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Träfflista för sökning "WFRF:(Shi M.) srt2:(1995-1999)"

Search: WFRF:(Shi M.) > (1995-1999)

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  • Babcock, Gerald T, et al. (author)
  • Tyrosyl radicals in enzyme catalysis: Some properties and a focus on photosynthetic water oxidation
  • 1997
  • In: Acta Chemica Scandinavica. - 0904-213X. ; 51:5, s. 533-540
  • Journal article (peer-reviewed)abstract
    • Enzymes that require a redox-active amino acid for catalysis or function have emerged as a distinct class of proteins. For the tyrosine-based radical enzymes, we show that the spin-density distribution in the radical follows an odd alternate pattern that is invariant to within 10% across the class. General properties of the radical enzymes are summarized from which we conclude that their essential role in catalysis is to initiate substrate metabolism by hydrogen-atom abstraction. These ideas are extended to the Y-Z and Y-D tyrosines in Photosystem II and a radical-based hydrogen-atom abstraction model for water oxidation is discussed. Differences in rates of oxidation of Y-Z and Y-D by the reaction-center chlorophyll, P680(+), under various conditions, are considered and rationalized on the basis of changes in reorganization energy induced by the local protein structure and by the presence or absence of the (Mn)(4) cluster that binds substrate water.
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  • Shi, Guo-Ping, et al. (author)
  • Cystatin C deficiency in human atherosclerosis and aortic aneurysms
  • 1999
  • In: Journal of Clinical Investigation. - 0021-9738. ; 104:9, s. 1191-1197
  • Journal article (peer-reviewed)abstract
    • The pathogenesis of atherosclerosis and abdominal aortic aneurysm involves breakdown of the elastic laminae. Elastolytic cysteine proteases, including cathepsins S and K, are overexpressed at sites of arterial elastin damage, but whether endogenous local inhibitors counterbalance these proteases is unknown. We show here that, whereas cystatin C is normally expressed in vascular wall smooth muscle cells (SMCs), this cysteine protease inhibitor is severely reduced in both atherosclerotic and aneurysmal aortic lesions. Furthermore, increased abdominal aortic diameter among 122 patients screened by ultrasonography correlated inversely with serum cystatin C levels. In vitro, cytokine-stimulated vascular SMCs secrete cathepsins, whose elastolytic activity could be blocked when cystatin C secretion was induced by treatment with TGF-beta(1). The findings highlight a potentially important role for imbalance between cysteine proteases and cystatin C in arterial wall remodeling and establish that cystatin C deficiency occurs in vascular disease.
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  • Result 1-10 of 13

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