| 1. |
- Lundmark, Jöns, et al.
(författare)
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Paroxetine : pharmacokinetic and antidepressant effect in the elderly
- 1989
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Ingår i: Acta Psychiatrica Scandinavica. - : Wiley. - 0001-690X .- 1600-0447. ; 80:S350, s. 76-80
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Tidskriftsartikel (refereegranskat)abstract
- To evaluate the pharmacokinetic properties, efficacy, and tolerability of paroxetine in elderly depressed patients, a clinical study was set up - initially at Aalborg Psychiatric Hospital in Denmark, and subsequently at the University Hospital in Linköping, Sweden. A total of 21 patients with a median age of 72 years were included in the study. After a single dose of 20 or 30mg of paroxetine followed by two drug-free days, treatment continued with 20 or 30mg daily for seven weeks. The majority of patients showed a continuous reduction in their HAMD scores, starting in the second week of treatment. Paroxetine was well tolerated at the doses given, and side-effects were mostly mild and transient. Steady-state, pre-dose plasma levels of paroxetine showed considerable variability, and the median steady-state concentration was higher in elderly patients compared with data from a previous study in young volunteers. Elimination half-lives also showed variability between these elderly patients, but tended to be longer after cessation of multiple dosing than after a single dose. They also tended to be longer than in the young volunteers. The results of this study do not advocate reduced doses of paroxetine in the elderly, but further studies are warranted.
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| 2. |
- Alder, V A, et al.
(författare)
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Macro- and micrograzing effects on phytoplankton communities
- 1989
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Ingår i: The expedition Antarktis VII/3 (EPOS LEG 2) of RV "Polarstern" in 1988/89. - Bremerhaven : Alfred- Wegener-Institut für Polar Meeresforschung. ; , s. 123-130
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Bokkapitel (övrigt vetenskapligt/konstnärligt)
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| 3. |
- Hertz, H.M., et al.
(författare)
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High voltage measurement system based on a capacitively coupled Pockels cell
- 1987
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Ingår i: Proc. SPIE - Int. Soc. Opt. Eng. (USA). ; 701, s. 8-226
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Konferensbidrag (övrigt vetenskapligt/konstnärligt)abstract
- A fiber-optical system for measurements of fast high voltage pulses has been developed. The system is based on capacitively coupled Pockels cell voltage sensor and features excellent rejection of electrical interference, large bandwidth and practically unlimited voltage range. The authors describe the principle of operation and give a preliminary discussion of the performance of the measurement system
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| 4. |
- Thomsen, P, et al.
(författare)
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Acute synovitis induced by preformed immune complexes
- 1986
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Ingår i: Scandinavian Journal of Rheumatology. - : Informa UK Limited. - 1502-7732 .- 0300-9742. ; 15:2, s. 134-142
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Tidskriftsartikel (refereegranskat)abstract
- The morphology of acute immune complex (IC) elicited synovitis in rabbit knee joints was studied, as well as IC-induced leukocyte activation in vivo and in vitro. Acute synovitis was induced by intra-articular injection of in vitro preformed, complement activating bovine serum albumin (BSA)-anti-BSA IC. Within 30 min, migration of polymorphonuclear granulocytes (PMNGs) was observed. Scanning electron microscopy showed that adhering, apparently activated leukocytes were attached to the synovial lining, often forming clusters. Phagocytosis of IC was evident, as immunoglobulins were detected within the leukocyte cytoplasm by the direct immunofluorescence technique. At the peak accumulation of PMNGs, focal erosions of the synovial lining were observed. Later, monocytes and macrophages appeared and degenerated PMNGs were found, sometimes within the cytoplasm of large macrophages. Chemiluminescence experiments showed a maximum in vitro activation of leukocytes by complement activating IC formed near optimal precipitation proportions and in slight antigen excess, whereas IC in large antigen excess gave a smaller and later response.
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