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Non-Cholesterol Ste...
Non-Cholesterol Sterol Levels Predict Hyperglycemia and Conversion to Type 2 Diabetes in Finnish Men
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Cederberg, H. (author)
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Gylling, H. (author)
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Miettinen, T. A. (author)
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Paananen, J. (author)
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Vangipurapu, J. (author)
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Pihlajamaki, J. (author)
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Kuulasmaa, T. (author)
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Stancakova, A. (author)
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- Smith, Ulf, 1943 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för molekylär och klinisk medicin,Institute of Medicine, Department of Molecular and Clinical Medicine
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Kuusisto, J. (author)
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Laakso, M. (author)
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(creator_code:org_t)
- 2013-06-28
- 2013
- English.
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In: Plos One. - : Public Library of Science (PLoS). - 1932-6203. ; 8:6
- Related links:
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https://gup.ub.gu.se...
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https://doi.org/10.1...
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Abstract
Subject headings
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- We investigated the levels of non-cholesterol sterols as predictors for the development of hyperglycemia (an increase in the glucose area under the curve in an oral glucose tolerance test) and incident type 2 diabetes in a 5-year follow-up study of a population-based cohort of Finnish men (METSIM Study, N = 1,050) having non-cholesterol sterols measured at baseline. Additionally we determined the association of 538,265 single nucleotide polymorphisms (SNP) with non-cholesterol sterol levels in a cross-sectional cohort of non-diabetic offspring of type 2 diabetes (the Kuopio cohort of the EUGENE2 Study, N = 273). We found that in a cross-sectional METSIM Study the levels of sterols indicating cholesterol absorption were reduced as a function of increasing fasting glucose levels, whereas the levels of sterols indicating cholesterol synthesis were increased as a function of increasing 2-hour glucose levels. A cholesterol synthesis marker desmosterol significantly predicted an increase, and two absorption markers (campesterol and avenasterol) a decrease in the risk of hyperglycemia and incident type 2 diabetes in a 5-year follow-up of the METSIM cohort, mainly attributable to insulin sensitivity. A SNP of ABCG8 was associated with fasting plasma glucose levels in a cross-sectional study but did not predict hyperglycemia or incident type 2 diabetes. In conclusion, the levels of some, but not all non-cholesterol sterols are markers of the worsening of hyperglycemia and type 2 diabetes.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Endokrinologi och diabetes (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Endocrinology and Diabetes (hsv//eng)
Keyword
- impaired glucose-tolerance
- insulin sensitivity
- absorption
- metabolism
- association
- obesity
- abcg8
- dyslipidemia
- secretion
- diagnosis
Publication and Content Type
- ref (subject category)
- art (subject category)
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Plos One
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To the university's database
- By the author/editor
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Cederberg, H.
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Gylling, H.
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Miettinen, T. A.
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Paananen, J.
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Vangipurapu, J.
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Pihlajamaki, J.
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show more...
-
Kuulasmaa, T.
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Stancakova, A.
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Smith, Ulf, 1943
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Kuusisto, J.
-
Laakso, M.
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show less...
- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Endocrinology an ...
- Articles in the publication
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Plos One
- By the university
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University of Gothenburg