| 61. |
- Wei, Jiang, et al.
(författare)
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Estrogen upregulates hepatic apolipoprotein M expression via the estrogen receptor
- 2011
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Ingår i: Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids. - : Elsevier BV. - 1388-1981. ; 1811:12, s. 1146-1151
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Tidskriftsartikel (refereegranskat)abstract
- Apolipoprotein M (apoM) is present predominantly in high-density lipoprotein (HDL) in human plasma, thus possibly involved in the regulation of HDL metabolism and the process of atherosclerosis. Although estrogen replacement therapy increases serum levels of apoAl and HDL, it does not seem to reduce the cardiovascular risk in postmenopausal women. Therefore, we investigated the effects of estrogen on apoM expression in vitro and in vivo. HepG2 cells were incubated with different concentrations of estrogen with or without the estrogen receptor antagonist, fulvestrant, and apoM expression in the cells was determined. Hepatic apoM expression and serum levels of apoM were also determined in normal and in ovariectomized rats treated with either placebo or estradiol benzoate, using sham operated rats as controls. Estrogen significantly increased mRNA levels of apoM and apoAl in HepG2 cell cultures in a dose- and time-dependent manner; the upregulation of both apolipoproteins was fully abolished by addition of estrogen receptor antagonist In normal rats, estrogen treatment led to an increase in plasma lipid levels including HDL cholesterol, a marked upregulation of apoM mRNA and a significant increase in serum levels of apoM. The same pattern of regulation was found in ovariectomized rats treated with estrogen. Thus, estrogen upregulates apoM expression both in vivo and in vitro by mechanism(s) involving the estrogen receptor. (C) 2011 Elsevier B.V. All rights reserved.
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| 62. |
- Wei, Shuoguo, et al.
(författare)
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Refund polices for core collecting regarding the customers’ responses
- 2014
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Annan publikation (övrigt vetenskapligt/konstnärligt)abstract
- To encourage the return of cores, remanufacturers in practice commonly charge a certain amount of purchasing deposit, and refund it to the customer based on the result of quality inspection in the return process. Two types of classification errors exist and interact with each other during such an inspection process: either low quality cores are defined as remanufacturable; or high quality cores are defined non-remanufacturable. A remanufacturer has to choose a combination them and determine a proper deposit value, with the consideration of customers’ possible responses concerning purchasing and return behaviors. Within a game theory framework, the analytical solutions of these issues are firstly developed under the assumption that the customer has the inspection error information. When this information is not available, the solutions are analyzed with a given and fixed deposit. The value of information transparency in inspection errors is shown by comparing these two settings. The salvage value of different cores also has a great influence on the remanufacturer’s profit. In addition, the effect of conservatively estimating customers’ product payoff and the influences of improving inspection accuracy are investigated numerically. Interestingly, the customer may return more low quality cores when the inspection accuracy is improved.
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| 63. |
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| 64. |
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| 65. |
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| 66. |
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| 67. |
- Yuan, Xiaoming, et al.
(författare)
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A new approach to establish both stable and metastable phase equilibria for fcc ordered/disordered phase transition : application to the Al-Ni and Ni-Si systems
- 2012
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Ingår i: Materials Chemistry and Physics. - : Elsevier BV. - 0254-0584 .- 1879-3312. ; 135:1, s. 94-105
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Tidskriftsartikel (refereegranskat)abstract
- Both two-sublattice (2SL) and four-sublattice (4SL) models in the framework of the compound energy formalism can be used to describe the fcc ordered/disordered transitions. When transferring the parameters of 2SL disregarding the metastable ordered states into those of 4SL, inconsistence in either stable or metastable phase diagrams could appear, as detected in both Al-Ni and Ni-Si systems. To avoid such a kind of drawback, this behavior was analyzed and investigated in the Ni-Si and Al-Ni systems with the aid of first principle calculations. Furthermore, a new approach considering both the stable and metastable fcc ordered phase equilibria deduced from the first principles calculations was proposed to perform a reliable thermodynamic modeling for the fcc ordered/disordered transition. The Ni-Si system was then thermodynamically assessed using the presently proposed approach. The good agreement between the calculation and experiments demonstrates the reliability of the proposed approach. It is expected that the approach is valid for other systems showing complex ordered/disordered transitions.
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| 68. |
- Zhang, S. N., et al.
(författare)
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The high energy cosmic-radiation detection (HERD) facility onboard China's Space Station
- 2014
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Ingår i: Proceedings of SPIE - The International Society for Optical Engineering. - : SPIE. - 9780819496126
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Konferensbidrag (refereegranskat)abstract
- The High Energy cosmic-Radiation Detection (HERD) facility is one of several space astronomy payloads of the cosmic lighthouse program onboard China's Space Station, which is planned for operation starting around 2020 for about 10 years. The main scientific objectives of HERD are indirect dark matter search, precise cosmic ray spectrum and composition measurements up to the knee energy, and high energy gamma-ray monitoring and survey. HERD is composed of a 3-D cubic calorimeter (CALO) surrounded by microstrip silicon trackers (STKs) from five sides except the bottom. CALO is made of about 104 cubes of LYSO crystals, corresponding to about 55 radiation lengths and 3 nuclear interaction lengths, respectively. The top STK microstrips of seven X-Y layers are sandwiched with tungsten converters to make precise directional measurements of incoming electrons and gamma-rays. In the baseline design, each of the four side SKTs is made of only three layers microstrips. All STKs will also be used for measuring the charge and incoming directions of cosmic rays, as well as identifying back scattered tracks. With this design, HERD can achieve the following performance: energy resolution of 1% for electrons and gamma-rays beyond 100 GeV, 20% for protons from 100 GeV to 1 PeV; electron/proton separation power better than 10-5; effective geometrical factors of >3 m2sr for electron and diffuse gamma-rays, >2 m2sr for cosmic ray nuclei. R and D is under way for reading out the LYSO signals with optical fiber coupled to image intensified CCD and the prototype of one layer of CALO.
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