| 1. |
- Chan, Sherwin, et al.
(författare)
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Regulation of PfEMP1-VAR2CSA translation by a Plasmodium translation-enhancing factor
- 2017
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Ingår i: Nature Microbiology. - : Springer Science and Business Media LLC. - 2058-5276. ; 2:7
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Tidskriftsartikel (refereegranskat)abstract
- Pregnancy-associated malaria commonly involves the binding of Plasmodium falciparum-infected erythrocytes to placental chondroitin sulfate A (CSA) through the PfEMP1-VAR2CSA protein. VAR2CSA is translationally repressed by an upstream open reading frame. In this study, we report that the P. falciparum translation enhancing factor (PTEF) relieves upstream open reading frame repression and thereby facilitates VAR2CSA translation. VAR2CSA protein levels in var2csa-transcribing parasites are dependent on the expression level of PTEF, and the alleviation of upstream open reading frame repression requires the proteolytic processing of PTEF by PfCalpain. Cleavage generates a C-terminal domain that contains a sterile-alpha-motif-like domain. The C-terminal domain is permissive to cytoplasmic shuttling and interacts with ribosomes to facilitate translational derepression of the var2csa coding sequence. It also enhances translation in a heterologous translation system and thus represents the first non-canonical translation enhancing factor to be found in a protozoan. Our results implicate PTEF in regulating placental CSA binding of infected erythrocytes.
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| 2. |
- Pericault, Youen, 1992-, et al.
(författare)
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A novel freeze protection strategy for shallow buried sewer pipes : temperature modelling and field investigation
- 2017
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Ingår i: Water Science and Technology. - : IWA Publishing. - 0273-1223 .- 1996-9732. ; 76:2, s. 294-301
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Tidskriftsartikel (refereegranskat)abstract
- The burial of sewer and water pipes below the maximum ground frost depth can be very costly and laborious in regions with cold winters. If a freeze protection measure is applied, the utility lines can be installed in a shallower trench to reduce the excavation needs. One freeze protection measure, so called heat tracing, consists in supplying heat along the pipes. In this work, the use of 4th generation district heating as a heat tracing solution was investigated at a pilot site in Kiruna, Sweden. The influence of the system on sewer and water pipe temperatures was studied at a snow-free and snow-covered cross section. To this end, five heat tracing temperatures were tested and the corresponding sewer and water pipe temperatures were measured. The field experiment was also simulated with a two dimensional finite volume model. The study showed that, under the climatic conditions of the experiment, a heat tracing temperature of 25 °C allowed to prevent freezing of the pipes while keeping drinking water pipes in a safe temperature range at both cross sections. The other main result was that the developed finite volume model of the sections showed a good fitting to the experimental data
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| 3. |
- Vesterlund, Mattias, et al.
(författare)
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Design optimization of a district heating network expansion : a case study for the town of Kiruna
- 2017
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Ingår i: Applied Sciences. - Basel : MDPI. - 2076-3417. ; 7:5
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Tidskriftsartikel (refereegranskat)abstract
- The urbanization of new areas beyond the existing perimeter of a town implies the expansion of several infrastructures, including the district heating network. The main variables involved in the design of the district heating network expansion are the layout of the new pipes, their diameters, and the capacity of the new heat production sites that are required to satisfy the increased demand of room heating and hot tap water. In this paper, a multi-objective evolutionary algorithm is applied to the minimization of the costs related to the expansion of the district heating network of the town of Kiruna, in northern Sweden. The results show that the spectrum of the optimal design compromises between investment costs for the new pipes and the new heat generation site on one side, and operating costs due to overall fuel consumption and pumping power in the network on the other. The presented methodology is a tool meant for the decision makers in the company who own the district heating network, to evaluate all the possible best design alternatives before making a decision.
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| 4. |
- Vesterlund, Mattias, 1980-
(författare)
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District heating system analysis and challenges within the urban transformation of Kiruna
- 2017
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Doktorsavhandling (övrigt vetenskapligt/konstnärligt)abstract
- There is currently an ongoing urban transformation in a small Swedish town named Kiruna, it is located in the very north of Sweden well above the Arctic Circle in a sub-arctic climate. Large part of the town will be relocated due to the ground deformation that is caused by the progressing iron ore mining activity and it is affecting all infrastructures of the town. This thesis aims to accomplish a holistic analysis on the district heating (DH) system for the town of Kiruna and its future challenges.Energy companies with a DH system recognize the importance in having a good understanding about the network characteristics, for obtaining an efficient and stabile heat delivery to the end-users. In this thesis, a method for modeling and simulation of meshed DH networks is described, that makes it possible to study and analyze the flow pattern in order to locate non-obvious paths, bottlenecks and overloaded pipes.For carrying out the DH simulations a fundamental input is to set the thermal losses for each pipe segment in the model, a fictitious series with all pipe diameters is created which corresponds to the annual losses in the real network. In comparison with the pipes series manufactured today the created one is best described by the series with least insulation and highest thermal losses. The studied network has its origin in the 60th and is the sum of the different piping technics that has been valid over time, this mixture is positioning the thermal performance as a close to a worst-case scenario.To the meshed DH network a number of heat production sites are connected for delivering the thermal requested by the end-users, each site consisting of several boilers and using different resources. A hybrid evolutionary-Mixed Integer Linear Programing (MILP) optimization approach is developed and applied for finding the cost-optimal heat production for three scenarios in combination of two heating demand levels. It is stated that no matter the geographically location of the site the cheapest resource should always be favorable as fuel, in the case when the same resource is viable at different sites a differentiated heat production is obtained. The supply temperature from each site is found to be the one lowest possible in order to serve all site-concerned end-users with a temperature level high enough for hot water production. The findings recommend a network temperatures reduction with the consequence in higher cost related to pumping work, but is lower than the savings due to the reduction in thermal losses.In order to provide the relocated part of the town with DH the hybrid evolutionary-MILP optimization routine is reshaped for finding different alternatives for network expansion layouts. The result is presented as a multi objective analysis between the operation cost and installation cost, showing the complete spectra of all optimal possible solutions and how the different cost correlate to each other. In this way, the outcome can be used for support in decision making, helping network owners is their planning and pipe sizing for new areas.For constructing the buildings that will populate the new city-area the Swedish government has stated a number of recommendations for achieving livable thermal indoor climate. An investigation is carried out analyzing the impact from the usage of three different heating system; air/air heat pump, air heating and floor heating in a low energy family house, where the first two system are aimed to use heat from the DH network. The analysis show that only the floor heating system satisfies the recommendations stated, but with carefully planning an air heating system could also fulfill the recommendations. Further, a techno-economical evaluation declares that the cheapest heating cost over 30 years is by using an air/air heat pump. In order to make DH competitive as heating source the needed price reduction is found for the hydronic floor and air heating system.Finally, three different building energy performance scenarios are studied in conjunction with the urban transformation in combination with the suggested energy measures from the Energy Performance certificates (EPC). In order to reach the national target entailing a reduction of 50% until 2050 all re-built buildings have to be built with passive standard and all advised measures in the EPC has to be carried out. Wort noticing is that the scenarios is analyzed as part of a 3-D City Model, which is found to be a worthwhile working tool for staff dealing with energy related issues.
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| 5. |
- Vesterlund, Mattias, et al.
(författare)
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Optimization of multi-source complex district heating network, a case study
- 2017
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Ingår i: Energy. - : Elsevier. - 0360-5442 .- 1873-6785. ; 126, s. 53-63
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Tidskriftsartikel (refereegranskat)abstract
- The level of complexity for a district heating network increases with the maturity of the network, and this affects the pattern of the distribution of the hot water from the heat production sites to the end users. The majority of district heating systems are also multi-source networks, typically supported with heat from one main production site and other smaller satellite sites that are activated when required. In general, local energy companies have a lack of knowledge regarding how a meshed network behaves when different production sites are operated. The schedule of heat generation at the different sites is often based on staff experience and some general rules of thumb.In this paper a method for modeling and simulating complex district networks is further developed in order to optimize the total operating costs of a multi-source network, with constraints on the pressure and temperature levels in the user areas and on the heat generation characteristics at each production site.The optimization results show that the usage of the cheapest resources is preferred to a distributed generation of heat, even if some of the pipes may exceed the recommended thermal load capacity. The main site water supply temperature is found to be the lowest allowed by the constraint on the temperature of the water supplied to the end users, since the decrease of the costs associated with the lower thermal losses in the network is not counterbalanced by the increase of those associated with the pumping power of a larger water mass flow rate.
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