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The scaffold protein p140Cap limits ERBB2-mediated breast cancer progression interfering with Rac GTPase-controlled circuitries

Grasso, Silvia (author)
University of Turin
Chapelle, Jennifer (author)
University of Turin
Salemme, Vincenzo (author)
University of Turin
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Aramu, Simona (author)
University of Turin
Russo, Isabella (author)
University of Turin
Vitale, Nicoletta (author)
University of Turin
Verdun di Cantogno, Ludovica (author)
University of Turin
Dallaglio, Katiuscia (author)
Arcispedale Santa Maria Nuova
Castellano, Isabella (author)
University of Turin
Amici, Augusto (author)
University of Camerino
Centonze, Giorgia (author)
University of Turin
Sharma, Nanaocha (author)
University of Turin
Lunardi, Serena (author)
University of Turin
Cabodi, Sara (author)
University of Turin
Cavallo, Federica (author)
University of Turin
Lamolinara, Alessia (author)
University G.d'Annunzio of Chieti-Pescara
Stramucci, Lorenzo (author)
University G.d'Annunzio of Chieti-Pescara
Moiso, Enrico (author)
University of Turin
Provero, Paolo (author)
University of Turin
Albini, Adriana (author)
IRCCS Multimedica
Sapino, Anna (author)
University of Turin
Staaf, Johan (author)
Lund University,Lunds universitet,Bröstcancer-genetik,Sektion I,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Breastcancer-genetics,Section I,Department of Clinical Sciences, Lund,Faculty of Medicine
Di Fiore, Pier Paolo (author)
University of Milan
Bertalot, Giovanni (author)
European Institute of Oncology
Pece, Salvatore (author)
University of Milan
Tosoni, Daniela (author)
European Institute of Oncology
Confalonieri, Stefano (author)
IFOM - The FIRC Institute of Molecular Oncology
Iezzi, Manuela (author)
University G.d'Annunzio of Chieti-Pescara
Di Stefano, Paola (author)
University of Turin
Turco, Emilia (author)
University of Turin
Defilippi, Paola (author)
University of Turin
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 (creator_code:org_t)
2017-03-16
2017
English.
In: Nature Communications. - : Springer Science and Business Media LLC. - 2041-1723. ; 8
Related links:
http://dx.doi.org/10... (free)
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https://www.nature.c...
https://lup.lub.lu.s...
https://doi.org/10.1...
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  • Journal article (peer-reviewed)
Abstract Subject headings
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  • The docking protein p140Cap negatively regulates tumour cell features. Its relevance on breast cancer patient survival, as well as its ability to counteract relevant cancer signalling pathways, are not fully understood. Here we report that in patients with ERBB2-amplified breast cancer, a p140Cap-positive status associates with a significantly lower probability of developing a distant event, and a clear difference in survival. p140Cap dampens ERBB2-positive tumour cell progression, impairing tumour onset and growth in the NeuT mouse model, and counteracting epithelial mesenchymal transition, resulting in decreased metastasis formation. One major mechanism is the ability of p140Cap to interfere with ERBB2-dependent activation of Rac GTPase-controlled circuitries. Our findings point to a specific role of p140Cap in curbing the aggressiveness of ERBB2-amplified breast cancers and suggest that, due to its ability to impinge on specific molecular pathways, p140Cap may represent a predictive biomarker of response to targeted anti-ERBB2 therapies.

Subject headings

MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- Cancer and Oncology (hsv//eng)

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Journal Article

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