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- Laurencikas, E, et al.
(författare)
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Metacarpophalangeal pattern profile analysis as a tool for early diagnosis of Turner syndrome
- 2005
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Ingår i: Acta radiologica (Stockholm, Sweden : 1987). - : SAGE Publications. - 0284-1851 .- 1600-0455. ; 46:4, s. 424-430
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Tidskriftsartikel (refereegranskat)abstract
- Purpose: To analyze the metacarpophalangeal pattern profile (MCPP) in a cohort of individuals with Turner syndrome (TS), and to assess its value as a tool for early diagnosis of TS. Material and Methods: Medical records and radiological material were collected of 71 patients with TS aged between 3 and 21 years. Forty‐six patients received growth hormone therapy (33–66 µg kg−1 day−1) and 14 of these were also treated with the anabolic steroid oxandrolone (1.25–3.75 mg day−1). A total of 233 frontal hand radiographs were studied and pattern profiles were calculated. Profiles of the TS patients were compared with those of 70 normal females. Mean pattern profiles were calculated for different age groups and extrapolated profiles for newborns and infants were developed. Results: Our results confirm that patients with TS have a distinct MCPP which differs significantly from that of normal individuals. A bone‐shortening gradient with increasing shortening from distal phalanges to metacarpals was demonstrated. We also showed that the MCPP in TS is a remarkably constant feature from 3 to 18 years. Pattern profiles did not differ significantly between the patients with 45,X and non‐45,X karyotype. MCPP was not affected by treatment with growth hormone of growth hormone plus oxandrolone. Discriminant analysis yielded correct classification in 88% of analyzed cases. Conclusion: TS individuals have a distinct hand pattern profile that is not age‐related. MCPP analysis can be applied at any age and may facilitate early diagnosis of TS. Our study showed that MCPP analysis is a specific and sensitive method that should be considered as a routinely used tool for early diagnosis of TS in girls with unexplained short stature.
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| 2. |
- Laurencikas, E, et al.
(författare)
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Metacarpophalangeal pattern profile analysis in Leri-Weill dyschondrosteosis
- 2005
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Ingår i: Acta radiologica (Stockholm, Sweden : 1987). - : SAGE Publications. - 0284-1851 .- 1600-0455. ; 46:2, s. 200-207
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Tidskriftsartikel (refereegranskat)abstract
- Purpose: To analyze the metacarpophalangeal profile (MCPP) in individuals with Leri‐Weill dyschondrosteosis (LWD) and to assess its value as a possible contributor to early diagnosis. Material and Methods: Hand profiles of 39 individuals with a diagnosis of LWD were calculated and analyzed. Discriminant analysis was applied to differentiate between LWD and normal individuals. Results: There was a distinct pattern profile in LWD. Mean pattern profile showed two bone‐shortening gradients, with increasing shortening from distal to proximal and from medial to lateral. Distal phalanx 2 was disproportionately long and second metacarpal was disproportionately short. Discriminant analysis yielded correct classification in 72% of analyzed cases. Conclusion: MCPP is not age‐related and the analysis can be applied at any age, facilitating early diagnosis of LWD. In view of its availability, low costs, and diagnostic value, MCPP analysis should be considered as a routine method in the patients of short stature where LWD is suspected.
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| 6. |
- Soderman, M, et al.
(författare)
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Neurovascular radiosurgery
- 2006
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Ingår i: Interventional neuroradiology : journal of peritherapeutic neuroradiology, surgical procedures and related neurosciences. - : SAGE Publications. - 1591-0199. ; 12:3, s. 189-202
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Tidskriftsartikel (refereegranskat)abstract
- This article focuses on the treatment of neurovascular diseases, in particular brain arteriovenous malformations (BAVMs), with radiosurgery. The target group for this review is physicians who manage patients with neurovascular diseases, but are not actively engaged in radiosurgery. Radiosurgery for BAVMs is an established treatment with clearly defined risks and benefits. The efficacy of radiosurgery for dural arteriovenous shunts (DAVSs) is probably similar but the treatment has not yet gained the same acceptance. Radiosurgical treatment of cavernomas (cavernous hemangiomas) remains controversial. Well founded predictive models for BAVM radiosurgery show: The probability of obliteration depends on the dose of radiation given to the periphery of the BAVM. The risk of adverse radiation effects depends on the total dose of radiation, i.e. the amount of energy imparted into the tissue. The risk is greater in centrally located lesions. The risk of damage to brainstem nucleii and cranial nerves must be added to the risk predicted from current outcome models. The risk of hemorrhage during the time span before obliteration depends on the BAVM volume, the dose of radiation to the periphery of the lesion and the age of the patient. Central location is a probably also a risk factor.
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