| 1. |
- Sandstrom, Maria, et al.
(författare)
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A Retrospective Evaluation of Bevacizumab Treatment in Patients with Progressive Malignant Glioma in Northern Sweden
- 2017
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Ingår i: Anticancer Research. - : INT INST ANTICANCER RESEARCH. - 0250-7005 .- 1791-7530. ; 37:4, s. 1869-1874
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Tidskriftsartikel (refereegranskat)abstract
- Background/Aim: Overall survival for glioblastoma patients is short. Standard treatment is surgery followed by radiochemotherapy and adjuvant temozolomide. The aim of this study was to evaluate the outcome for all patients with progressive disease treated with bevacizumab-based treatment combinations in the northern region of Sweden. Patients and Methods: This was a single-center retrospective analysis after bevacizumab-based second-line treatment for malignant glioma. All patients treated with bevacizumab, between 2007 and 2011 in our Center were retrospectively evaluated. Results: Progression-free survival after the start of bevacizumab-based treatment was 20 weeks and overall survival was 31 weeks. Treatment was well tolerated, but 9% of patients (n=6) suffered from serious adverse events. In 68% of patients, a >= 25% decrease in contrast enhancement was seen at best response. Conclusion: Results from this retrospective study are comparable with earlier phase-II. studies and motivate randomized trials of bevacizumab-based treatment in the second-line setting.
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| 2. |
- Battersby, C., et al.
(författare)
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The Origins Space Telescope
- 2018
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Ingår i: Nature Astronomy. - : Springer Science and Business Media LLC. - 2397-3366. ; 2:8, s. 596-599
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Tidskriftsartikel (övrigt vetenskapligt/konstnärligt)abstract
- The Origins Space Telescope, one of four large Mission Concept Studies sponsored by NASA for review in the 2020 US Astrophysics Decadal Survey, will open unprecedented discovery space in the infrared, unveiling our cosmic origins.
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| 3. |
- Faragardi, Hamid Reza, et al.
(författare)
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EAICA : An energy-aware resource provisioning algorithm for Real-Time Cloud services
- 2016
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Ingår i: IEEE International Conference on Emerging Technologies and Factory Automation, ETFA. - 9781509013142
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Konferensbidrag (refereegranskat)abstract
- Cloud computing is receiving an increasing attention when it comes to providing a wide range of cost-effective services. In this context, energy consumption of communication and computing resources contribute to a major portion of the cost of services. On the other hand, growing energy consumption not only results in a higher operational cost, but it also causes negative environmental impacts. A large number of cloud applications in, e.g., telecommunication, multimedia, and video gaming, have real-time requirements. A cloud computing system hosting such applications, that requires a strict timing guarantee for its provided services, is denoted a Real-Time Cloud (RTC). Minimizing energy consumption in a RTC is a complicated task as common methods that are used for decreasing energy consumption can potentially lead to timing violations. In this paper, we present an online energy-aware resource provisioning framework to reduce the deadline miss ratio for real-time cloud services. The proposed provisioning framework not only considers the energy consumption of servers but it also takes the energy consumption of the communication network into account, to provide a holistic solution. An extensive range of simulation results, based on real data, show a noticeable improvement regarding energy consumption while keeping the number of timing violations less than 1% in average.
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| 4. |
- Leisawitz, David, et al.
(författare)
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The origins space telescope
- 2019
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Ingår i: Proceedings of SPIE - The International Society for Optical Engineering. - : SPIE. - 0277-786X .- 1996-756X. ; 11115
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Konferensbidrag (refereegranskat)abstract
- The Origins Space Telescope will trace the history of our origins from the time dust and heavy elements permanently altered the cosmic landscape to present-day life. How did galaxies evolve from the earliest galactic systems to those found in the universe today? How do habitable planets form? How common are life-bearing worlds? To answer these alluring questions, Origins will operate at mid-and far-infrared wavelengths and offer powerful spectroscopic instruments and sensitivity three orders of magnitude better than that of Herschel, the largest telescope flown in space to date. After a 3 1/2 year study, the Origins Science and Technology Definition Team will recommend to the Decadal Survey a concept for Origins with a 5.9-m diameter telescope cryocooled to 4.5 K and equipped with three scientific instruments. A mid-infrared instrument (MISC-T) will measure the spectra of transiting exoplanets in the 2.8-20 μm wavelength range and offer unprecedented sensitivity, enabling definitive biosignature detections. The Far-IR Imager Polarimeter (FIP) will be able to survey thousands of square degrees with broadband imaging at 50 and 250 μm. The Origins Survey Spectrometer (OSS) will cover wavelengths from 25-588 μm, make wide-area and deep spectroscopic surveys with spectral resolving power R ∼ 300, and pointed observations at R ∼ 40,000 and 300,000 with selectable instrument modes. Origins was designed to minimize complexity. The telescope has a Spitzer-like architecture and requires very few deployments after launch. The cryo-thermal system design leverages JWST technology and experience. A combination of current-state-of-the-art cryocoolers and next-generation detector technology will enable Origins' natural backgroundlimited sensitivity.
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| 5. |
- Leisawitz, David, et al.
(författare)
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The Origins Space Telescope: Mission concept overview
- 2018
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Ingår i: Proceedings of SPIE - The International Society for Optical Engineering. - : SPIE. - 0277-786X .- 1996-756X. ; 10698
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Konferensbidrag (refereegranskat)abstract
- Downloading of the abstract is permitted for personal use only. The Origins Space Telescope (OST) will trace the history of our origins from the time dust and heavy elements permanently altered the cosmic landscape to present-day life. How did the universe evolve in response to its changing ingredients? How common are life-bearing planets? To accomplish its scientific objectives, OST will operate at mid- and far-infrared wavelengths and offer superlative sensitivity and new spectroscopic capabilities. The OST study team will present a scientifically compelling, executable mission concept to the 2020 Decadal Survey in Astrophysics. To understand the concept solution space, our team studied two alternative mission concepts. We report on the study approach and describe both of these concepts, give the rationale for major design decisions, and briefly describe the mission-enabling technology.
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| 6. |
- Meixner, Margaret, et al.
(författare)
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Overview of the Origins Space telescope: Science drivers to observatory requirements
- 2018
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Ingår i: Proceedings of SPIE - The International Society for Optical Engineering. - : SPIE. - 0277-786X .- 1996-756X. ; 10698
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Konferensbidrag (refereegranskat)abstract
- The Origins Space Telescope (OST) mission concept study is the subject of one of the four science and technology definition studies supported by NASA Headquarters to prepare for the 2020 Astronomy and Astrophysics Decadal Survey. OST will survey the most distant galaxies to discern the rise of metals and dust and to unveil the co-evolution of galaxy and blackhole formation, study the Milky Way to follow the path of water from the interstellar medium to habitable worlds in planetary systems, and measure biosignatures from exoplanets. This paper describes the science drivers and how they drove key requirements for OST Mission Concept 2, which will operate between ∼5 and ∼600 microns with a JWST sized telescope. Mission Concept 2 for the OST study optimizes the engineering for the key science cases into a powerful and more economical observatory compared to Mission Concept 1.
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| 9. |
- Thurston, George D, et al.
(författare)
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A joint ERS/ATS policy statement : what constitutes an adverse health effect of air pollution? An analytical framework
- 2017
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Ingår i: European Respiratory Journal. - : European Respiratory Society (ERS). - 0903-1936 .- 1399-3003. ; 49:1
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Tidskriftsartikel (refereegranskat)abstract
- The American Thoracic Society has previously published statements on what constitutes an adverse effect on health of air pollution in 1985 and 2000. We set out to update and broaden these past statements that focused primarily on effects on the respiratory system. Since then, many studies have documented effects of air pollution on other organ systems, such as on the cardiovascular and central nervous systems. In addition, many new biomarkers of effects have been developed and applied in air pollution studies.This current report seeks to integrate the latest science into a general framework for interpreting the adversity of the human health effects of air pollution. Rather than trying to provide a catalogue of what is and what is not an adverse effect of air pollution, we propose a set of considerations that can be applied in forming judgments of the adversity of not only currently documented, but also emerging and future effects of air pollution on human health. These considerations are illustrated by the inclusion of examples for different types of health effects of air pollution.
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