clinically relevant information from a single PET scan is desirable. The aim of this thesis therefore was to develop and implement some new concepts in cardiac PET.A new method for the measurement of cardiac output with any tracer was validated in animal experiments and CHF patients. The early pulmonary retention of [1-11C]-acetate was inversely related to left ventricular (LV) function in animals and was directly proportional to lung water content and severity of LV diastolic dysfunction in patients.Eight patients with acute myocardial infarction were followed with serial PET from 3 hours to 3 weeks after trombolytic treatment. PET revealed that myocardial perfusion and the extraction and utilization of fuel substrates all decreased closer to the infarct centre. The rate of oxygen utilization within the infarct at 3 h predicted degree of myocardial fibrosis, pulmonary oedema and tissue viability at 3 weeks. Seventeen patients with CHF due to chronic ischemic cardiomyopathy and severely reduced LV function were evaluated with [1-11C]-acetate PET before and after coronary artery bypass surgery. There was a dramatic improvement in physical performance and symptoms, which was not correlated to the standard LV ejection indices. PET revealed that functional improvement was associated with improved LV loading conditions, reversed remodeling and homogenization of oxidative metabolism rather than increased output.
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| 7. |
- Sörensen, Jens
(författare)
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Questioning Reconstruction
- 2001
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Ingår i: Bieber, F & Z. Daskalovski "Understanding the War in Kosovo". - : Routledge.
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Bokkapitel (refereegranskat)
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| 8. |
- Sörensen, Jens, et al.
(författare)
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Rapid bone and blood flow formation in impacted morselized allografts : positron emission tomography (PET) studies on allografts in 5 femoral component revisions of total hip arthroplasty.
- 2003
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Ingår i: Acta Orthop Scand. - 0001-6470. ; 74:6, s. 633-43
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Tidskriftsartikel (refereegranskat)abstract
- 5 patients were revised with impaction of morselized frozen allograft and a cemented total hip arthroplasty (THA) because of loosening and osteolysis of a primary hip arthroplasty. Plain film radiographs of the stems showed stable implants in all patients 15-24 months after surgery. The clinical results were good. We used: 1) Positron Emission Tomography (PET) to evaluate vascularization and new bone formation in the allograft, 2) kinetic [18F]-fluoride PET to produce quantitative images, interpreted as new bone formation in the allograft surrounding the femur stem, 3) [15O]-water PET to quantify bone blood flow, and 4) [15O]-carbon monoxide to determine blood volume. After surgery, all patients were evaluated twice: at 1-8 days and 12 months and 3 patients were also studied at 4 months. As early as at 8 days after surgery, blood flow and bone formation had increased greatly adjacent to the allograft. At 4 months blood flow and bone formation were about the same, but activity was highest in the graft material. At 1 year after surgery, blood flow had declined to the levels of the contralateral femur diaphysis in most of the graft bed. These findings using the PET technique showed that angiogenesis and new bone formation occurred early after impaction of morselized bone allografts around the femoral component in revision THA. We found that PET is a sensitive method for evaluating neovascularization and bone formation in the graft beds.
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| 9. |
- Sörensen, Jens, et al.
(författare)
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Simple and accurate assessment of forward cardiac output by use of 1-[11C]acetate PET verified in a pig model
- 2003
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Ingår i: Journal of Nuclear Medicine. - 0161-5505 .- 1535-5667. ; 44:7, s. 1176-1183
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Tidskriftsartikel (refereegranskat)abstract
- Dynamic 1-(11)C-acetate PET (AC-PET) allows quantification of myocardial blood flow and oxidative metabolism. We wanted to determine the accuracy of AC-PET in measuring cardiac output (CO) using first-pass analysis and the indicator dilution principle. Further, we wanted to investigate the pulmonary uptake of acetate in relation to left atrial filling pressures and ventricular function.METHODS: Twenty-four steady-state experiments were performed in 5 domestic pigs. Pulmonary capillary wedge pressure (PCWP) and CO by thermodilution (CO(thermo)) were recorded invasively simultaneous with AC-PET scans at baseline (n = 9), dobutamine infusion (n = 6), high-dose metoprolol and morphine (n = 6), and angiotensinamide infusion (n = 3). 1-(11)C-Acetate was injected as a rapid manual bolus. Regions of interest (ROIs) were placed in the right (RV) and left (LV) heart cavities. Time-activity curves were constructed and the area under the curve (AUC) was integrated from beginning the scan to the time of visually determined recirculation by simple arithmetic. CO by PET (CO(PET)) was calculated as injected dose/AUC. Image handling and curve analysis were repeated by a blinded observer. Total pulmonary extravascular retention of (11)C, expressed as percentage of injected dose (lung-uptake %ID), was measured using a combination of transmission, (15)O-carbon monoxide, and AC-PET scans.RESULTS: CO(thermo) ranged from 2.1 to 8.2 L/min. CO(PET) determined from both LV and RV was linearly related to CO(thermo) with slopes close to 1 (LV, r = 0.98; RV, r = 0.96; both P < 0.001). Interobserver reproducibility was r = 0.98, P < 0.001. The PCWP range was 6-14 mm Hg and the lung-uptake %ID was 2.7-8.5 %ID. When normalized to baseline, lung-uptake %ID was correlated with PCWP (r = 0.56, P = 0.01) and linearly correlated with LV input resistance (PCWP divided by CO(thermo); r = 0.91, P < 0.001). When both lung-uptake %ID and stroke volume were normalized to baseline, a piecewise linear relation was found (r = 0.95, P < 0.001).CONCLUSION: Our results suggest that measurements of CO by AC-PET are feasible and accurate. Using RV ROIs might favor CO measurements by any injectable PET tracer. The lung-uptake %ID might be useful in evaluation of pulmonary congestion, but further studies are needed.
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| 10. |
- Sörensen, Jens
(författare)
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War as Social Transformation: Wealth Class, Power and an Illiberal Economy in Serbia
- 2003
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Ingår i: Civil Wars. - 1369-8249. ; 6:4, s. 55-82
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Tidskriftsartikel (refereegranskat)abstract
- This article analyses changes in the social structure and stratification of Serbian society in the 1990 ‘s and the development of an illiberal economy. These developments are discussed in context of three competing theoretical frameworks here called: the ‘transitional’ perspective, the ‘social breakdown’ interpretation, and the perspective of ‘social transformation’. The article argues that the two former perspectives imply assumptions of ‘transition to liberal democracy and market economy, in the first case, and the possibility of ‘reconstruction’ of shattered institutions and processes, in the second and that these assumptions need further scrutiny. The metaphor ‘social transformation’ instead emphasizes the importance of considering the ‘actually’ existing forms of political economy, survival strategies, social networks, and processes in the region without assuming linear developments of ‘reconstruction’, or ‘transition’ towards liberal‐democracy cum market economy. The ‘language’ we use to describe and identify problems, i.e. how we conceptualise, are central also to the policy‐implications they have. The development of illiberal forms of economy in the former Yugoslav space, in this case Serbia, may be considered part of a political project in itself. The ‘sources’ on parallel, often extra‐legal, economic forms of activity are very scarce and there is a huge methodological problem in how to access and analyse the character, scope and meaning of this. However, the phenomenon is too important to be avoided just due to a lack of sources, and preliminary analysis and discussion is necessary even though it has of necessity to be based on ‘soft’ sources. In this article such ‘soft’ material includes local newspaper material, informal interviews with local informants and preliminary estimations. After having discussed the economy of inflation, examples of black‐grey forms of economy, individual survival‐strategies, and changes in the stratification of Serbian society this article identifies forces within Serbian society which are supportive of what may be termed the illiberal project and those forces ranged against it. While it may be premature to base any conclusion for which forces may be in the longer‐term be sustainable, there is utility in research into both the nature of the illiberal economy, the social networks and forces benefiting from it and the level of cohesion/fragmentation amongst the opposition/resistance to it.
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