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Down-regulation of ...
Down-regulation of the oncogene cyclin D1 increases migratory capacity in breast cancer and is linked to unfavorable prognostic features.
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- Lehn, Sophie (författare)
- Lund University,Lunds universitet,Tumörmikromiljö,Sektion I,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Patologi, Malmö,Forskargrupper vid Lunds universitet,Tumor microenvironment,Section I,Department of Clinical Sciences, Lund,Faculty of Medicine,Pathology, Malmö,Lund University Research Groups
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- Tobin, Nicholas P (författare)
- Lund University,Lunds universitet,Patologi, Malmö,Forskargrupper vid Lunds universitet,Pathology, Malmö,Lund University Research Groups
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- Berglund, Pontus (författare)
- Lund University,Lunds universitet,Experimentell patologi, Malmö,Forskargrupper vid Lunds universitet,Patologi, Malmö,Experimental Pathology, Malmö,Lund University Research Groups,Pathology, Malmö
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- Nilsson, Kristina (författare)
- Lund University,Lunds universitet,Patologi, Malmö,Forskargrupper vid Lunds universitet,Pathology, Malmö,Lund University Research Groups
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Sims, Andrew H (författare)
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- Jirström, Karin (författare)
- Lund University,Lunds universitet,Tumörmikromiljö,Sektion I,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Tumor microenvironment,Section I,Department of Clinical Sciences, Lund,Faculty of Medicine
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- Härkönen, Pirkko (författare)
- Lund University,Lunds universitet,Institutionen för translationell medicin,Medicinska fakulteten,Department of Translational Medicine,Faculty of Medicine
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Lamb, Rebecca (författare)
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- Landberg, Göran, 1963 (författare)
- Lund University,Lunds universitet,Gothenburg University,Göteborgs universitet,Institutionen för biomedicin, avdelningen för patologi,Institute of Biomedicine, Department of Pathology,Patologi, Malmö,Forskargrupper vid Lunds universitet,Pathology, Malmö,Lund University Research Groups
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(creator_code:org_t)
- Elsevier BV, 2010
- 2010
- Engelska.
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Ingår i: The American journal of pathology. - : Elsevier BV. - 1525-2191 .- 0002-9440. ; 177:6, s. 2886-97
- Relaterad länk:
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Abstract
Ämnesord
Stäng
- The oncogene cyclin D1 is highly expressed in many breast cancers and, despite its proliferation-activating properties, it has been linked to a less malignant phenotype. To clarify this observation, we focused on two key components of malignant behavior, migration and proliferation, and observed that quiescent G(0)/G(1) cells display an increased migratory capacity compared to cycling cells. We also found that the down-regulation of cyclin D1 in actively cycling cells significantly increased migration while also decreasing proliferation. When analyzing a large set of premenopausal breast cancers, we observed an inverse proliferation-independent link between cyclin D1 and tumor size and recurrence, suggesting that this protein might abrogate infiltrative malignant behavior in vivo. Finally, gene expression analysis after cyclin D1 down-regulation by siRNA confirmed changes in processes associated with migration and enrichment of our gene set in a metastatic poor prognosis signature. This novel function of cyclin D1 illustrates the interplay between tumor proliferation and migration and may explain the attenuation of malignant behavior in breast cancers with high cyclin D1 levels.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Cell- och molekylärbiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Cell and Molecular Biology (hsv//eng)
Nyckelord
- Breast Neoplasms
- diagnosis
- genetics
- pathology
- Carcinoma
- diagnosis
- genetics
- pathology
- Cell Movement
- drug effects
- genetics
- Cell Proliferation
- Cyclin D1
- antagonists & inhibitors
- genetics
- metabolism
- physiology
- Down-Regulation
- drug effects
- genetics
- physiology
- Female
- Gene Expression Profiling
- Gene Expression Regulation
- Neoplastic
- physiology
- Humans
- Microarray Analysis
- Neoplasm Invasiveness
- Oncogenes
- genetics
- physiology
- Prognosis
- RNA
- Small Interfering
- pharmacology
- Tumor Cells
- Cultured
- Tumor Markers
- Biological
- genetics
- metabolism
- physiology
- Up-Regulation
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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- Av författaren/redakt...
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Lehn, Sophie
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Tobin, Nicholas ...
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Berglund, Pontus
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Nilsson, Kristin ...
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Sims, Andrew H
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Jirström, Karin
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visa fler...
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Härkönen, Pirkko
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Lamb, Rebecca
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Landberg, Göran, ...
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visa färre...
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- MEDICIN OCH HÄLSOVETENSKAP
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- Av lärosätet
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Göteborgs universitet
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Lunds universitet