| 1. |
- Vanhanen, Sanna-Leena, et al.
(författare)
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Neuroradiological findings (MRS, MRI, SPECT) in infantile neuronal ceroid-lipofuscinosis (infantile CLN1) at different stages of the disease.
- 2004
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Ingår i: Neuropediatrics. - : Georg Thieme Verlag KG. - 0174-304X .- 1439-1899. ; 35:1, s. 27-35
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Tidskriftsartikel (refereegranskat)abstract
- Infantile neuronal ceroid-lipofuscinosis (infantile CLN1) is a progressive and uniformly fatal lysosomal storage disease of the nervous system. The purpose of this study was to compare the findings of various radiological examinations of the brain in the course of infantile CLN1 in order to evaluate the relative usefulness of the methods and their potential for monitoring therapeutic interventions. We examined eight infantile CLN1 patients, 51 studies, in various stages of the disease--preclinical to late stage--with proton magnetic resonance spectroscopy (1H-MRS), MRI, and perfusion SPECT, and in addition three benzodiazepine (BZ) receptor ligand SPECT studies. Both 1H-MRS and MRI showed abnormal findings before clinical manifestations of the disease. Cortical hypoperfusion and loss of cortical BZ receptors revealed by SPECT appeared simultaneously with clinical signs. After the age of 4 years MRI and SPECT alterations progressed minimally, whereas 1H-MRS showed progressive deterioration of neurometabolism. Of the four methods used in this study, MRI proved to be the most practicable for diagnosing infantile CLN1; the final diagnosis of infantile CLN1 is confirmed by the characteristic clinical picture and DNA or PPT enzyme analysis. The combination of 1H- MRS and MRI could be most useful for monitoring therapeutic interventions.
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| 2. |
- Lundh, Emil, et al.
(författare)
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Rotational states of Bose gases with attractive interactions in anharmonic traps
- 2004
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Ingår i: Physical Review Letters. - 0031-9007 .- 1079-7114. ; 92:7, s. 070401-
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Tidskriftsartikel (refereegranskat)abstract
- A rotated and harmonically trapped Bose gas with attractive interactions is expected to either remain stationary or escape from the trap. Here we report that, on the contrary, in an anharmonic trapping potential the Bose gas with attractive interactions responds to external rotation very differently, namely, through center-of-mass motion or by formation of vortices.
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| 3. |
- Piilo, J., et al.
(författare)
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Radiative collisional heating at the Doppler limit for laser-cooled magnesium atoms
- 2004
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Ingår i: Physical Review A. Atomic, Molecular, and Optical Physics. - 1050-2947 .- 1094-1622. ; 70:1
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Tidskriftsartikel (refereegranskat)abstract
- We report Monte Carlo wave function simulation results on cold collisions between magnesium atoms in a strong red-detuned laser field. This is the normal situation, e.g., in magneto-optical traps (MOT). The Doppler limit heating rate due to radiative collisions is calculated for Mg-24 atoms in an MOT based on the S-1(0)-P-1(1) atomic laser cooling transition. We find that radiative heating does not seem to affect the Doppler limit in this case. We also describe a channeling mechanism due to the missing Q branch in the excitation scheme, which could lead to a suppression of inelastic collisions, and find that this mechanism is not present in our simulation results due to the multistate character of the excitation process.
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