| 1. |
- Svensson, Per Anders, 1959, et al.
(författare)
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Identification of genes predominantly expressed in human macrophages
- 2004
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Ingår i: Atherosclerosis. - : Elsevier BV. ; 177, s. 287-290
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Tidskriftsartikel (refereegranskat)abstract
- Identification of cell and tissue specific genes may provide novel insights to signaling systems and functions. Macrophages play a key role in many diseases including atherosclerosis. Using DNA microarrays we compared the expression of approximately 10,000 genes in 56 human tissues and identified 23 genes with predominant expression in macrophages. The identified genes include both genes known to be macrophage specific and genes previously not well described in this cell type. Tissue distribution of two genes, liver X receptor (LXR) alpha and interleukin-1 receptor antagonist (IL1RN), was verified by real-time RT-PCR. We conclude that comparison of expression profiles from a large number of tissues can be used to identify genes that are predominantly expressed in certain tissues. Identification of novel macrophage specific genes may increase our understanding of the role of this cell in different diseases.
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| 2. |
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| 3. |
- Andersson, Daniel, 1977, et al.
(författare)
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On Skin Effect in On-Chip Interconnects
- 2004
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Ingår i: Intl Workshop on Power and Timing Modeling, Optimization and Simulation (PATMOS). - Berlin, Heidelberg : Springer Berlin Heidelberg. ; , s. 463-470
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Konferensbidrag (refereegranskat)abstract
- We investigate the influence of skin effect on the propagation delays of on-chip interconnects. For long wires, designed in the LC regime, on the top metal layer in a contemporary process, we find that the skin effect causes an extra delay by 10%. The impact of the skin effect on delay is furthermore rapidly increasing with increased interconnect width.
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| 4. |
- Eckerbert, Daniel, 1973, et al.
(författare)
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A Mixed-Mode Delay-Locked Loop Architecture
- 2003
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Ingår i: Proceedings of the 21st International Conference on Computer Design (ICCD), San Jose, 13-15 October 2003. - 1063-6404. - 0769520251 ; , s. 261-263
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Konferensbidrag (refereegranskat)abstract
- We present a mixed-mode delay-locked loop (DLL) architecture intended for multiple-phase clock generation. In contrast to analog DLLs, the proposed architecture allows for clock-gating; moreover circuit simulations indicate that its performance (in terms of maximum frequency, frequency range, and low-speed power dissipation) is superior to that of a previously-reported, purely digital DLL.
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| 5. |
- Filippini, Daniel, et al.
(författare)
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Microplate based biosensing with a computer screen aided technique
- 2003
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Ingår i: Biosensors & bioelectronics. - 0956-5663 .- 1873-4235. ; 19:1, s. 35-41
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Tidskriftsartikel (refereegranskat)abstract
- Melanophores, dark pigment cells from the frog Xenopus laevis, have the ability to change light absorbance upon stimulation by different biological agents. Hormone exposure (e.g. melatonin or α-melanocyte stimulating hormone) has been used here as a reversible stimulus to test a new compact microplate reading platform. As an application, the detection of the asthma drug formoterol in blood plasma samples is demonstrated. The present system utilizes a computer screen as a (programmable) large area light source, and a standard web camera as recording media enabling even kinetic microplate reading with a versatile and broadly available platform, which suffices to evaluate numerous bioassays. Especially in the context of point of care testing or self testing applications these possibilities become advantageous compared with highly dedicated comparatively expensive commercial systems.
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| 6. |
- Hallin, Karl, 1977, et al.
(författare)
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Modelling Information for Mechatronic Products
- 2003
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Ingår i: Proceedings of ICED 03. ; :1331, s. 11-
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Tidskriftsartikel (refereegranskat)abstract
- In mechatronic product development, there is a lack of a common understanding among different engineering domains, regarding the design. One step in improving this situation is to develop information models capable of representing both hardware and software elements. The objective of this paper is to investigate the Chromosome Model’s ability with respect to the mechatronic product and also to suggest an information model which implements its principles. The approach takes its point of departure on a theoretical level by analysing theories from mechanical and software engineering. Further, software concepts of relevance are incorporated into the Chromosome Model. The result, referred to as a meta model, is then transformed to an information model by utilising STEP AP214. Both the meta model and the information model are validated with an industrial example. The conclusions drawn from the work are that the Chromosome Model can be used as a meta model for mechatronic products and that STEP AP214 can be deployed within the scope of the meta model. The resulting information model captures the functional, causal and spatial relationships of a mechatronic product.
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| 7. |
- Isaksson, Ola, et al.
(författare)
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Trends in product modelling : an ENDREA perspective
- 2000
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Ingår i: Proceedings / Produktmodeller 2000. - Linköping : Linköping universitet.
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Konferensbidrag (refereegranskat)abstract
- The success of engineering companies is highly dependent on how well product information is managed, engineered and communicated. From marketing through development to after sales activities, data needs to be accessible and used in the best way. Today, geographical distance, the need for close co-operation and data complexity are all natural parts of the working environment. Product modelling techniques are continuously evolving with new requirements and opportunities emerging daily. This paper will outline and discuss some of these trends, and at the same time present some of the areas where research is being carried out within projects in the Product Model Cluster in the national graduate school - The Swedish Engineering Design Research and Education Agenda (ENDREA).
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| 8. |
- Karlgren, Daniel, et al.
(författare)
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High-angular-momentum structures in Zn-64
- 2004
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Ingår i: Physical Review C. Nuclear Physics. - 0556-2813 .- 1089-490X. ; 69, s. 1-034330
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Tidskriftsartikel (refereegranskat)abstract
- High-angular-momentum states in Zn-64 were populated in the Ca-40(Si-28,4p) reaction at a beam energy of 122 MeV. Evaporated, light, charged particles were identified by the Microball, while gamma rays were detected using the Gammasphere array. The main focus of this paper is on two strongly coupled, collective bands. The yrast band, which was previously known, has been linked to lower-lying states establishing the excitation energies and angular momenta of in-band states for the first time. The newly identified excited band decays to the yrast band but firm angular-momentum assignments could not be made. In order to interpret these structures cranked-Nilsson-Strutinsky calculations have been performed. The calculations have been extended to account for the distribution of nucleons within a configuration. The yrast collective band is interpreted as based on the pi(f(7/2))(-1)(p(3/2)f(5/2))(2)(g(9/2))(1)nu(p(3/2)f(5/2))(4)(g(9/2))(2) configuration. There are several possible interpretations of the second band but it is difficult to distinguish between the different possibilities.
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| 9. |
- Klamer, Daniel, 1976, et al.
(författare)
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Habituation of acoustic startle is disrupted by psychotomimetic drugs: differential dependence on dopaminergic and nitric oxide modulatory mechanisms
- 2004
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Ingår i: Psychopharmacology (Berl). ; 176:3-4, s. 440-50
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Tidskriftsartikel (refereegranskat)abstract
- RATIONALE: A deficit in attention and information processing has been considered a central feature in schizophrenia, which might lead to stimulus overload and cognitive fragmentation. It has been shown that patients with schizophrenia display a relative inability to gate incoming stimuli. Thus, patients repeatedly subjected to acoustic startle-eliciting stimuli habituate less to these stimuli than controls. Furthermore, schizophrenia-like symptoms can be induced by pharmacological manipulations in humans by psychotomimetic drugs, e.g. phencyclidine (PCP) and D-amphetamine (D-AMP). Recent studies show that the behavioural and biochemical effects of PCP in rodents are blocked by nitric oxide synthase (NOS) inhibitors, suggesting that NO plays an important role in at least the pharmacological effects of PCP. OBJECTIVES: The first aim of the present study was to investigate if PCP, MK-801 and D-AMP impair habituation of acoustic startle in mice. Secondly, we examine the effect of the NOS inhibitor, L-NAME, and the dopamine receptor antagonist, haloperidol, on drug-induced deficit in habituation. RESULTS: PCP (4 mg/kg), MK-801 (0.4 mg/kg) and D-AMP (5.0 mg/kg), impaired habituation of the acoustic startle response in mice. This effect was reversed by the NOS inhibitor, L-NAME. The typical antipsychotic, haloperidol, reversed the effects of PCP and D-AMP, but not that of MK-801. CONCLUSIONS: The finding that PCP, MK-801 and D-AMP impair habituation in mice is consistent with the idea that these treatments model certain filter deficits seen in schizophrenic patients. Furthermore, the present results suggest that NO is critically involved in these effects on habituation, whereas that of dopamine is less clear.
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| 10. |
- Klamer, Daniel, 1976, et al.
(författare)
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Phencyclidine-induced behaviour in mice prevented by methylene blue
- 2004
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Ingår i: Basic & Clinical Pharmacology & Toxicology. - 1742-7835. ; 94:2, s. 65-72
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Tidskriftsartikel (refereegranskat)abstract
- Schizophrenia is a major public health problem that affects approximately 1% of the population worldwide. Schizophrenia-like symptoms can be induced in humans by phencyclidine (PCP), a drug with marked psychotomimetic properties. Phencyclidine disrupts prepulse inhibition of acoustic startle in rodents, a measure which has also been shown to be disrupted in schizophrenic patients. This effect is blocked by nitric oxide synthase (NOS) inhibitors, suggesting that nitric oxide plays an important role in this effect of phencyclidine. Methylene blue, a guanylate cyclase and nitric oxide syntase inhibitor, has shown therapeutic value as an adjuvant to conventional antipsychotics in the therapy of schizophrenia. The aim of the present study was to investigate if phencyclidine-(4 mg/kg)induced disruption of prepulse inhibition could be affected by methylene blue (50 or 100 mg/kg) in mice. Furthermore, the effect of methylene blue (50 mg/kg) on phencyclidine-(4 mg/kg)induced hyperlocomotion was investigated. The present study shows that phencyclidine readily disrupts prepulse inhibition in mice without affecting pulse-alone trials. It was also found that methylene blue prevents the decrease in prepulse inhibition caused by phencyclidine in a dose-related manner. Furthermore, the increase in locomotor activity caused by phencyclidine was reduced by pretreatment with methylene blue. The results from the present study further support the suggestion that the nitric oxide synthase/guanylate cyclase pathway is involved in pharmacological and behavioural effects of phencyclidine. Since phencyclidine as well exerts psychotomimetic characteristics, agents that interfere with the nitric oxide synthase/guanylate cyclase pathway may be of therapeutic value also in the treatment of schizophrenia.
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