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Genetic analysis of over 1 million people identifies 535 new loci associated with blood pressure traits.

Evangelou, Evangelos (author)
Imperial College London,University of Ioannina
Warren, Helen R (author)
Mosen-Ansorena, David (author)
show more...
Mifsud, Borbala (author)
Pazoki, Raha (author)
Gao, He (author)
Ntritsos, Georgios (author)
Dimou, Niki (author)
Cabrera, Claudia P (author)
Karaman, Ibrahim (author)
Ng, Fu Liang (author)
Evangelou, Marina (author)
Witkowska, Katarzyna (author)
Tzanis, Evan (author)
Hellwege, Jacklyn N (author)
Giri, Ayush (author)
Velez Edwards, Digna R (author)
Sun, Yan V (author)
Cho, Kelly (author)
Gaziano, J Michael (author)
Wilson, Peter W F (author)
Tsao, Philip S (author)
Kovesdy, Csaba P (author)
Esko, Tonu (author)
Mägi, Reedik (author)
Milani, Lili (author)
Almgren, Peter (author)
Lund University,Lunds universitet,Kardiovaskulär forskning - hypertoni,Forskargrupper vid Lunds universitet,Cardiovascular Research - Hypertension,Lund University Research Groups
Boutin, Thibaud (author)
Debette, Stéphanie (author)
Ding, Jun (author)
Giulianini, Franco (author)
Holliday, Elizabeth G (author)
Jackson, Anne U (author)
Li-Gao, Ruifang (author)
Lin, Wei-Yu (author)
Luan, Jian'an (author)
Mangino, Massimo (author)
Oldmeadow, Christopher (author)
Prins, Bram Peter (author)
Qian, Yong (author)
Sargurupremraj, Muralidharan (author)
Shah, Nabi (author)
Surendran, Praveen (author)
Thériault, Sébastien (author)
Verweij, Niek (author)
Willems, Sara M (author)
Zhao, Jing-Hua (author)
Amouyel, Philippe (author)
Connell, John (author)
de Mutsert, Renée (author)
Doney, Alex S F (author)
Farrall, Martin (author)
Menni, Cristina (author)
Morris, Andrew D (author)
Noordam, Raymond (author)
Paré, Guillaume (author)
Poulter, Neil R (author)
Shields, Denis C (author)
Stanton, Alice (author)
Thom, Simon (author)
Abecasis, Gonçalo (author)
Amin, Najaf (author)
Arking, Dan E (author)
Lind, Lars (author)
Uppsala universitet,Kardiovaskulär epidemiologi
Barbieri, Caterina M (author)
Batini, Chiara (author)
Bis, Joshua C (author)
Blake, Tineka (author)
Bochud, Murielle (author)
Boehnke, Michael (author)
Boerwinkle, Eric (author)
Boomsma, Dorret I (author)
Bottinger, Erwin P (author)
Braund, Peter S (author)
Brumat, Marco (author)
Campbell, Archie (author)
Campbell, Harry (author)
Chakravarti, Aravinda (author)
Chambers, John C (author)
Chauhan, Ganesh (author)
Ciullo, Marina (author)
Cocca, Massimiliano (author)
Collins, Francis (author)
Cordell, Heather J (author)
Davies, Gail (author)
de Borst, Martin H (author)
de Geus, Eco J (author)
Deary, Ian J (author)
Deelen, Joris (author)
Del Greco M, Fabiola (author)
Demirkale, Cumhur Yusuf (author)
Dörr, Marcus (author)
Ehret, Georg B (author)
Elosua, Roberto (author)
Enroth, Stefan, 1976- (author)
Uppsala universitet,Science for Life Laboratory, SciLifeLab,Institutionen för immunologi, genetik och patologi
Erzurumluoglu, A Mesut (author)
Ferreira, Teresa (author)
Frånberg, Mattias (author)
Stockholms universitet,Matematiska institutionen,Karolinska Institutet, Sweden
Franco, Oscar H (author)
Gandin, Ilaria (author)
Gasparini, Paolo (author)
Giedraitis, Vilmantas (author)
Uppsala universitet,Geriatrik
Gieger, Christian (author)
Girotto, Giorgia (author)
Goel, Anuj (author)
Gow, Alan J (author)
Gudnason, Vilmundur (author)
Guo, Xiuqing (author)
Gyllensten, Ulf B. (author)
Uppsala universitet,Institutionen för immunologi, genetik och patologi,Science for Life Laboratory, SciLifeLab
Hamsten, Anders (author)
Karolinska Institutet
Harris, Tamara B (author)
Harris, Sarah E (author)
Hartman, Catharina A (author)
Havulinna, Aki S (author)
Hicks, Andrew A (author)
Hofer, Edith (author)
Hofman, Albert (author)
Hottenga, Jouke-Jan (author)
Huffman, Jennifer E (author)
Hwang, Shih-Jen (author)
Ingelsson, Erik, 1975- (author)
Uppsala universitet,Science for Life Laboratory, SciLifeLab,Molekylär epidemiologi
James, Alan (author)
Jansen, Rick (author)
Karolinska Institutet
Jarvelin, Marjo-Riitta (author)
Joehanes, Roby (author)
Johansson, Åsa (author)
Uppsala universitet,Institutionen för immunologi, genetik och patologi,Science for Life Laboratory, SciLifeLab
Johnson, Andrew D (author)
Joshi, Peter K (author)
Jousilahti, Pekka (author)
Jukema, J Wouter (author)
Jula, Antti (author)
Kähönen, Mika (author)
Kathiresan, Sekar (author)
Keavney, Bernard D (author)
Khaw, Kay-Tee (author)
Knekt, Paul (author)
Knight, Joanne (author)
Kolcic, Ivana (author)
Kooner, Jaspal S (author)
Koskinen, Seppo (author)
Kristiansson, Kati (author)
Kutalik, Zoltan (author)
Laan, Maris (author)
Larson, Marty (author)
Launer, Lenore J (author)
Lehne, Benjamin (author)
Lehtimäki, Terho (author)
Liewald, David C M (author)
Lin, Li (author)
Lind, Lars (author)
Uppsala universitet,Kardiovaskulär epidemiologi
Lindgren, Cecilia M (author)
Liu, YongMei (author)
Loos, Ruth J F (author)
Lopez, Lorna M (author)
Lu, Yingchang (author)
Lyytikäinen, Leo-Pekka (author)
Mahajan, Anubha (author)
Mamasoula, Chrysovalanto (author)
Marrugat, Jaume (author)
Marten, Jonathan (author)
Milaneschi, Yuri (author)
Morgan, Anna (author)
Morris, Andrew P (author)
Morrison, Alanna C (author)
Munson, Peter J (author)
Nalls, Mike A (author)
Nandakumar, Priyanka (author)
Nelson, Christopher P (author)
Niiranen, Teemu (author)
Nolte, Ilja M (author)
Nutile, Teresa (author)
Oldehinkel, Albertine J (author)
Oostra, Ben A (author)
O'Reilly, Paul F (author)
Org, Elin (author)
Padmanabhan, Sandosh (author)
Palmas, Walter (author)
Palotie, Aarno (author)
Pattie, Alison (author)
Penninx, Brenda W J H (author)
Perola, Markus (author)
Peters, Annette (author)
Polasek, Ozren (author)
Pramstaller, Peter P (author)
Nguyen, Quang Tri (author)
Raitakari, Olli T (author)
Ren, Meixia (author)
Rettig, Rainer (author)
Rice, Kenneth (author)
Ridker, Paul M (author)
Ried, Janina S (author)
Riese, Harriëtte (author)
Ripatti, Samuli (author)
Robino, Antonietta (author)
Rose, Lynda M (author)
Rotter, Jerome I (author)
Rudan, Igor (author)
Ruggiero, Daniela (author)
Saba, Yasaman (author)
Sala, Cinzia F (author)
Salomaa, Veikko (author)
Samani, Nilesh J (author)
Sarin, Antti-Pekka (author)
Schmidt, Reinhold (author)
Schmidt, Helena (author)
Shrine, Nick (author)
Siscovick, David (author)
Smith, Albert V (author)
Snieder, Harold (author)
Sõber, Siim (author)
Sorice, Rossella (author)
Starr, John M (author)
Stott, David J (author)
Strachan, David P (author)
Strawbridge, Rona J (author)
Sundström, Johan, Professor, 1971- (author)
Uppsala universitet,Kardiovaskulär epidemiologi
Swertz, Morris A (author)
Taylor, Kent D (author)
Teumer, Alexander (author)
Tobin, Martin D (author)
Tomaszewski, Maciej (author)
Toniolo, Daniela (author)
Traglia, Michela (author)
Trompet, Stella (author)
Tuomilehto, Jaakko (author)
Tzourio, Christophe (author)
Uitterlinden, André G (author)
Vaez, Ahmad (author)
van der Most, Peter J (author)
van Duijn, Cornelia M (author)
Vergnaud, Anne-Claire (author)
Verwoert, Germaine C (author)
Vitart, Veronique (author)
Völker, Uwe (author)
Vollenweider, Peter (author)
Vuckovic, Dragana (author)
Watkins, Hugh (author)
Wild, Sarah H (author)
Willemsen, Gonneke (author)
Wilson, James F (author)
Wright, Alan F (author)
Yao, Jie (author)
Zemunik, Tatijana (author)
Zhang, Weihua (author)
Attia, John R (author)
Butterworth, Adam S (author)
Chasman, Daniel I (author)
Conen, David (author)
Cucca, Francesco (author)
Danesh, John (author)
Hayward, Caroline (author)
Howson, Joanna M M (author)
Laakso, Markku (author)
Lakatta, Edward G (author)
Langenberg, Claudia (author)
Melander, Olle (author)
Lund University,Lunds universitet,Kardiovaskulär forskning - hypertoni,Forskargrupper vid Lunds universitet,Cardiovascular Research - Hypertension,Lund University Research Groups
Mook-Kanamori, Dennis O (author)
Palmer, Colin N A (author)
Risch, Lorenz (author)
Scott, Robert A (author)
Scott, Rodney J (author)
Sever, Peter (author)
Spector, Tim D (author)
van der Harst, Pim (author)
Wareham, Nicholas J (author)
Zeggini, Eleftheria (author)
Levy, Daniel (author)
Munroe, Patricia B (author)
Newton-Cheh, Christopher (author)
Brown, Morris J (author)
Metspalu, Andres (author)
Hung, Adriana M (author)
O'Donnell, Christopher J (author)
Edwards, Todd L (author)
Psaty, Bruce M (author)
Tzoulaki, Ioanna (author)
Barnes, Michael R (author)
Wain, Louise V (author)
Elliott, Paul (author)
Imperial College London
Caulfield, Mark J (author)
Queen Mary University
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 (creator_code:org_t)
 
2018-09-17
2018
English.
In: Nature Genetics. - : Springer Science and Business Media LLC. - 1061-4036 .- 1546-1718. ; 50:10, s. 1412-1425
  • Journal article (peer-reviewed)
Abstract Subject headings
Close  
  • High blood pressure is a highly heritable and modifiable risk factor for cardiovascular disease. We report the largest genetic association study of blood pressure traits (systolic, diastolic and pulse pressure) to date in over 1 million people of European ancestry. We identify 535 novel blood pressure loci that not only offer new biological insights into blood pressure regulation but also highlight shared genetic architecture between blood pressure and lifestyle exposures. Our findings identify new biological pathways for blood pressure regulation with potential for improved cardiovascular disease prevention in the future.

Subject headings

MEDICIN OCH HÄLSOVETENSKAP  -- Medicinska och farmaceutiska grundvetenskaper -- Medicinsk genetik (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Basic Medicine -- Medical Genetics (hsv//eng)
NATURVETENSKAP  -- Biologi (hsv//swe)
NATURAL SCIENCES  -- Biological Sciences (hsv//eng)
MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Kardiologi (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- Cardiac and Cardiovascular Systems (hsv//eng)

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ref (subject category)
art (subject category)

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Evangelou, Evang ...
Warren, Helen R
Mosen-Ansorena, ...
Mifsud, Borbala
Pazoki, Raha
Gao, He
show more...
Ntritsos, Georgi ...
Dimou, Niki
Cabrera, Claudia ...
Karaman, Ibrahim
Ng, Fu Liang
Evangelou, Marin ...
Witkowska, Katar ...
Tzanis, Evan
Hellwege, Jackly ...
Giri, Ayush
Velez Edwards, D ...
Sun, Yan V
Cho, Kelly
Gaziano, J Micha ...
Wilson, Peter W ...
Tsao, Philip S
Kovesdy, Csaba P
Esko, Tonu
Mägi, Reedik
Milani, Lili
Almgren, Peter
Boutin, Thibaud
Debette, Stéphan ...
Ding, Jun
Giulianini, Fran ...
Holliday, Elizab ...
Jackson, Anne U
Li-Gao, Ruifang
Lin, Wei-Yu
Luan, Jian'an
Mangino, Massimo
Oldmeadow, Chris ...
Prins, Bram Pete ...
Qian, Yong
Sargurupremraj, ...
Shah, Nabi
Surendran, Prave ...
Thériault, Sébas ...
Verweij, Niek
Willems, Sara M
Zhao, Jing-Hua
Amouyel, Philipp ...
Connell, John
de Mutsert, René ...
Doney, Alex S F
Farrall, Martin
Menni, Cristina
Morris, Andrew D
Noordam, Raymond
Paré, Guillaume
Poulter, Neil R
Shields, Denis C
Stanton, Alice
Thom, Simon
Abecasis, Gonçal ...
Amin, Najaf
Arking, Dan E
Lind, Lars
Barbieri, Cateri ...
Batini, Chiara
Bis, Joshua C
Blake, Tineka
Bochud, Murielle
Boehnke, Michael
Boerwinkle, Eric
Boomsma, Dorret ...
Bottinger, Erwin ...
Braund, Peter S
Brumat, Marco
Campbell, Archie
Campbell, Harry
Chakravarti, Ara ...
Chambers, John C
Chauhan, Ganesh
Ciullo, Marina
Cocca, Massimili ...
Collins, Francis
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Davies, Gail
de Borst, Martin ...
de Geus, Eco J
Deary, Ian J
Deelen, Joris
Del Greco M, Fab ...
Demirkale, Cumhu ...
Dörr, Marcus
Ehret, Georg B
Elosua, Roberto
Enroth, Stefan, ...
Erzurumluoglu, A ...
Ferreira, Teresa
Frånberg, Mattia ...
Franco, Oscar H
Gandin, Ilaria
Gasparini, Paolo
Giedraitis, Vilm ...
Gieger, Christia ...
Girotto, Giorgia
Goel, Anuj
Gow, Alan J
Gudnason, Vilmun ...
Guo, Xiuqing
Gyllensten, Ulf ...
Hamsten, Anders
Harris, Tamara B
Harris, Sarah E
Hartman, Cathari ...
Havulinna, Aki S
Hicks, Andrew A
Hofer, Edith
Hofman, Albert
Hottenga, Jouke- ...
Huffman, Jennife ...
Hwang, Shih-Jen
Ingelsson, Erik, ...
James, Alan
Jansen, Rick
Jarvelin, Marjo- ...
Joehanes, Roby
Johansson, Åsa
Johnson, Andrew ...
Joshi, Peter K
Jousilahti, Pekk ...
Jukema, J Wouter
Jula, Antti
Kähönen, Mika
Kathiresan, Seka ...
Keavney, Bernard ...
Khaw, Kay-Tee
Knekt, Paul
Knight, Joanne
Kolcic, Ivana
Kooner, Jaspal S
Koskinen, Seppo
Kristiansson, Ka ...
Kutalik, Zoltan
Laan, Maris
Larson, Marty
Launer, Lenore J
Lehne, Benjamin
Lehtimäki, Terho
Liewald, David C ...
Lin, Li
Lindgren, Cecili ...
Liu, YongMei
Loos, Ruth J F
Lopez, Lorna M
Lu, Yingchang
Lyytikäinen, Leo ...
Mahajan, Anubha
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Marrugat, Jaume
Marten, Jonathan
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Ridker, Paul M
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Riese, Harriëtte
Ripatti, Samuli
Robino, Antoniet ...
Rose, Lynda M
Rotter, Jerome I
Rudan, Igor
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Saba, Yasaman
Sala, Cinzia F
Salomaa, Veikko
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Schmidt, Reinhol ...
Schmidt, Helena
Shrine, Nick
Siscovick, David
Smith, Albert V
Snieder, Harold
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Sorice, Rossella
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Stott, David J
Strachan, David ...
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Taylor, Kent D
Teumer, Alexande ...
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Vaez, Ahmad
van der Most, Pe ...
van Duijn, Corne ...
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Verwoert, Germai ...
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Völker, Uwe
Vollenweider, Pe ...
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Watkins, Hugh
Wild, Sarah H
Willemsen, Gonne ...
Wilson, James F
Wright, Alan F
Yao, Jie
Zemunik, Tatijan ...
Zhang, Weihua
Attia, John R
Butterworth, Ada ...
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Conen, David
Cucca, Francesco
Danesh, John
Hayward, Carolin ...
Howson, Joanna M ...
Laakso, Markku
Lakatta, Edward ...
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Melander, Olle
Mook-Kanamori, D ...
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Risch, Lorenz
Scott, Robert A
Scott, Rodney J
Sever, Peter
Spector, Tim D
van der Harst, P ...
Wareham, Nichola ...
Zeggini, Elefthe ...
Levy, Daniel
Munroe, Patricia ...
Newton-Cheh, Chr ...
Brown, Morris J
Metspalu, Andres
Hung, Adriana M
O'Donnell, Chris ...
Edwards, Todd L
Psaty, Bruce M
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show less...
About the subject
MEDICAL AND HEALTH SCIENCES
MEDICAL AND HEAL ...
and Basic Medicine
and Medical Genetics
NATURAL SCIENCES
NATURAL SCIENCES
and Biological Scien ...
MEDICAL AND HEALTH SCIENCES
MEDICAL AND HEAL ...
and Clinical Medicin ...
and Cardiac and Card ...
Articles in the publication
Nature Genetics
By the university
Uppsala University
Stockholm University
Karolinska Institutet
Lund University

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