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Träfflista för sökning "WFRF:(Turesson I) ;lar1:(lu);srt2:(1976-1979)"

Search: WFRF:(Turesson I) > Lund University > (1976-1979)

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1.
  • Pearlstein, E, et al. (author)
  • Expression of protein HC on the plasma membrane of different human cell types
  • 1977
  • In: Journal of immunology. - 0022-1767. ; 119:3, s. 9-824
  • Journal article (peer-reviewed)abstract
    • The surface expression of a recently described plasma glycoprotein called human complex-forming glycoprotein, hetergeneous in charge (protein HC) on a number of different human cell types was investigated. By means of direct and indirect immunofluorescence, protein HC was shown to be associated with the surface of virtually all cells of the investigated normal cell types including erythrocytes, peripheral blood B and T lymphocytes, and the human fibroblast lines HE 81, HE 31, and WI 38. When transformed and malignant cell populations were studied, it was found that some populations (e.g., the T cell line Molt-4) carried protein HC on the surfaces of very few cells, whereas other cell populations (e.g., chronic lymphocytic leukemia lymphocytes) carried the protein on most cells. Malignant cell populations with intermediary percentages of protein HC-positive cells were also found. Protein HC on the cell surface of normal peripheral blood lymphocytes could be redistributed by incubation of the cells with anti-protein HC-antiserum at 37 degrees C, and this reaction could be inhibited by sodium azide.
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2.
  • Tejler, L, et al. (author)
  • Immunofluorescent demonstration of the presence of protein HC on the surface of human lymphocytes
  • 1976
  • In: Acta Medica Scandinavica. - : Wiley. - 0001-6101. ; 199:5, s. 7-425
  • Journal article (peer-reviewed)abstract
    • Indirect immunofluorescence was used to demonstrate the presence of protein HC on the surface of a large percentage of normal human peripheral blood lymphocytes. Protein HC is a recently described charge heterogeneous, complex-forming glycoprotein normally present in human plasma, urine and cerebrospinal fluid. The synthesis of protein HC by lymphocytes was indicated by the removal of the glycoprotein from the cell surfaces on trypsinization of the cells followed by the reappearance of the protein on continued cultivation of the cells.
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3.
  • Turesson, I, et al. (author)
  • Non-secretory or low-secretory myeloma with intracellular kappa chains. Report of six cases and review of the literature
  • 1978
  • In: Acta Medica Scandinavica. - : Wiley. - 0001-6101. ; 204:6, s. 51-445
  • Journal article (peer-reviewed)abstract
    • This report concerns six cases of multiple myeloma characterized by either no demonstrable monoclonal immunoglobulin in plasma or urine or by trace amounts (less than or equal to 0.1 g/l) of monoclonal kappa chains in the urine. In all cases there was an infiltration of the bone marrow by plasma cells containing kappa chains but no heavy chains. A retrospective analysis was made of 126 consecutive cases of Bence Jones myeloma. The number of kappa and lambda cases was approximately the same. All cases secreting less than or equal to 0.1 g light chains per 1 urine were of kappa type. This contrasts with a kappa/lambda ratio of 1.4-1.9 among reported series of M-components containing both heavy and light chains. A review of reported cases of non-secretory myeloma revealed a preserved capacity for Ig synthesis in the majority of cases and among these a preponderance of kappa chain producing clones. These observations might be explained by a higher tendency for kappa chain producing cells to mutate to low secretors or to cells producing abnormal light chains which are catabolized rapidly. The clinical data from our patients do not indicate a more pessimistic prognosis in non- or low-secretory myeloma, than in other cases of multiple myeloma.
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  • Result 1-3 of 3
Type of publication
journal article (3)
Type of content
peer-reviewed (3)
Author/Editor
Turesson, I (3)
Tejler, L (2)
Grubb, A O (2)
Grubb, A (1)
Pearlstein, E (1)
University
Lund University  (3)Undo refine
Language
English (3)
Research subject (UKÄ/SCB)
Medical and Health Sciences (1)

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