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Sökning: WFRF:(Svensson Olof) > (2010-2013)

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61.
  • Åberg, Jonas, et al. (författare)
  • Calcium sulphate spinal cord scaffold : a study on degradation and fibroblast growth factor 1 loading and release
  • 2012
  • Ingår i: Journal of biomaterials applications. - : SAGE Publications. - 0885-3282 .- 1530-8022. ; 26:6, s. 667-685
  • Tidskriftsartikel (refereegranskat)abstract
    • Currently, there is no regenerative strategy for the spinal cord that is part of clinical standard of core. Current paths usually include combinations of scaffold materials and active molecules. In a recent study, a permanent dental resin scaffold for treatment of spinal cord injury was designed. The results from studies on rats were promising. However, for potential clinical use, a biodegradable scaffold material that facilitates drug delivery and the regeneration of the spinal cord needs to be developed. Also a biodegradable material is expected to allow a better evaluation of the efficacy of the surgical method. In this article, the suitability of hardened calcium sulfate cement (CSC) for use as degradable spinal cord scaffolds is investigated in bench studies and in vitro studies. Compressive strength, degradation and microstructure, and the loading capability of heparin-activated fibroblast growth factor 1 (FGF1) via soaking were evaluated. The CSC could easily be injected into the scaffold mold and the obtained scaffolds had sufficient strength to endure the loads applied during surgery. When hardened, the CSC formed a porous microstructure suitable for loading of active substances. It was shown that 10 min of FGF1 soaking was enough to obtain a sustained active FGF1 release for 20–35 days. The results showed that CSC is a promising material for spinal cord scaffold fabrication, since it is biodegradable, has sufficient strength, and allows loading and controlled release of active FGF1.
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62.
  • Öberg, Martin, et al. (författare)
  • A comparison of digital morphometry and clinical measurements of ears.
  • 2013
  • Ingår i: Journal of Plastic Surgery and Hand Surgery. - 2000-656X. ; 47:4, s. 317-319
  • Tidskriftsartikel (refereegranskat)abstract
    • Abstract Clinical measurements are necessary in many routine follow-ups and scientific evaluations, but the accuracy of these measurements is seldom challenged. The size of the reconstructed ear is one important parameter in the follow-up regarding patients operated on due to microtia. With the introduction of digital morphometry one was obliged to evaluate its accuracy in comparison to its analogue equivalents. In a first series of measurements the ears of 30 persons were assessed using digital morphometry, compass and ruler, and calliper to test the accuracy of these methods. In a second series of measurements, 10 patients with reconstructed unilateral microtia were assessed with digital morphometry to test the inter-individual variation of this method. The accuracy of digital morphometry was of the same magnitude as the manual methods. When the inter-individual variation of accuracy was assessed in digital morphometry it was found that random error differed from person to person. In scientific settings, for instance when evaluating possible growth of the cartilage framework, the specific individual accuracy must therefore be taken into account in order to draw safe conclusions.
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63.
  • Öberg, Martin, et al. (författare)
  • Threshold of tactile perception in a reconstructed auricle.
  • 2011
  • Ingår i: Journal of Plastic Surgery and Hand Surgery. - 2000-656X. ; 45:1, s. 23-27
  • Tidskriftsartikel (refereegranskat)abstract
    • Abstract There are more important outcome variables than the aesthetic when it comes to a successful result in reconstruction of the ear for microtia. The protective sensitivity, for example, is important to avoid damage to the skin covering the cartilaginous framework. We studied 39 patients with unilateral microtia and recorded their skin sensitivity more than six months after the last operation. The Semmes-Weinstein Monofilament Test (SWMT) was used to assess the threshold of protective sensitivity in three particular areas: the helix, the anthelix, and the lobule. The opposite ear served as control. A monofilament of 4.31 or less was regarded as acceptable protective sensitivity. Thirty-two patients had acceptable sensitivity in the whole ear, but the helix gave a poor result in seven patients and in one of them so did the anthelix.
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